The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes
Abstract
▪ Abstract We review the strategy used to identify a susceptibility locus (IDDM2) for type 1 (insulin dependent) diabetes mellitus. As type 1 diabetes is becoming the paradigm for dissecting multifactorial disease genetics, the approach described provides important general guidelines for positional cloning of human disease polygenes. Main topics include: (a) historical conspectus of the mapping and identification of IDDM2—a critical survey of the work leading up to the conclusion that IDDM2 most likely corresponds to allelic variation at the insulin gene minisatellite (VNTR) locus; (b) the nature of allelic (length and sequence) variation at the VNTR locus; (c) gene interactions and disease pathogenesis; (d) mechanism of action of the INS VNTR in type 1 diabetes—insulin gene expression, parent-of-origin effects (genomic imprinting); and (e) summary and future prospects—alleles of the insulin VNTR that are protective for type 1 diabetes appear to encode susceptibility to type 2 diabetes.
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Cites
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Cited by
Type 1 diabetes: new perspectives on disease pathogenesis and treatment
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Self-citationMapping complex disease traits with global gene expression
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What makes a good genetic association study?
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The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome
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Metadata
- Authors
- Bennett, S. T., & Todd, J. A.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1996-12
- Volume
- 30
- Issue
- 1
- Pages
- 343-370
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2111067855
- Cited by
- 287
- References
- 84
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes. https://app.cochat.ai/papers/10.1146/annurev.genet.30.1.343
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- Bennett, S. T., & Todd, J. A. (1996). HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.30.1.343
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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