AMPA-receptor activation regulates the diffusion of a membrane marker in parallel with dendritic spine motility in the mouse hippocampus
Abstract
Dendritic spines are the site of most excitatory connections in the hippocampus. We have investigated the diffusibility of a membrane-bound green fluorescent protein (mGFP) within the inner leaflet of the plasma membrane using Fluorescence Recovery After Photobleaching. In dendritic spines the diffusion of mGFP was significantly retarded relative to the dendritic shaft. In parallel, we have assessed the motility of dendritic spines, and found an inverse correlation between spine motility and the rate of diffusion of mGFP. We then tested the influence of glutamate receptor activation or blockade, and the involvement of the actin cytoskeleton (using latrunculin A) on spine motility and mGFP diffusion. These results show that glutamate receptors regulate the mobility of molecules in the inner leaflet of the plasma membrane through an action upon the actin cytoskeleton, suggesting a novel mechanism for the regulation of postsynaptic receptor density and composition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Live-cell imaging techniques like FRAP and single molecule tracking changed the view that glutamate receptors are restricted to synapses.
“Whereas reports based on static EM suggested that glutamate receptors are restricted to synapses (Nusser, 2000), live-cell imaging techniques like FRAP and single molecule tracking changed this view radically (Richards et al., 2004; Triller and Choquet, 2005).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Richards et al., 2004
Mushroom-shaped spines form a membrane compartment in which diffusion is slowed.
“indicating that mushroom-shaped spines form a membrane compartment in which diffusion is slowed.”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Richards et al., 2004
Fluorescently-tagged plasma membrane probes in spines showed a faster recovery rate in stubby than in mushroom-shaped spines.
“Furthermore, fluorescently-tagged plasma membrane probes in spines of different morphologies showed a faster recovery rate in stubby than in mushroom-shaped spines (Richards et al., 2004; Ashby et al., 2006), indicating that mushroom-shaped spines form a membrane compartment in which diffusion is slowed.”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Richards et al., 2004
Cites
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Pollard, T. D., & Borisy, G. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00120-x · Cited by 4,203 · see citing works
Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains
Ritter, M., Schmidt, S., Jakab, M., Paulmichl, M., & Henderson, R. M. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350122 · Cited by 3,923 · see citing works
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics
Axelrod, D., Koppel, D. E., Schlessinger, J., Elson, E. L., & Webb, W. W. (1976) · Biophysical Journal · doi:10.1016/s0006-3495(76)85755-4 · Cited by 2,717 · see citing works
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Trachtenberg, J. T., Chen, B. E., Knott, G. W., Feng, G., Sanes, J. R., Welker, E., & Svoboda, K. (2002) · Nature · doi:10.1038/nature01273 · Cited by 1,927 · see citing works
SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics
Saxton, M. J., & Jacobson, K. (1997) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.26.1.373 · Cited by 1,810 · see citing works
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,664 · see citing works
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletić‐Savatić, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,189 · see citing works
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
Loisel, T. P., Boujemaa‐Paterski, R., Pantaloni, D., & Carlier, M. (1999) · Nature · doi:10.1038/44183 · Cited by 970 · see citing works
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Organotypic slice cultures: a technique has come of age
Gähwiler, B. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01122-3 · Cited by 884 · see citing works
Self-citationActin-based plasticity in dendritic spines
Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815 · see citing works
Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo
Lendvai, B., Stern, E. A., Chen, B., & Svoboda, K. (2000) · Nature · doi:10.1038/35009107 · Cited by 802 · see citing works
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works
Laux, T., Fukami, K., Thelen, M., Golub, T., Frey, D., & Caroni, P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.7.1455 · Cited by 617 · see citing works
Self-citationMartin, T. F. J. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.231 · Cited by 522 · see citing works
Cell control by membrane–cytoskeleton adhesion
Sheetz, M. P. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073095 · Cited by 478 · see citing works
Constrained diffusion or immobile fraction on cell surfaces: a new interpretation
Feder, T., Brust‐Mascher, I., Slattery, J. P., Baird, B. A., & Webb, W. W. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79846-6 · Cited by 476 · see citing works
Direct measurement of coupling between dendritic spines and shafts
Svoboda, K., Tank, D. W., & Denk, W. (1996) · Science · doi:10.1126/science.272.5262.716 · Cited by 472 · see citing works
Membrane Tether Formation from Blebbing Cells
Dai, J., & Sheetz, M. P. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77168-7 · Cited by 447 · see citing works
Glutamate receptors regulate actin-based plasticity in dendritic spines
Fischer, M., Kaech, S., Wagner, U., Brinkhaus, H., & Matus, A. (2000) · Nature Neuroscience · doi:10.1038/78791 · Cited by 446 · see citing works
Mobile NMDA Receptors at Hippocampal Synapses
Tovar, K. R., & Westbrook, G. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00658-x · Cited by 428 · see citing works
Developmental regulation of spine motility in the mammalian central nervous system
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13438 · Cited by 412 · see citing works
The role of receptor diffusion in the organization of the postsynaptic membrane
Choquet, D., & Triller, A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1077 · Cited by 410 · see citing works
A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation
Kim, C.-H., & Lisman, J. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04314.1999 · Cited by 386 · see citing works
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374 · see citing works
Overexpression of growth-associated proteins in the neurons of adult transgenic mice
Caroni, P. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(96)00121-5 · Cited by 358 · see citing works
Self-citationLin, C.-H., Yeh, S.-H., Lin, C.-H., Lu, K., Leu, T., Chang, W., & Gean, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00433-0 · Cited by 342 · see citing works
Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex
Shepherd, G. M. G., Pologruto, T. A., & Svoboda, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00152-1 · Cited by 322 · see citing works
Actin cytoskeleton regulation through modulation of PI(4,5)P2 rafts
Caroni, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4332 · Cited by 307 · see citing works
Self-citationTakenawa, T., & Itoh, T. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(01)00165-2 · Cited by 277 · see citing works
Sanna, P. P., Cammalleri, M., Berton, F., Simpson, C., Lütjens, R., Bloom, F. E., & Francesconi, W. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03359.2002 · Cited by 250 · see citing works
AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks
Paola, V. D., Arber, S., & Caroni, P. (2003) · Nature Neuroscience · doi:10.1038/nn1046 · Cited by 235 · see citing works
Self-citationRegulation of Spine Calcium Dynamics by Rapid Spine Motility
Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 201 · see citing works
Actin and the agile spine: How and why do dendritic spines dance?
Halpain, S. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01576-9 · Cited by 169 · see citing works
Akaaboune, M., Grady, R. M., Turney, S., Sanes, J. R., & Lichtman, J. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00739-0 · Cited by 97 · see citing works
Hill, K. M., Welti, S., Yu, J., Murray, J. T., Yip, S.-C., Condeelis, J. S., Segall, J. E., & Backer, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3741 · Cited by 79 · see citing works
Schafer, D. A. (2003) · Nature Cell Biology · doi:10.1038/ncb0803-693 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works
Dendritic spines and long-term plasticity
Segal, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1649 · Cited by 489 · see citing works
Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses
Haber, M., Zhou, L., & Murai, K. K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1302-06.2006 · Cited by 413 · see citing works
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356 · see citing works
Ashby, M. C., Maier, S. R., Nishimune, A., & Henley, J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1235-06.2006 · Cited by 302 · see citing works
Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works
Frost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 263 · see citing works
New Concepts in Synaptic Biology Derived from Single-Molecule Imaging
Triller, A., & Choquet, D. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.022 · Cited by 262 · see citing works
Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology
Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187 · see citing works
Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons
Vlachos, A., Korkotian, E., Schoenfeld, E., Copanaki, E., Deller, T., & Segal, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5528-08.2009 · Cited by 181 · see citing works
Local Sharing as a Predominant Determinant of Synaptic Matrix Molecular Dynamics
Tsuriel, S., Geva, R., Zamorano, P. L., Dresbach, T., Boeckers, T. M., Gundelfinger, E. D., Garner, C. C., & Ziv, N. E. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040271 · Cited by 164 · see citing works
Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures
Richards, D. A., Mateos, J. M., Hugel, S., de Paola, V., Caroni, P., Gähwiler, B. H., & McKinney, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501881102 · Cited by 161 · see citing works
Self-citationCalcium regulation of actin dynamics in dendritic spines
Oertner, T. G., & Matus, A. I. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.016 · Cited by 159 · see citing works
AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse
Groc, L., & Choquet, D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0254-9 · Cited by 158 · see citing works
AMPA receptors as drug targets in neurological disease—advantages, caveats, and future outlook
Chang, P. K. ‐., Verbich, D., & McKinney, R. A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08165.x · Cited by 155 · see citing works
Self-citationCytoskeleton Regulation of Glycine Receptor Number at Synapses and Diffusion in the Plasma Membrane
Charrier, C., Ehrensperger, M.-V., Dahan, M., Lévi, S., & Triller, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1758-06.2006 · Cited by 137 · see citing works
Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
McKinney, R. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178905 · Cited by 133 · see citing works
Self-citationCadherin activity is required for activity-induced spine remodeling
Okamura, K., Tanaka, H., Yagita, Y., Saeki, Y., Taguchi, A., Hiraoka, Y., Zeng, L., Colman, D., & Miki, N. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406030 · Cited by 132 · see citing works
Growth of dendritic spines: a continuing story
Matus, A. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.015 · Cited by 123 · see citing works
Activity-Dependent Movements of Postsynaptic Scaffolds at Inhibitory Synapses
Hanus, C., Ehrensperger, M.-V., & Triller, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5123-05.2006 · Cited by 98 · see citing works
The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity
Segal, M., Vlachos, A., & Korkotian, E. (2010) · The Neuroscientist · doi:10.1177/1073858409355829 · Cited by 91 · see citing works
Dynamin-dependent Membrane Drift Recruits AMPA Receptors to Dendritic Spines
Jaskolski, F., Mayo-Martin, M. B., Jane, D. E., & Henley, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808401200 · Cited by 65 · see citing works
Barriers in the brain: resolving dendritic spine morphology and compartmentalization
Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62 · see citing works
“Whereas reports based on static EM suggested that glutamate receptors are restricted to synapses (Nusser, 2000), live-cell imaging techniques like FRAP and single molecule tracking changed this view radically (Richards et al., 2004; Triller and Choquet, 2005).”
Kusters, R., Kapitein, L. C., Hoogenraad, C. C., & Storm, C. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.11.016 · Cited by 53 · see citing works
Probing the Dynamics of Protein–Protein Interactions at Neuronal Contacts by Optical Imaging
Thoumine, O. R., Ewers, H., Heine, M., Groc, L., Frischknecht, R., Giannone, G., Poujol, C., Legros, P., Lounis, B., Cognet, L., et al. (2008) · Chemical Reviews · doi:10.1021/cr078204m · Cited by 58 · see citing works
Effects of N-cadherin disruption on spine morphological dynamics
Mysore, S. P. (2007) · Frontiers in Cellular Neuroscience · doi:10.3389/neuro.03.001.2007 · Cited by 50 · see citing works
Prithviraj, R., Kelly, K. M., Espinoza‐Lewis, R. A., Hexom, T., Clark, A. B., & Inglis, F. M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20590 · Cited by 45 · see citing works
Synaptic receptor trafficking: The lateral point of view
Jaskolski, F., & Henley, J. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.075 · Cited by 41 · see citing works
Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins
Yamashita, T., Hakizimana, P., Wu, S., Hassan, A. M., Jacob, S., Temirov, J. P., Fang, J., Mellado-Lagarde, M., Gursky, R. P., HORNER, L. H., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005500 · Cited by 36 · see citing works
Smith, B. A., Roy, H., Koninck, P. D., Grütter, P., & Koninck, Y. D. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.092361 · Cited by 32 · see citing works
Imoukhuede, P. I., Moss, F. J., Michael, D. J., Chow, R. H., & Lester, H. A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.070 · Cited by 29 · see citing works
Physiological roles of spine motility: development, plasticity and disorders
McKinney, R. A. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051299 · Cited by 29 · see citing works
Self-citationHugel, S., Abegg, M. H., Paola, V. D., Caroni, P., Gähwiler, B. H., & McKinney, R. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn118 · Cited by 25 · see citing works
Self-citationSpine Modifications Associated with Long-Term Potentiation
Yang, Y., & Zhou, Q. (2009) · The Neuroscientist · doi:10.1177/1073858409340800 · Cited by 25 · see citing works
Zhou, C., Wang, Y., Pan, D., Sun, Y., & Cao, J. (2016) · Food Research International · doi:10.1016/j.foodres.2016.10.032 · Cited by 21 · see citing works
Glial Cell Modulation of Dendritic Spine Structure and Synaptic Function
Rasia‐Filho, A. A., Calcagnotto, M. E., & Halbach, O. V. B. U. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_6 · Cited by 21 · see citing works
Marlar, S., Arnspang, E. C., Pedersen, G. A., Koffman, J. S., & Nejsum, L. N. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.06.005 · Cited by 15 · see citing works
Spine Remodeling and Synaptic Modification
Wang, X., & Zhou, Q. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8093-9 · Cited by 15 · see citing works
Cytoskeletal mechanisms for synaptic potentiation
Schwechter, B., & Tolias, K. F. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.27343 · Cited by 11 · see citing works
Laser‐Mediated Microlesions in Mouse Neocortex to Investigate Neuronal Degeneration and Regeneration
Jackson, J., Canty, A. J., Huang, L., & Paola, V. D. (2015) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0224s73 · Cited by 9 · see citing works
MARCKS for Maintenance in Dendritic Spines
Matus, A. I. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.013 · Cited by 8 · see citing works
Activity maintains structural plasticity of mossy fiber terminals in the hippocampus
Chierzi, S., Stachniak, T. J., Trudel, E., Bourque, C. W., & Murai, K. K. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.05.004 · Cited by 8 · see citing works
Dynamic Stabilization: Structural Plasticity at Inhibitory Postsynaptic Sites
Kneussel, M. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00501.x · Cited by 5 · see citing works
Synaptic Dialogue: Substrate for Protein-Synthesis-Independent Long-Term Memory
Holahan, M. R., & Routtenberg, A. (2006) · Springer eBooks · doi:10.1007/0-387-25443-9_24 · Cited by 2 · see citing works
Dendritic Organelles for Postsynaptic Trafficking
Hanus, C., & Ehlers, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_8 · Cited by 1 · see citing works
So, why do they dance, after all?
Segal, M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.069260 · Cited by 1 · see citing works
Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses
Choquet, D., & Triller, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_13
The actin-binding protein profilin II in neuronal plasticity
Birbach, A. (2006) · edoc (University of Basel) · doi:10.5451/unibas-003950065
Profilin isoforms in the hippocampus in health and disease
Zessin, S. (2014) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-201501221125-0
- Authors
- Richards, D. A., De Paola, V., Caroni, P., Gähwiler, B. H., & McKinney, R. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Friedrich Miescher Institute (CH)
- University of Zurich (CH)
- Corresponding author
- Richards, D. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 558
- Issue
- 2
- Pages
- 503-512
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2117914181
- Cited by
- 49
- References
- 39
- Citations by year
- 2023: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AMPA receptors, membrane diffusion, hippocampus, glutamate receptor activation, actin cytoskeleton, latrunculin A
- MeSH terms
- Actins, Animals, Cell Membrane, Diffusion, Hippocampus, Mice, Transgenic, Organ Culture Techniques, Receptors, AMPA, Fluorescence Recovery After Photobleaching, Dendritic Spines, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review