The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transport Between the Cell Nucleus and the Cytoplasm
Abstract
▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and ribosomes are made in the nucleus and need to be exported to the cytoplasm. Nuclear import and export proceed through nuclear pore complexes and can occur along a great number of distinct pathways, many of which are mediated by importin β-related nuclear transport receptors. These receptors shuttle between nucleus and cytoplasm, and they bind transport substrates either directly or via adapter molecules. They all cooperate with the RanGTPase system to regulate the interactions with their cargoes. Another focus of our review is nuclear export of messenger RNA, which apparently largely relies on export mediators distinct from importin β-related factors. We discuss mechanistic aspects and the energetics of transport receptor function and describe a number of pathways in detail.
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Cites
Distinct functions for the two importin subunits in nuclear protein import
Görlich, D., Vogel, F., Mills, A. D., Hartmann, E., & Laskey, R. A. (1995) · Nature · doi:10.1038/377246a0 · Cited by 474
Self-citationFagotto, F., Glück, U., & Gumbiner, B. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70082-x · Cited by 434
Pasquinelli, A. E., Ernst, R. K., Lund, E., Grimm, C., Zapp, M. L., Rekosh, D., Hammarskjöld, M., & Dahlberg, J. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7500 · Cited by 239
Cited by
Molecular mechanism of the nuclear protein import cycle
Stewart, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2114 · Cited by 919
Androgen Receptor (AR) Coregulators: An Overview
Heinlein, C. A., & Chang, C. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0460 · Cited by 943
Ubiquitination regulates PTEN nuclear import and tumor suppression
Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N. P., Carver, B. S., Cordon-Cardo, C., Erdjument-Bromage, H., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.040 · Cited by 748
OpenCell: Endogenous tagging for the cartography of human cellular organization
Cho, N. H., Cheveralls, K. C., Brunner, A.-D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., et al. (2022) · Science · doi:10.1126/science.abi6983 · Cited by 567
“Many proteins were found in both nucleus and cytoplasm (21% of our library), highlighting the importance of the nucleocytoplasmic import and export machinery in shaping global cellular function ( 46 , 47 ).”
BackgroundA Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore Complexes
Frey, S., & Görlich, D. (2007) · Cell · doi:10.1016/j.cell.2007.06.024 · Cited by 567
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Metadata
- Authors
- Görlich, D., & Kutay, U.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1999-11
- Volume
- 15
- Issue
- 1
- Pages
- 607-660
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2165306451
- Cited by
- 2,022
- References
- 3
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
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