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Cited by 522Protein Kinase Regulation and GTPase SignalingCellular transport and secretionPI3K/AKT/mTOR signaling in cancer

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

Martin, T. F. J.·1998·Annual Review of Cell and Developmental Biology
DOI 10.1146/annurev.cellbio.14.1.231
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Abstract

Signaling roles for phosphoinositides that involve their regulated hydrolysis to generate second messengers have been well characterized. Recent work has revealed additional signaling roles for phosphoinositides that do not involve their hydrolysis. PtdIns 3-P, PtdIns 3,4,5-P3, and PtdIns 4,5-P2 function as site-specific signals on membranes that recruit and/or activate proteins for the assembly of spatially localized functional complexes. A large number of phosphoinositide-binding proteins have been identified as the potential effectors for phosphoinositide signals. Common themes of localized signal generation and the spatially localized recruitment of effector proteins appear to underlie mechanisms employed in signal transduction, cytoskeletal, and membrane trafficking events.

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Crossref · 10.1146/annurev.cellbio.14.1.231

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  • 4,5-PIP2 is thought to govern the distribution and function of cytoskeletal and signaling proteins bearing pleckstrin homology domains or lysine/arginine-rich hydrophobic motifs that interact directly and specifically with its headgroup.

    “This phospholipid is thought to govern the distribution and function of a variety of cytoskeletal and signaling proteins that bear pleckstrin homology (PH) domains or lysine/arginine-rich hydrophobic motifs, which interact directly and specifically with the headgroup of 4,5-PIP2 (Bottomley et al. 1998; Hinchliffe et al. 1998; Martin 1998; Czech 2000).”

    From Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis (2000) · cites this paper as Martin 1998

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Authors
Martin, T. F. J.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Martin, T. F. J.
ORCID
Martin, T. F. J.
Venue
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Published
1998-11
Volume
14
Issue
1
Pages
231-264
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
DOI
10.1146/annurev.cellbio.14.1.231
OpenAlex
W2120077272
Cited by
522
References
2
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 13 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 16
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
phosphoinositides, phosphoinositide signaling, PtdIns(3)P, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphoinositide-binding proteins, signal transduction, cytoskeleton regulation, membrane trafficking
MeSH terms
Animals, Cell Membrane, Cytoskeleton, Humans, Membrane Fusion, Membrane Proteins, Phosphatidylinositols, Phosphorylation, Protein Kinases, Signal Transduction

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