Epigenetic balance of gene expression by Polycomb and COMPASS families
Abstract
A balancing act in modifying chromatin: Chromatin modifiers add chemical groups to histones, the proteins that package DNA. These modifications are central to cellular development, and mutations in their molecular machinery are linked to a variety of human diseases. Piunti and Shilatifard review the balance between the prototypic chromatin modifiers Polycomb and COMPASS complexes and their role in gene regulation and normal development. Although originally identified as indispensible regulators of fruit fly development, related roles have been identified in other organisms. Furthermore, mutations in human homologs have been implicated in various cancers. As such, these complexes may serve as effective targets for epigenetic therapies. Science , this issue p. 10.1126/science.aad9780
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MLL4 exists in a multi-protein complex containing core components WDR5, ASH2L, RBBP5 and DPY30 and other complex-specific proteins such as PAGR1, KDM6A, NCOA6 and PAXIP1.
“MLL4 exists in a multi-protein complex containing the core components WDR5, ASH2L, RBBP5 and DPY3038,39 and other complex-specific proteins, such as PAGR1 (previously known as PA1), KDM6A (UTX), NCOA6 and PAXIP1 (PTIP)37,40.”
From HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements (2024) · cites this paper as [40]
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- Authors
- Piunti, A., & Shilatifard, A.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Shilatifard, Ali
- Venue
- Science
- Published
- 2016-06-03
- Volume
- 352
- Issue
- 6290
- Pages
- aad9780-aad9780
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2419237034
- Cited by
- 524
- References
- 10
- Citations by year
- 2026: 32 · 2025: 46 · 2024: 56 · 2023: 51 · 2022: 58 · 2021: 56 · 2020: 51 · 2019: 48 · 2018: 54 · 2017: 62 · 2016: 10
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R35CA197569)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Polycomb group proteins, Trithorax group proteins, PRC1, polycomb repressive complex 2, chromatin regulation, epigenetic gene expression, chromatin remodeling, transcriptional regulation, developmental gene regulation, human disease
- MeSH terms
- Animals, Chromatin, Chromosomal Proteins, Non-Histone, Drosophila melanogaster, Enhancer Elements, Genetic, Histones, Humans, Methylation, Mutation, Neoplasms, Histone-Lysine N-Methyltransferase, Saccharomyces cerevisiae, Gene Expression, Epigenesis, Genetic, Embryonic Development, Growth and Development, Polycomb-Group Proteins
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