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THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function

Kennison, James A.·1995·Annual Review of Genetics

Abstract

The Polycomb and trithorax group genes encode trans-regulators of homeotic gene function in Drosophila. The Polycomb group genes encode transcriptional repressors, while the trithorax group proteins are positive factors required for homeotic gene function. Among the Polycomb group proteins, the POLYCOMB protein has been most extensively characterized. The POLYCOMB protein contains a chromodomain, a conserved domain found in a Drosophila protein with effects on position-effect variegation. Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that modifies chromatin to facilitate the transcriptional activation by gene-specific DNA-binding proteins. The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins.

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Metadata

Authors
Kennison, J. A.
Venue
Annual Review of Genetics
Published
1995-12
Volume
29
Issue
1
Pages
289-303
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2174739588
Cited by
402
References
0
FWCI
5.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function. https://app.cochat.ai/papers/10.1146/annurev.ge.29.120195.001445
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Kennison, J. A. (1995). THE POLYCOMB AND TRITHORAX GROUP PROTEINS OF DROSOPHILA: Trans-Regulators of Homeotic Gene Function. Annual Review of Genetics. https://doi.org/10.1146/annurev.ge.29.120195.001445

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