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Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis
Abstract
Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.
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The model suggests a role for Dab2 in mediating the endocytosis of signaling complexes and regulating signaling at the endosomes.
“The model suggests a role for Dab2 in mediating the endocytosis of signaling complexes and regulating signaling at the endosomes”
From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Vieira et al., 1996
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Research works printed but not linked: 19
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Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice
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Metadata
- Authors
- Vieira, A. V., Lamaze, C., & Schmid, S. L.
- Affiliations
- Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2086-2089
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 883
- References
- 0
- Language
- en
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