The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
PROTEIN TRANSLOCATION BY THE SEC61/SECY CHANNEL
Abstract
The conserved protein-conducting channel, referred to as the Sec61 channel in eukaryotes or the SecY channel in eubacteria and archaea, translocates proteins across cellular membranes and integrates proteins containing hydrophobic transmembrane segments into lipid bilayers. Structural studies illustrate how the protein-conducting channel accomplishes these tasks. Three different mechanisms, each requiring a different set of channel binding partners, are employed to move polypeptide substrates: The ribosome feeds the polypeptide chain directly into the channel, a ratcheting mechanism is used by the eukaryotic endoplasmic reticulum chaperone BiP, and a pushing mechanism is utilized by the bacterial ATPase SecA. We review these translocation mechanisms, relating biochemical and genetic observations to the structures of the protein-conducting channel and its binding partners.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brundage, L., Hendrick, J. P., Schiebel, E., Driessen, A. J. M., & Wickner, W. (1990) · Cell · doi:10.1016/0092-8674(90)90111-q · Cited by 505
Cited by
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
Self-citationStructural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR.
Gelis, I., Bonvin, A. M. J. J., Keramisanou, D., Koukaki, M., Gouridis, G., Karamanou, S., Economou, A., & Kalodimos, C. G. (2007) · Cell · doi:10.1016/j.cell.2007.09.039 · Cited by 433
Golgi Bypass: Skirting Around the Heart of Classical Secretion
Grieve, A. G., & Rabouille, C. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005298 · Cited by 357
Robert, V., Volokhina, E. B., Senf, F., Bos, M. P., Gelder, P. V., & Tommassen, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040377 · Cited by 326
Voigt, F., Zhang, H., Cui, X. A., Triebold, D., Liu, A. X., Eglinger, J., Lee, E. S., Chao, J. A., & Palazzo, A. F. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.008 · Cited by 119
Metadata
- Authors
- Osborne, A. R., Rapoport, T. A., & van den Berg, B.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2005-11-01
- Volume
- 21
- Issue
- 1
- Pages
- 529-550
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2156574575
- Cited by
- 391
- References
- 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: PROTEIN TRANSLOCATION BY THE SEC61/SECY CHANNEL. https://app.cochat.ai/papers/10.1146/annurev.cellbio.21.012704.133214
- The paper
- Osborne, A. R., Rapoport, T. A., & van den Berg, B. (2005). PROTEIN TRANSLOCATION BY THE SEC61/SECY CHANNEL. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.21.012704.133214
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
