Cited by 365Metalloenzymes and iron-sulfur proteinsMitochondrial Function and PathologyEnzyme Structure and Function

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Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms

Lill, Roland, Mühlenhoff, Ulrich·2006·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.22.010305.104538

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Abstract

Iron-sulfur (Fe/S) clusters require a complex set of proteins to become assembled and incorporated into apoproteins in a living cell. Researchers have described three distinct assembly systems in eukaryotes that are involved in the maturation of cellular Fe/S proteins. Mitochondria are central for biogenesis. They contain the ISC—the iron-sulfur cluster assembly machinery that was inherited from a similar system of eubacteria in evolution and is involved in biogenesis of all cellular Fe/S proteins. The basic principle of mitochondrial (and bacterial) Fe/S protein maturation is the synthesis of the Fe/S cluster on a scaffold protein before the cluster is transferred to apoproteins. Biogenesis of cytosolic and nuclear Fe/S proteins is facilitated by the cytosolic iron-sulfur protein assembly (CIA) apparatus. This process requires the participation of mitochondria that export a still unknown component via the ISC export machinery, including an ABC transporter.

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MnmA and IscS Are Required for in Vitro 2-Thiouridine Biosynthesis in Escherichia coli
Kambampati, R., & Lauhon, C. T. (2003) · Biochemistry · doi:10.1021/bi026536+ · Cited by 168
Erv1p from Saccharomyces cerevisiae is a FAD‐linked sulfhydryl oxidase
Lee, J.-E., Hofhaus, G., & Lisowsky, T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01767-1 · Cited by 167
The eukaryotic P loop NTPase Nbp35: An essential component of the cytosolic and nuclear iron–sulfur protein assembly machinery
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Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation
Biederbick, A., Stehling, O., Rösser, R., Niggemeyer, B., Nakai, Y., Elsässer, H.-P., & Lill, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00112-06 · Cited by 164
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Solution NMR Structure of the Iron–Sulfur Cluster Assembly Protein U (IscU) with Zinc Bound at the Active Site
Ramelot, T. A., Cort, J., Goldsmith‐Fischman, S., Kornhaber, G. J., Xiao, R., Shastry, R., Acton, T., Honig, B. H., Montelione, G. T., & Kennedy, M. A. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.08.038 · Cited by 162
A novel eukaryotic factor for cytosolic Fe–S cluster assembly
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The Essential Mitochondrial Protein Erv1 Cooperates with Mia40 in Biogenesis of Intermembrane Space Proteins
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A second iron-regulatory system in yeast independent of Aft1p
Rutherford, J. C., Jaron, S., Ray, E., Brown, P. O., & Winge, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261381198 · Cited by 153
Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: Evidence that Yfh1p affects Fe-S cluster synthesis
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Evidence for the Transfer of Sulfane Sulfur from IscS to ThiI during the in Vitro Biosynthesis of 4-Thiouridine inEscherichia coli tRNA
Kambampati, R., & Lauhon, C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.10727 · Cited by 151
NifS-Mediated Assembly of [4Fe−4S] Clusters in the N- and C-Terminal Domains of the NifU Scaffold Protein
Smith, A. D., Jameson, G. N. L., Santos, P. C. D., Agar, J. N., Naik, S., Krebs, C., Jeverson Frazzon, B., Dean, D. R., Huynh, B. H., & Johnson, M. K. (2005) · Biochemistry · doi:10.1021/bi051257i · Cited by 148
Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly
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RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila
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Augmenter of Liver Regeneration: A Flavin-Dependent Sulfhydryl Oxidase with CytochromecReductase Activity
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The Arabidopsis Chloroplastic NifU-Like Protein CnfU, Which Can Act as an Iron-Sulfur Cluster Scaffold Protein, Is Required for Biogenesis of Ferredoxin and Photosystem I[W]
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A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
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Yeast Nfs1p Is Involved in Thio-modification of Both Mitochondrial and Cytoplasmic tRNAs
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Solution Structure of the Bacterial Frataxin Ortholog, CyaY
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MTABC3, a Novel Mitochondrial ATP-binding Cassette Protein Involved in Iron Homeostasis
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Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae
Voisine, C., Cheng, Y. C., Ohlson, M. B., Schilke, B. A., Hoff, K. G., Beinert, H., Marszałek, J., & Craig, E. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1483 · Cited by 131
Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: Implications for the mechanism of iron-sulfur cluster assembly
Kato, S.-I., Mihara, H., Kurihara, T., Takahashi, Y., Tokumoto, U., Yoshimura, T., & Esaki, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082123599 · Cited by 130
Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae
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Iron Binding and Oxidation Kinetics in Frataxin CyaY of Escherichia coli
Bou‐Abdallah, F., Adinolfi, S., Pastore, A., Laue, T. M., & Chasteen, N. D. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.072 · Cited by 129
The Essential WD40 Protein Cia1 Is Involved in a Late Step of Cytosolic and Nuclear Iron-Sulfur Protein Assembly
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Ssq1, a Mitochondrial Hsp70 Involved in Iron-Sulfur (Fe/S) Center Biogenesis
Dutkiewicz, R., Schilke, B. A., Knieszner, H., Walter, W. A., Craig, E. A., & Marszałek, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303527200 · Cited by 128
Modular organization and identification of a mononuclear iron-binding site within the NifU protein
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Characterization of Iron-Sulfur Protein Assembly in Isolated Mitochondria
Mühlenhoff, U., Richhardt, N., Gerber, J., & Lill, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204675200 · Cited by 122
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Isa1p Is a Component of the Mitochondrial Machinery for Maturation of Cellular Iron-Sulfur Proteins and Requires Conserved Cysteine Residues for Function
Kaut, A., Lange, H., Diekert, K., Kispál, G., & Lill, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909502199 · Cited by 122
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Adrenodoxin Reductase Homolog (Arh1p) of Yeast Mitochondria Required for Iron Homeostasis
Li, J., Saxena, S., Pain, D., & Dancis, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007198200 · Cited by 122
The Yeast Scaffold Proteins Isu1p and Isu2p Are Required inside Mitochondria for Maturation of Cytosolic Fe/S Proteins
Gerber, J., Neumann, K., Prohl, C., Mühlenhoff, U., & Lill, R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4848-4857.2004 · Cited by 120
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Mechanisms of iron–sulfur cluster assembly: the SUF machinery
Fontecave, M., de Choudens, S. O., Py, B., & Barras, F. (2005) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-005-0025-1 · Cited by 117
An Intestinal Parasitic Protist, Entamoeba histolytica, Possesses a Non-redundant Nitrogen Fixation-like System for Iron-Sulfur Cluster Assembly under Anaerobic Conditions
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A non-essential function for yeast frataxin in iron-sulfur cluster assembly
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Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana.
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Transfer of Iron-Sulfur Cluster from NifU to Apoferredoxin
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How Escherichia coli and Saccharomyces cerevisiae Build Fe/S Proteins
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Friedreich ataxia: a paradigm for mitochondrial diseases
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Mitochondrial Ferredoxin Is Required for Heme A Synthesis inSaccharomyces cerevisiae
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Frataxin and Mitochondrial Carrier Proteins, Mrs3p and Mrs4p, Cooperate in Providing Iron for Heme Synthesis
Zhang, Y., Lyver, E. R., Knight, S. A. B., Lesuisse, E., & Dancis, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500397200 · Cited by 111
The crystal structure of augmenter of liver regeneration: A mammalian FAD‐dependent sulfhydryl oxidase
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Role of the IscU Protein in Iron−Sulfur Cluster Biosynthesis: IscS-mediated Assembly of a [Fe2S2] Cluster in IscU
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Enzymatic Modification of tRNAs
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Hsc66 Substrate Specificity Is Directed toward a Discrete Region of the Iron-Sulfur Cluster Template Protein IscU
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A Mitochondrial-Vacuolar Signaling Pathway in Yeast That Affects Iron and Copper Metabolism
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The Fe/S Assembly Protein IscU Behaves as a Substrate for the Molecular Chaperone Hsc66 from Escherichia coli
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IscA Mediates Iron Delivery for Assembly of Iron-Sulfur Clusters in IscU under the Limited Accessible Free Iron Conditions
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Yeast Erv2p Is the First Microsomal FAD-linked Sulfhydryl Oxidase of the Erv1p/Alrp Protein Family
Gerber, J., Mühlenhoff, U., Hofhaus, G., Lill, R., & Lisowsky, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100134200 · Cited by 106
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Prenylated Prelamin A Interacts with Narf, a Novel Nuclear Protein
Barton, R. M., & Worman, H. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30008 · Cited by 106
Iron−Sulfur Cluster Biosynthesis: Toward an Understanding of Cellular Machinery and Molecular Mechanism
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Iron‐induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo
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SufA from Erwinia chrysanthemi
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Sequence-specific Interaction between Mitochondrial Fe-S Scaffold Protein Isu and Hsp70 Ssq1 Is Essential for Their in Vivo Function
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MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family
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Nfu2: a scaffold protein required for [4Fe‐4S] and ferredoxin iron‐sulphur cluster assembly in Arabidopsis chloroplasts
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A specialized mitochondrial molecular chaperone system:¶A role in formation of Fe/S centers
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Regulatory Roles for IscA and SufA in Iron Homeostasis and Redox Stress Responses in the Cyanobacterium Synechococcus sp. Strain PCC 7002
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Crystal Structure of IscA, an Iron-sulfur Cluster Assembly Protein from Escherichia coli
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MDL1 is a High Copy Suppressor of ATM1: Evidence for a Role in Resistance to Oxidative Stress
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A dimer of the FeS cluster biosynthesis protein IscA from cyanobacteria binds a [2Fe2S] cluster between two protomers and transfers it to [2Fe2S] and [4Fe4S] apo proteins
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Nuclear Localization of Yeast Nfs1p Is Required for Cell Survival
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The genetics of inherited sideroblastic anemias
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Crystal Structure of the Ancient, Fe−S Scaffold IscA Reveals a Novel Protein Fold
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The Cysteine Desulfurase IscS Is Required for Synthesis of All Five Thiolated Nucleosides Present in tRNA from Salmonella enterica Serovar Typhimurium
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Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron–sulfur proteins
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Mitochondrial ABC transporters
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Knock‐out of the cyaY gene in Escherichia coli does not affect cellular iron content and sensitivity to oxidants
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J-domain Protein, Jac1p, of Yeast Mitochondria Required for Iron Homeostasis and Activity of Fe-S Cluster Proteins
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Unique Features of Plant Mitochondrial Sulfhydryl Oxidase
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Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1
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Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds
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Ciao 1 Is a Novel WD40 Protein That Interacts with the Tumor Suppressor Protein WT1
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The Heme Synthesis Defect of Mutants Impaired in Mitochondrial Iron-Sulfur Protein Biogenesis Is Caused by Reversible Inhibition of Ferrochelatase
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The Hsp70 Chaperone Ssq1p Is Dispensable for Iron-Sulfur Cluster Formation on the Scaffold Protein Isu1p
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Characterization of the Interaction between the J-protein Jac1p and the Scaffold for Fe-S Cluster Biogenesis, Isu1p
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The Cell's Cookbook For Iron–Sulfur Clusters: Recipes For Fool's Gold?
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Formation of Thiolated Nucleosides Present in tRNA from Salmonella enterica serovar Typhimurium Occurs in Two Principally Distinct Pathways
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Pse1p Mediates the Nuclear Import of the Iron-responsive Transcription Factor Aft1p in Saccharomyces cerevisiae
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cDNA cloning and characterization of mouse nifS‐like protein, m‐Nfs1: mitochondrial localization of eukaryotic NifS‐like proteins
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Biogenesis of iron–sulfur proteins in eukaryotes: components, mechanism and pathology
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Preferential Substrate Binding Orientation by the Molecular Chaperone HscA
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Iron–sulfur cluster biosynthesis in photosynthetic organisms
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Salmonella enterica Strains Lacking the Frataxin Homolog CyaY Show Defects in Fe-S Cluster Metabolism In Vivo
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Crystal structure of Escherichia coli SufA involved in biosynthesis of iron–sulfur clusters: Implications for a functional dimer
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Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4
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hIscA: a protein implicated in the biogenesis of iron–sulfur clusters
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Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis
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Frataxin and frataxin deficiency in Friedreich's ataxia
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Compensation for a Defective Interaction of the Hsp70 Ssq1 with the Mitochondrial Fe-S Cluster Scaffold Isu
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Biosynthesis of the Nitrogenase Iron- Molybdenum-Cofactor from Azotobacter vinelandii
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The mitochondrial ABC transporter Atm1p functions as a homodimer
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Iron–Sulfur Proteins
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Role of Mitochondrial Carrier Protein Mrs3/4 in Iron Acquisition and Oxidative Stress Resistance of Cryptococcus neoformans
Nyhus, K. J., Ozaki, L. S., & Jacobson, E. S. (2002) · Medical Mycology · doi:10.1080/mmy.40.6.581.591 · Cited by 23
ABC TRANSPORTERS IN MITOCHONDRIA
Lill, R., & Kispál, G. (2003) · Elsevier eBooks · doi:10.1016/b978-012352551-2/50026-3 · Cited by 11
Self-citation

Research works printed but not linked: 2

Frazzon J, 2002, Metal Ion Biol. Syst., 39, 163
10.1080/714031152 · DOI

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See all 365

Authors: Lill, R., & Mühlenhoff, U.
Affiliations: Philipps University of Marburg (DE)
ORCID: Lill, Roland
Mühlenhoff, Ulrich
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2006-11-01
Volume: 22
Issue: 1
Pages: 457-486
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.22.010305.104538
OpenAlex: W2096692378
Cited by: 365
References: 184
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 5 · 2021: 11 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 19 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 20 · 2012: 21
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Bayerische Staatsbibliothek (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: iron-sulfur clusters, mitochondrial iron-sulfur proteins, scaffold proteins, ABC transporters, eukaryotic evolution
MeSH terms: Animals, Bacteria, Eukaryotic Cells, Ferredoxin-NADP Reductase, Iron-Sulfur Proteins, Mitochondria, Saccharomyces cerevisiae

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Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms

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