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X-CHROMOSOME INACTIVATION IN MAMMALS
Abstract
▪ Abstract The inactive X chromosome differs from the active X in a number of ways; some of these, such as allocyclic replication and altered histone acetylation, are associated with all types of epigenetic silencing, whereas others, such as DNA methylation, are of more restricted use. These features are acquired progressively by the inactive X after onset of initiation. Initiation of X-inactivation is controlled by the X-inactivation center (Xic) and influenced by the X chromosome controlling element (Xce), which causes primary nonrandom X-inactivation. Other examples of nonrandom X-inactivation are also presented in this review. The definition of a major role for Xist, a noncoding RNA, in X-inactivation has enabled investigation of the mechanism leading to establishment of the heterochromatinized X-chromosome and also of the interactions between X-inactivation and imprinting as well as between X-inactivation and developmental processes in the early embryo.
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Citations
Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Boyes, J., & Bird, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05055.x · Cited by 471
Cited by
Aging and epigenetic drift: a vicious cycle
Issa, J.-P. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69735 · Cited by 419
The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors
Juul, K. V., Bichet, D. G., Nielsen, S., & Nørgaard, J. P. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00604.2013 · Cited by 156
Disteche, C. M., Filippova, G. N., & Tsuchiya, K. D. (2002) · Cytogenetic and Genome Research · doi:10.1159/000071572 · Cited by 116
Ohgane, J., Yagi, S., & Shiota, K. (2008) · Placenta · doi:10.1016/j.placenta.2007.09.011 · Cited by 111
Host defenses to transposable elements and the evolution of genomic imprinting
McDonald, J. F., Matzke, M. A., & Matzke, A. J. (2005) · Cytogenetic and Genome Research · doi:10.1159/000084958 · Cited by 51
Metadata
- Authors
- Heard, E., Clerc, P., & Avner, P.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 1997-12
- Volume
- 31
- Issue
- 1
- Pages
- 571-610
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2026556151
- Cited by
- 525
- References
- 2
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heard, E., Clerc, P., & Avner, P. (1997). X-CHROMOSOME INACTIVATION IN MAMMALS. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.31.1.571
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.