The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
NK CELL RECEPTORS
Abstract
▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I. Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules. A common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors. Upon ligand binding and activation, the inhibitory NK cell receptors become tyrosine phosphorylated and recruit tyrosine phosphatases, SHP-1 and possibly SHP-2, resulting in inhibition of NK cell–mediated cytotoxicity and cytokine expression. Recent studies suggest these inhibitory NK cell receptors are members of a larger superfamily containing ITIM sequences, the inhibitory receptor superfamily (IRS).
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1 retracted
Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
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RetractedRAG-1-deficient mice have no mature B and T lymphocytes
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CD28/B7 SYSTEM OF T CELL COSTIMULATION
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Self-citation
Cited by
Of Mice and Not Men: Differences between Mouse and Human Immunology
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Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
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The biology of human natural killer-cell subsets
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Self-citationMolecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Metadata
- Authors
- Lanier, L. L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1998-04
- Volume
- 16
- Issue
- 1
- Pages
- 359-393
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2160520392
- Cited by
- 1,648
- References
- 212
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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