The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.
Dynamin and Its Role in Membrane Fission
Open accessAbstract
▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and possibly vesicle trafficking in and out of the Golgi. In addition to the GTPase domain, dynamin also contains a pleckstrin homology domain (PH) implicated in membrane binding, a GTPase effector domain (GED) shown to be essential for self-assembly and stimulated GTPase activity, and a C-terminal proline-rich domain (PRD), which contains several SH3-binding sites. Dynamin partners bind to the PRD and may either stimulate dynamin's GTPase activity or target dynamin to the plasma membrane. Purified dynamin readily self-assembles into rings or spirals. This striking structural property supports the hypothesis that dynamin wraps around the necks of budding vesicles where it plays a key role in membrane fission. The focus of this review is on the relationship between the GTPase and self-assembly properties of dynamin and its cellular function.
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Cites
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PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences
Zhang, F. L., & Casey, P. J. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.001325 · Cited by 1,743
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.
Damke, H., Baba, T., Warnock, D. E., & Schmid, S. L. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.4.915 · Cited by 1,204
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Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
Hinshaw, J. E., & Schmid, S. L. (1995) · Nature · doi:10.1038/374190a0 · Cited by 823
Self-citationThe dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
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Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic
van der Bliek, A. M., & Meyerowrtz, E. M. (1991) · Nature · doi:10.1038/351411a0 · Cited by 769
Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals
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Dynamin-mediated Internalization of Caveolae
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A Human Dynamin-related Protein Controls the Distribution of Mitochondria
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Cited by
The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755
Maxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,729
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., & Mihara, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607279200 · Cited by 1,226
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
Lee, Y.-J., Jeong, S.-Y., Karbowski, M., Smith, C. L., & Youle, R. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0294 · Cited by 1,042
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 940
Metadata
- Authors
- Hinshaw, J. E.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2000-11
- Volume
- 16
- Issue
- 1
- Pages
- 483-519
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2157920366
- Cited by
- 699
- References
- 208
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
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