The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Left-Right Asymmetry Determination in Vertebrates
Abstract
▪ Abstract A distinctive and essential feature of the vertebrate body is a pronounced left-right asymmetry of internal organs and the central nervous system. Remarkably, the direction of left-right asymmetry is consistent among all normal individuals in a species and, for many organs, is also conserved across species, despite the normal health of individuals with mirror-image anatomy. The mechanisms that determine stereotypic left-right asymmetry have fascinated biologists for over a century. Only recently, however, has our understanding of the left-right patterning been pushed forward by links to specific genes and proteins. Here we examine the molecular biology of the three principal steps in left-right determination: breaking bilateral symmetry, propagation and reinforcement of pattern, and the translation of pattern into asymmetric organ morphogenesis.
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Cites
Metzler, M., Gertz, A., Sarkar, M., Schachter, H., Schrader, J. W., & Marth, J. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06480.x · Cited by 339
Cited by
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Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination
Okada, Y., Takeda, S., Tanaka, Y., Belmonte, J.-C. I., & Hirokawa, N. (2005) · Cell · doi:10.1016/j.cell.2005.04.008 · Cited by 489
The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice
Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A., Skryabin, B., Horst, J., Blum, M., & Dworniczak, B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00869-2 · Cited by 425
Levin, M., Thorlin, T., Robinson, K. R., Nogi, T., & Mercola, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00939-x · Cited by 403
Self-citationBiomechanics of early cardiac development
Goenezen, S., Rennie, M. Y., & Rugonyi, S. (2012) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-012-0414-7 · Cited by 94
Metadata
- Authors
- Mercola, M., & Levin, M.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2001-11
- Volume
- 17
- Issue
- 1
- Pages
- 779-805
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2136704564
- Cited by
- 171
- References
- 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mercola, M., & Levin, M. (2001). Left-Right Asymmetry Determination in Vertebrates. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.17.1.779
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
