The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Sequence Divergence, Functional Constraint, and Selection in Protein Evolution
Abstract
The genome sequences of multiple species has enabled functional inferences from comparative genomics. A primary objective is to infer biological functions from the conservation of homologous DNA sequences between species. A second, more difficult, objective is to understand what functional DNA sequences have changed over time and are responsible for species' phenotypic differences. The neutral theory of molecular evolution provides a theoretical framework in which both objectives can be explicitly tested. Development of statistical tests within this framework has provided insight into the evolutionary forces that constrain and in some cases change DNA sequences and the resulting patterns that emerge. In this article, we review recent work on how functional constraint and changes in protein function are inferred from protein polymorphism and divergence data. We relate these studies to our understanding of the neutral theory and adaptive evolution.
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Cites
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Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568
Molecular Signatures of Natural Selection
Nielsen, R. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.112420 · Cited by 1,641
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiss, G., Lachmann, M., & Pääbo, S. (2005) · Science · doi:10.1126/science.1108296 · Cited by 592
Evidence That Mutation Is Universally Biased towards AT in Bacteria
Hershberg, R., & Petrov, D. A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001115 · Cited by 490
Plasma AR and abiraterone-resistant prostate cancer
Romanel, A., Tandefelt, D. G., Conteduca, V., Jayaram, A., Casiraghi, N., Wetterskog, D., Salvi, S., Amadori, D., Zafeiriou, Z., Rescigno, P., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac9511 · Cited by 441
Metadata
- Authors
- Fay, J. C., & Wu, C.-I.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2003-09
- Volume
- 4
- Issue
- 1
- Pages
- 213-235
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2115759361
- Cited by
- 294
- References
- 103
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fay, J. C., & Wu, C.-I. (2003). Sequence Divergence, Functional Constraint, and Selection in Protein Evolution. Annual Review of Genomics and Human Genetics. https://doi.org/10.1146/annurev.genom.4.020303.162528
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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