The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Structural Basis for the Interaction of Tubulin with Proteins and Drugs that Affect Microtubule Dynamics
Abstract
▪ Abstract The microtubule cytoskeleton is a highly regulated system. At different times in the cell cycle and positions within the organism, microtubules can be very stable or highly dynamic. Stability and dynamics are regulated by interaction with a large number of proteins that themselves may change at specific points in the cell cycle. Exogenous ligands can disrupt the normal processes by either increasing or decreasing microtubule stability and inhibiting their dynamic behavior. The recent determination of the structure of tubulin, the main component of microtubules, makes it possible now to begin to understand the details of these interactions. We review here the structure of the tubulin dimer, with particular regard to how proteins and drugs may bind and modulate microtubule dynamics.
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Citations
Cites
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Self-citationHigh-Resolution Model of the Microtubule
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Cited by
Microtubules and resistance to tubulin-binding agents
Kavallaris, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2803 · Cited by 1,120
Mechanisms of Taxol resistance related to microtubules
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The effects of mechanical forces on intestinal physiology and pathology
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G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
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Acetylated microtubules are required for fusion of autophagosomes with lysosomes
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Metadata
- Authors
- Downing, K. H.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2000-11
- Volume
- 16
- Issue
- 1
- Pages
- 89-111
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2165629556
- Cited by
- 382
- References
- 65
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Downing, K. H. (2000). Structural Basis for the Interaction of Tubulin with Proteins and Drugs that Affect Microtubule Dynamics. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.16.1.89
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
