The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nodal Signaling in Vertebrate Development
Abstract
▪ Abstract TGFß signals belonging to the Nodal family set up the embryonic axes, induce mesoderm and endoderm, pattern the nervous system, and determine left-right asymmetry in vertebrates. Nodal signaling activates a canonical TGFß pathway involving activin receptors, Smad2 transcription factors, and FoxH1 coactivators. In addition, Nodal signaling is dependent on coreceptors of the EGF-CFC family and antagonized by the Lefty and Cerberus families of secreted factors. Additional modulators of Nodal signaling include convertases that regulate the generation of the mature signal, and factors such as Arkadia and DRAP1 that regulate the cellular responses to the signal. Complex regulatory cascades and autoregulatory loops coordinate Nodal signaling during early development. Nodals have concentration-dependent roles and can act both locally and at a distance. These studies demonstrate that Nodal signaling is modulated at almost every level to precisely orchestrate tissue patterning during vertebrate embryogenesis.
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759
Cited by
TGF-β Superfamily Signaling in Embryonic Development and Homeostasis
Wu, M. Y., & Hill, C. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.012 · Cited by 746
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
Topczewska, J. M., Postovit, L.-M., Margaryan, N. V., Sam, A., Hess, A. R., Wheaton, W. W., Nickoloff, B. J., Topczewski, J., & Hendrix, M. J. C. (2006) · Nature Medicine · doi:10.1038/nm1448 · Cited by 438
Xiao, L., Yuan, X., & Sharkis, S. J. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0299 · Cited by 353
Control of Directed Cell Migration In Vivo by Membrane-to-Cortex Attachment
Diz-Muñoz, A., Krieg, M., Bergert, M., Ibarlucea-Benitez, I., Muller, D. J., Paluch, E., & Heisenberg, C.-P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000544 · Cited by 271
TGF-β family co-receptor function and signaling
Nickel, J., Ten Dijke, P., & Mueller, T. D. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx126 · Cited by 198
Metadata
- Authors
- Schier, A. F.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2003-11
- Volume
- 19
- Issue
- 1
- Pages
- 589-621
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2095762981
- Cited by
- 633
- References
- 2
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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