Biomechanics of early cardiac development
Open accessAbstract
Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling a more thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.
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The vitelline and allantoic vascular beds offer mechanical resistance to blood flow, and their inadequate growth promotes mechanical signals in the heart that result in structural defects.
“These vascular beds offer mechanical resistance to blood flow, and there is increasing evidence that their inadequate growth promotes mechanical signals in the heart that result in structural defects (218, 260, 341, 379).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [218]
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Flagged first, then by citations
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Cited by
Sorted by citations
Placental Origins of Chronic Disease
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Mechanical regulation of cardiac development
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- Authors
- Goenezen, S., Rennie, M. Y., & Rugonyi, S.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Rugonyi, Sandra
- Venue
- Biomechanics and Modeling in Mechanobiology
- Published
- 2012-07-04
- Volume
- 11
- Issue
- 8
- Pages
- 1187-1204
- ISSN
- 1617-7940 (ISSN-L)
- 1617-7959
- PMC
- PMC3475730
- OpenAlex
- W2074741263
- Cited by
- 94
- References
- 167
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 8
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomechanics and Modeling in Mechanobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL094570)
- Division of Biological Infrastructure
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- heart development, hemodynamics, congenital heart disease, heart looping, cardiac chamber formation, heart valves, hemodynamic loading, mechanobiology, fetal programming, computational modeling, high-resolution imaging
- MeSH terms
- Animals, Computer Simulation, Extracellular Matrix, Heart, Humans, Models, Biological, Stress, Mechanical, Mechanotransduction, Cellular, Embryonic Development
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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