Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms

Global analysis of protein expression in yeast

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Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

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Iron-sulfur clusters: nature's modular, multipurpose structures

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Balancing Acts

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Structure, function, and formation of biological iron-sulfur clusters

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The WD repeat: a common architecture for diverse functions

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Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

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Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

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The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins

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Assembly of Iron-Sulfur Clusters

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Cell Biology of Molybdenum

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Mycobacterium Sulfur Metabolism and Implications for Novel Drug Targets

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Iron-Sulfur Protein Assembly in Human Cells

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A diet of oxidative stress–adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK

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Monitoring cysteine level changes under LPS or H2O2 induced oxidative stress using a polymer-based ratiometric fluorescent probe

Jing, X., Yu, F., & Lin, W. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338738 · Cited by 21

Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis

Tripathi, S., Xu, T., Feng, Q. F., Avula, B., Shi, X., Pan, X., Mask, M. M., Baerson, S. R., Jacob, M. R., Ravu, R. R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.781773 · Cited by 21

A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response

Sheng, Y., Yang, G., Casey, K., Curry, S., Oliver, M., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · GeroScience · doi:10.1007/s11357-021-00327-z · Cited by 19

A sensitive and selective red fluorescent probe for imaging of cysteine in living cells and animals

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The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition

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A new lysosome-targeted Cys probe and its application in biology and food samples

Zhang, Y., Chen, X., Sun, H. G., Ai, J., Ren, M., & Kong, F. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.123345 · Cited by 19

In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae

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Interaction between the reductase Tah18 and highly conserved Fe‐S containing Dre2 C‐terminus is essential for yeast viability

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Key Players and Their Role During Mitochondrial Iron–Sulfur Cluster Biosynthesis

Rawat, S., & Stemmler, T. L. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201002143 · Cited by 19

Colorimetric chemosensor based on a carminic acid and Pb2+ complex for selective detection of cysteine over homocysteine and glutathione in aqueous solution

Inoue, K., Aikawa, S., & Fukushima, Y. (2017) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-017-0772-y · Cited by 19

Fe(III) Is Essential for Porcine Embryonic Development via Mitochondrial Function Maintenance

Zhao, M., Liang, S., Kim, S.-H., Cui, X., & Kim, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130791 · Cited by 19

An Iron Balance Dual‐Drive Strategy (IBDS) Promotes Bone Regeneration in Smokers by Regulating Mitochondrial Iron Homeostasis

Xiang, K., Xiao, Z., Zheng, J., Li, Y., Li, M., Su, Z., Huang, Z., Wu, T., He, P., Zhang, Y., et al. (2025) · Advanced Materials · doi:10.1002/adma.202501933 · Cited by 18

ISCU interacts with NFU1, and ISCU[4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1

Cai, K., Frederick, R. O., & Markley, J. L. (2020) · Journal of Structural Biology · doi:10.1016/j.jsb.2020.107491 · Cited by 19

Friedreich Ataxia: An Update on Animal Models, Frataxin Function and Therapies

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Human mitochondrial MIA40 (CHCHD4) is a component of the Fe–S cluster export machinery

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Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron‐recruiting enzyme abundance from cofactor requirements

Dikicioǧlu, D., & Oliver, S. G. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26905 · Cited by 17

[4Fe-4S] cluster trafficking mediated by Arabidopsis mitochondrial ISCA and NFU proteins

Azam, T., Przybyla‐Toscano, J., Vignols, F., Couturier, J., Rouhier, N., & Johnson, M. K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015726 · Cited by 17

Identification of an Alternative Oxidase Induction Motif in the Promoter Region of the aod-1 Gene in Neurospora crassa

Chae, M. S., Lin, C. C., Kessler, K. E., Nargang, C. E., Tanton, L. L., Hahn, L. B., & Nargang, F. E. (2007) · Genetics · doi:10.1534/genetics.106.068635 · Cited by 17

Mitosomes in Parasitic Protists

Tachezy, J., & Šmíd, O. (2007) · Springer eBooks · doi:10.1007/7171_2007_113 · Cited by 17

Lighting up cysteine and homocysteine in sequence based on the kinetic difference of the cyclization/addition reaction

Guo, F., Tian, M., Miao, F., Zhang, W., Song, G., Liu, Y., Yu, X., Sun, J. Z., & Wong, W. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob41414k · Cited by 16

Redox Signaling through DNA

O’Brien, E., Silva, R. M. B., & Barton, J. K. (2016) · Israel Journal of Chemistry · doi:10.1002/ijch.201600022 · Cited by 17

Sef1-Regulated Iron Regulon Responds to Mitochondria-Dependent Iron–Sulfur Cluster Biosynthesis in Candida albicans

Ror, S., & Panwar, S. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01528 · Cited by 17

Oxidative Stress: Cause and Consequence of Diseases

Gospodaryov, D. V., & Lushchak, V. I. (2012) · InTech eBooks · doi:10.5772/38093 · Cited by 18

A New Endoplasmic Reticulum (ER)-Targeting Fluorescent Probe for the Imaging of Cysteine in Living Cells

Zhou, L., Li, Y., Zhou, A., Zhang, G., Cheng, Z., Ge, Y.-X., Liu, S.-K., Azevedo, R. B., Zhang, J., Jiang, S., et al. (2020) · Journal of Fluorescence · doi:10.1007/s10895-020-02615-x · Cited by 15

Ethyl acetate fraction of Tamarindus indica leaf ameliorates aluminium chloride induced neural damage in neonatal Wistar rats

Usman, I. M., Agbon, A. N., Ivang, A. E., Peter, A. B., Afodun, A. M., Okesina, A. A., Fischer, V. A., Sunday, B. Y., Aigbogun, E., Onanuga, I., et al. (2023) · Journal of Trace Elements and Minerals · doi:10.1016/j.jtemin.2023.100047 · Cited by 15

Structural basis for the different activities of yeast Grx1 and Grx2

Li, W., Yu, J., Ma, X.-X., Teng, Y. B., Luo, M., Tang, Y., & Zhou, C. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.04.010 · Cited by 15

Ceramic-polymer coatings on Ti-6Al-4V alloy modified with l-cysteine in biomedical applications

Słota, D., Florkiewicz, W., & Sobczak‐Kupiec, A. (2020) · Materials Today Communications · doi:10.1016/j.mtcomm.2020.101301 · Cited by 14

Effect of chloride driven copper redox cycling on the kinetics of Fe(II) oxidation in aqueous solutions at pH 6.5–8.0

Sun, Y., Pham, A. N., & Waite, T. D. (2015) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2015.03.035 · Cited by 14

Characterization of iron-sulfur cluster assembly protein isca from Acidithiobacillus ferrooxidans

Qian, L., Zheng, C., & Liu, J. (2013) · Biochemistry (Moscow) · doi:10.1134/s000629791303005x · Cited by 14

Design, synthesis, and molecular docking of cysteine-based sulphonamide derivatives as antimicrobial agents

Egbujor, M. C., Okoro, U. C., Okafor, S. N., Egu, S. A., Amasiatu, I. S., Egwuatu, P. I., Umeh, O. R., & Ibo, E. M. (2021) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.329930 · Cited by 14

Metabolic Capacity of Mitochondrion-related Organelles in the Free-living Anaerobic Stramenopile Cantina marsupialis

Noguchi, F., Shimamura, S., Nakayama, T., Yazaki, E., Yabuki, A., Hashimoto, T., Inagaki, Y., Fujikura, K., & Takishita, K. (2015) · Protist · doi:10.1016/j.protis.2015.08.002 · Cited by 15

Robust Production, Crystallization, Structure Determination, and Analysis of [Fe–S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes

Tsai, C.-L., & Tainer, J. A. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.11.006 · Cited by 16

Iron–Sulfur Cluster Biosynthesis in Algae with Complex Plastids

Grosche, C., Diehl, A., Rensing, S. A., & Maier, U. G. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy156 · Cited by 13

A Dynamic Model of the Proteins that Form the Initial Iron-Sulfur Cluster Biogenesis Machinery in Yeast Mitochondria

Amela, I., Delicado, P., Gómez, A., Querol, E., & Cedano, J. A. (2013) · The Protein Journal · doi:10.1007/s10930-013-9475-4 · Cited by 13

A novel fluorescent probe for discrimination of Cys from GSH: inspiration from chemical ligation

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Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome

Neukranz, Y., Kötter, A., Beilschmidt, L. K., Marelja, Z., Helm, M., Gräf, R., & Leimkühler, S. (2019) · Biochemistry · doi:10.1021/acs.biochem.8b01160 · Cited by 13

A Cys-regulated fluorescent probe targeting cancer cells and their application in inflammation detection

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Components of iron–Sulfur cluster assembly machineries are robust phylogenetic markers to trace the origin of mitochondria and plastids

Garcia, P. S., Barras, F., & Gribaldo, S. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002374 · Cited by 13

Cellular Iron Physiology

Muckenthaler, M. U., & Lill, R. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_2 · Cited by 13

Physiological and transcriptional responses in the iron–sulphur cluster assembly pathway under abiotic stress in peach (Prunus persica L.) seedlings

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Therapeutic potential of synthetic and natural iron chelators against ferroptosis

Prabhune, N. M., Ameen, B., & Prabhu, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03640-4 · Cited by 15

Thiol-Independent Action of Mitochondrial Thioredoxin To Support the Urea Cycle of Arginine Biosynthesis in Schizosaccharomyces pombe

Song, J.-Y., Kim, K.-D., & Roe, J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00106-08 · Cited by 14

The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei

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Iba57p participates in maturation of a [2Fe–2S]-cluster Rieske protein and in formation of supercomplexes III/IV of Saccharomyces cerevisiae electron transport chain

Sánchez, L. A., Gómez-Gallardo, M., Díaz-Pérez, A. L., Cortés‐Rojo, C., & Campos‐García, J. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.01.003 · Cited by 12

“Iron priming” guides folding of denatured aporubredoxins

Bonomi, F., Iametti, S., Ferranti, P., Kurtz, D. M. J., Morleo, A., & Ragg, E. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0385-4 · Cited by 11

The Biochemical Adaptations of Mitochondrion-Related Organelles of Parasitic and Free-Living Microbial Eukaryotes to Low Oxygen Environments

Tsaousis, A. D., Leger, M. M., Stairs, C. W., & Roger, A. J. (2011) · Cellular origin and life in extreme habitats · doi:10.1007/978-94-007-1896-8_4 · Cited by 11

Synthesis, Characterization of Some Ferrocenoyl Cysteine and Histidine Conjugates, and Their Interactions with Some Metal Ions

Han, G., Ferranco, A., Feng, X., Chen, Z., & Kraatz, H. (2014) · European Journal of Inorganic Chemistry · doi:10.1002/ejic.201402470 · Cited by 11

Characterization of the sulfur-formation (suf) genes in Synechocystis sp. PCC 6803 under photoautotrophic and heterotrophic growth conditions

Zang, S.-S., Jiang, H., Song, W., Chen, M., & Qiu, B. (2017) · Planta · doi:10.1007/s00425-017-2738-0 · Cited by 11

The Requirement of Inorganic Fe-S Clusters for the Biosynthesis of the Organometallic Molybdenum Cofactor

Mendel, R. R., Hercher, T. W., Zupok, A., Hasnat, M. A., & Leimkühler, S. (2020) · Inorganics · doi:10.3390/inorganics8070043 · Cited by 13

Effect of Mitochondrial and Cytosolic FXN Isoform Expression on Mitochondrial Dynamics and Metabolism

Agrò, M., & Díaz‐Nido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218251 · Cited by 10

Advancements in inhibitors of crucial enzymes in the cysteine biosynthetic pathway: Serine acetyltransferase and O‐acetylserine sulfhydrylase

Qin, Y., Teng, Y., Yang, Y., Mao, Z., Zhao, S., Zhang, N., Li, X., & Niu, W. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14573 · Cited by 9

Overexpression of Schizosaccharomyces pombe tRNA 3′-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death

Shang, J., Wu, L., Yang, Y., Li, Y., Liu, Z., & Huang, Y. K. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.10.003 · Cited by 9

Analysis of manganese-regulated gene expression in the ligninolytic basidiomycete Ceriporiopsis subvermispora

Gutiérrez, M., Rojas, L. A., Mancilla, R. A., Daniela Seelenfreund, H., Vicuña, R., & Sergio Lobos, A. (2008) · Current Genetics · doi:10.1007/s00294-008-0209-7 · Cited by 9

Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

Watanabe, S., Wei, F., & Tomizawa, K. (2013) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2012.12.001 · Cited by 8

Cd-Cysteine Nanorods as a Fluorescence Sensor for Determination of Fe (III) in Real Samples

Ghiamati, E., & Boroujerdi, R. (2015) · Journal of Fluorescence · doi:10.1007/s10895-015-1693-z · Cited by 8

The Evolution History of Fe–S Cluster A-Type Assembly Protein Reveals Multiple Gene Duplication Events and Essential Protein Motifs

Lu, H., Li, J.-D., Zhang, Y.-D., Lü, X.-L., Xu, C., Huang, Y., & Gribskov, M. (2020) · Genome Biology and Evolution · doi:10.1093/gbe/evaa038 · Cited by 8

A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress

Achcar, F., Camadro, J.-M., & Mestivier, D. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-51 · Cited by 8

Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse

Han, N., Kim, N., Kim, H., & Jeong, H. (2015) · Reproductive Sciences · doi:10.1177/1933719115612133 · Cited by 8

Nfu1 Mediated ROS Removal Caused by Cd Stress in Tegillarca granosa

Qian, G., Bao, Y., Li, C., Xie, Q., Lu, M., & Lin, Z. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01061 · Cited by 8

Actualités du métabolisme du fer

Beaumont, C. (2009) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2009.09.020 · Cited by 8

New Advances in Saccharomyces

Morata, A., Loira, I., González, C., & Escott, C. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110980 · Cited by 6

Structural and Functional Characterization of Cystathionine γ-lyase from Bacillus cereus ATCC 14579

Sagong, H.-Y., Kim, B., Joo, S., & Kim, K. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c06503 · Cited by 7

Inherited Disorders of Brain Iron Homeostasis

Schipper, H. M., & Ponka, P. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_15 · Cited by 8

Chronic Psychological Stress Disrupts Iron Metabolism and Enhances Hepatic Mitochondrial Function in Mice

Guo, S., Dong, Y., Cheng, X., Chen, Z., Ni, Y., Zhao, R., & Ma, W. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03269-5 · Cited by 6

Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility

Cao, Y. J., Fu, Y., Ge, C., Xu, W., Zhan, Y., Li, C., Li, W., Wang, X., Wang, Z., Yu, M., et al. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0160 · Cited by 6

Differential expression of iron-sulfur cluster biosynthesis genes during peach flowering

Song, Z., Zhang, B. B., Zhang, C.-H., Ma, R. J., & Yu, M. (2016) · Biologia Plantarum · doi:10.1007/s10535-015-0577-z · Cited by 6

Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis

Wang, X., Chen, X., Sun, L., & Qian, W. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008094 · Cited by 6

Assembling iron-sulfur clusters in the cytosol

Broderick, J. B. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0507-243 · Cited by 6

Mitochondrial Disorders: Nuclear Gene Mutations

Ghezzi, D., & Zeviani, M. (2011) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0005540.pub2 · Cited by 6

Elevated atmospheric CO2 alters the multi-element stoichiometry of pollen-bearing oak flowers, with possible negative effects on bees

Filipiak, Z. M., Mayoral, C., Mills, S. A., Hayward, S. A. L., & Ullah, S. (2024) · Oecologia · doi:10.1007/s00442-024-05610-2 · Cited by 8

Control of Replication Stress Response by Cytosolic Fe-S Cluster Assembly (CIA) Machinery

Frigerio, C., Galli, M., Castelli, S., Prada, A. D., & Clerici, M. (2025) · Cells · doi:10.3390/cells14060442 · Cited by 5

Iron Metabolism in Pathogenic Trypanosomes

Manta, B., Fleitas, L., & Comini, M. A. (2012) · BiblioBoard Library Catalog (Open Research Library) · doi:10.5772/34402 · Cited by 5

Iron–sulfur cluster scaffold (ISCU) gene is duplicated in salmonid fish and tissue and temperature dependent expressed in rainbow trout

Verleih, M., Rebl, A., Köllner, B., Korytář, T., Köbis, J. M., Kühn, C., Wimmers, K., & Goldammer, T. (2012) · Gene · doi:10.1016/j.gene.2012.10.037 · Cited by 5

The Cellular Physiology of Iron

Anderson, G. J., & Vulpe, C. D. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_1 · Cited by 5

Organelles and Trafficking in Entamoeba histolytica

Smith, S. S., & Guillén, N. (2010) · Microbiology monographs · doi:10.1007/978-3-642-12863-9_7 · Cited by 5

Métabolisme du fer : physiologie et pathologie

Beaumont, C., & Girot, R. (2010) · Encyclopédie médico-chirurgicale. Hématologie · doi:10.1016/s1155-1984(10)49948-3 · Cited by 7

News in Ubiquinone Biosynthesis

Rötig, A. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.001 · Cited by 5

Equipping Saccharomyces cerevisiae with an Additional Redox Cofactor Allows F420-Dependent Bioconversions in Yeast

Lee, M., & Fraaije, M. W. (2024) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00718 · Cited by 4

Interaction between Cfd1 and Nbp35 proteins involved in cytosolic Fe S cluster assembly machinery deciphers a stable complexation in Leishmania donovani

Gupta, P., Mansuri, R., Priydarshni, P., Behera, S., Zaidi, A., Nehar, S., Sahoo, G. C., Pandey, K., & Ali, V. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127073 · Cited by 4

Iron-sulfur clusters: Basic building blocks for life

Lill, R. (2007) · Cited by 4

Quantitative Insights into the Crystal Structures of Nitro Derivatives of Ethyl (2E)-2-cyano-3-phenylprop-2-enoate: Inputs from X-Ray Diffraction, DFT Calculations and Hirshfeld Surface Analysis

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