The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION
Abstract
▪ Abstract Dynamic protein-protein interactions are a key component of biological regulatory networks. Dimerization events—physical interactions between related proteins—represent an important subset of protein-protein interactions and are frequently employed in transducing signals from the cell surface to the nucleus. Importantly, dimerization between different members of a protein family can generate considerable functional diversity when different protein combinations have distinct regulatory properties. A survey of processes known to be controlled by dimerization illustrates the diverse physical and biological outcomes achieved through this regulatory mechanism. These include: facilitated proximity and orientation; differential regulation by heterodimerization; generation of temporal and spatial boundaries; enhancement of specificity; and regulated monomer-to-dimer transitions. Elucidation of these mechanisms has led to the design of new approaches to study and to manipulate signal transduction pathways.
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Metadata
- Authors
- Klemm, J. D., Schreiber, S. L., & Crabtree, G. R.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1998-04
- Volume
- 16
- Issue
- 1
- Pages
- 569-592
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2139823369
- Cited by
- 323
- References
- 105
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION. https://app.cochat.ai/papers/10.1146/annurev.immunol.16.1.569
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- Klemm, J. D., Schreiber, S. L., & Crabtree, G. R. (1998). DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.16.1.569
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
