Constitutive activation of STAT 3 in breast cancer cells: A review

Banerjee, Kasturi; Resat, Haluk

doi:10.1002/ijc.29923

Cited by 611Cytokine Signaling Pathways and InteractionsTGF-β signaling in diseasesNF-κB Signaling Pathways

Constitutive activation of STAT 3 in breast cancer cells: A review

Open access

Banerjee, Kasturi, Resat, Haluk·2016·International Journal of Cancer

DOI 10.1002/ijc.29923PMC PMC4801660

Open this paper in CoChat — free account

Abstract

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in numerous cancer types, including more than 40% of breast cancers. In contrast to tight regulation of STAT3 as a latent transcription factor in normal cells, its signaling in breast cancer oncogenesis is multifaceted. Signaling through the IL‐6/JAK/STAT3 pathway initiated by the binding of IL‐6 family of cytokines (i.e., IL‐6 and IL‐11) to their receptors have been implicated in breast cancer development. Receptors with intrinsic kinase activity such as EGFR and VEGFR directly or indirectly induce STAT3 activation in various breast cancer types. Aberrant STAT3 signaling promotes breast tumor progression through deregulation of the expression of downstream target genes which control proliferation (Bcl‐2, Bcl‐xL, Survivin, Cyclin D1, c‐Myc and Mcl‐1), angiogenesis (Hif1α and VEGF) and epithelial–mesenchymal transition (Vimentin, TWIST, MMP‐9 and MMP‐7). These multiple modes of STAT3 regulation therefore make it a central linking point for a multitude of signaling processes. Extensive efforts to target STAT3 activation in breast cancer had no remarkable success in the past because the highly interconnected nature of STAT3 signaling introduces lack of selectivity in pathway identification for STAT3 targeted molecular therapies or because its role in tumorigenesis may not be as critical as it was thought. This review provides a full spectrum of STAT3's involvement in breast cancer by consolidating the knowledge about its role in breast cancer development at multiple levels: its differential regulation by different receptor signaling pathways, its downstream target genes, and modification of its transcriptional activity by its coregulatory transcription factors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/ijc.29923

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Elevated levels of STAT3 are observed in many solid and hematologic tumors, where its signaling underpins majority of cardinal features of cancer, including growth, antiapoptosis, transformation, angiogenesis, metastasis, and cancer stem cell maintenance.
“Elevated levels of STAT3 have been observed in a large number of both solid and hematologic tumors, where its signaling underpins a majority of all known cardinal features of cancer (Yuan et al., 2015b), including growth and proliferation (Banerjee and Resat, 2016), antiapoptosis (Gritsko et al., 2006), cell transformation (Bromberg et al., 1999), angiogenesis (Doucette et al., 2012), metastasis (”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Banerjee and Resat, 2016
This provides a strong link between pro-inflammatory immune factors, body growth through activation of the mTOR pathway and uncontrolled proliferation typical of cancer-related disease.
“This provides a strong link between pro-inflammatory immune factors, body growth through activation of the mTOR pathway and uncontrolled proliferation typical of cancer-related disease [150, 151–153].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [153]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,856 · see citing works
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Marotta, L. L. C., Almendro, V., Marusyk, A., Shipitsin, M. V., Schemme, J., Walker, S. R., Bloushtain-Qimron, N., Kim, J. J., Choudhury, S. A., Maruyama, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44745 · Cited by 913 · see citing works
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
Sansone, P., Storci, G., Tavolari, S., Guarnieri, T., Giovannini, C., Taffurelli, M., Ceccarelli, C., Santini, D., Paterini, P., Marcu, K. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32533 · Cited by 779 · see citing works
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro‐Cacho, C., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S. J., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204349 · Cited by 747 · see citing works
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
Zhou, J., Wulfkuhle, J. D., Zhang, H., Gu, P., Yang, Y., Deng, J., Margolick, J. B., Liotta, L. A., Petricoin, E., & Zhang, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702596104 · Cited by 699 · see citing works
Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
Lee, M. J., Ye, A. S., Gardino, A. K., Heijink, A. M., Sorger, P. K., MacBeath, G., & Yaffe, M. B. (2012) · Cell · doi:10.1016/j.cell.2012.03.031 · Cited by 681 · see citing works
Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression
Lo, H., Hsu, S.-C., Xia, W., Cao, X., Shih, J., Wei, Y., Abbruzzese, J. L., Hortobágyi, G. N., & Hung, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0575 · Cited by 625 · see citing works
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E., & Stark, G. R. (2007) · Genes & Development · doi:10.1101/gad.1553707 · Cited by 611 · see citing works
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
Gritsko, T., Williams, A., Turkson, J., Kaneko, S., Bowman, T., Huang, M., Nam, S., Eweis, I., Diaz, N., Sullivan, D., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1752 · Cited by 563 · see citing works
STAT3 Target Genes Relevant to Human Cancers
Carpenter, R., & Lo, H.-W. (2014) · Cancers · doi:10.3390/cancers6020897 · Cited by 511 · see citing works
Janus kinases: components of multiple signaling pathways
Rane, S. G., & Reddy, E. (2000) · Oncogene · doi:10.1038/sj.onc.1203925 · Cited by 504 · see citing works
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis
Chang, Q., Bournazou, E., Sansone, P., Berishaj, M., Gao, S. P., Daly, L., Wels, J., Theilen, T., Granitto, S., Zhang, X., et al. (2013) · Neoplasia · doi:10.1593/neo.13706 · Cited by 494 · see citing works
Regulation of MAPKs by growth factors and receptor tyrosine kinases
Katz, M., Amit, I., & Yarden, Y. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.002 · Cited by 468 · see citing works
Leptin--A Growth Factor in Normal and Malignant Breast Cells and for Normal Mammary Gland Development
Hu, X. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.22.1704 · Cited by 451 · see citing works
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
Turkson, J., Ryan, D., Kim, J. S., Zhang, Y., Chen, Z. J., Haura, E. B., Laudano, A., Sebti, S. M., Hamilton, A. D., & Jove, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107527200 · Cited by 448 · see citing works
Targeting STAT3 in cancer: how successful are we?
Yue, P.-B., & Turkson, J. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780802565791 · Cited by 425 · see citing works
Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8
Hartman, Z. C., Poage, G. M., den Hollander, P., Tsimelzon, A. I., Hill, J. L., Panupinthu, N., Zhang, Y., Mazumdar, A., Hilsenbeck, S. G., Mills, G. B., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4524-t · Cited by 408 · see citing works
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
He, B., You, L., Uematsu, K., Zang, K., Xu, Z., Lee, A. Y., Costello, J. F., McCormick, F., & Jablons, D. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232790100 · Cited by 380 · see citing works
The role of intratumoral and systemic IL-6 in breast cancer
Dethlefsen, C., Højfeldt, G. W., & Højman, P. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2488-z · Cited by 363 · see citing works
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
Niwa, Y., Kanda, H., Shikauchi, Y., Saiura, A., Matsubara, K., Kitagawa, T., Yamamoto, J., Kubo, T., & Yoshikawa, H. (2005) · Oncogene · doi:10.1038/sj.onc.1208788 · Cited by 358 · see citing works
DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION
Klemm, J. D., Schreiber, S. L., & Crabtree, G. R. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.569 · Cited by 323 · see citing works
Leptin in human physiology and therapeutics
Dardeno, T. A., Chou, S. H.-H., Moon, H., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.06.002 · Cited by 288 · see citing works
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
Kotha, A., Sekharam, M., Cilenti, L., Siddiquee, K., Khaled, A. R., Zervos, A. S., Carter, B., Turkson, J., & Jove, R. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0268 · Cited by 287 · see citing works
PIAS/SUMO: new partners in transcriptional regulation
Schmidt, D., & M�ller, S. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3129-1 · Cited by 285 · see citing works
Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3
Leslie, K., Lang, C., Devgan, G., Azare, J., Berishaj, M., Gerald, W., Kim, Y. B., Paz, K., Darnell, J. E., Albanese, C., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2203 · Cited by 285 · see citing works
IL-6 involvement in epithelial cancers
Schafer, Z. T., & Brugge, J. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci34237 · Cited by 267 · see citing works
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2
Zhao, D., Pan, C., Sun, J., Gilbert, C. A., Drews‐Elger, K., Azzam, D. J., Picon‐Ruiz, M., Kim, M., Ullmer, W., El‐Ashry, D., et al. (2014) · Oncogene · doi:10.1038/onc.2014.257 · Cited by 264 · see citing works
Role of Notch and its oncogenic signaling crosstalk in breast cancer
Guo, S., Liu, M., & Gonzalez-Perez, R. R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.12.002 · Cited by 260 · see citing works
Vascular endothelial growth factor receptor-2 in breast cancer
Guo, S., Colbert, L. S., Fuller, M. H., Zhang, Y., & Gonzalez-Perez, R. R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.04.004 · Cited by 248 · see citing works
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression
Diaz, N., Minton, S. E., Cox, C., Bowman, T. L., Gritsko, T., Garcia, R., Eweis, I., Wloch, M., Livingston, S., Seijo, E., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1749 · Cited by 241 · see citing works
Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
Berishaj, M., Gao, S. P., Ahmed, S. T., Leslie, K., Al‐Ahmadie, H. A., Gerald, W. L., Bornmann, W. G., & Bromberg, J. (2007) · Breast Cancer Research · doi:10.1186/bcr1680 · Cited by 236 · see citing works
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
Pawlus, M. R., Wang, L., & Hu, C. (2013) · Oncogene · doi:10.1038/onc.2013.115 · Cited by 224 · see citing works
Interleukin‐6 is a potent growth factor for ER‐α‐positive human breast cancer
Sasser, A. K., Sullivan, N. J., Studebaker, A. W., Hendey, L. F., Axel, A. E., & Hall, B. M. (2007) · The FASEB Journal · doi:10.1096/fj.07-8832com · Cited by 222 · see citing works
Knockdown of STAT3 Expression by RNA Interference Inhibits the Induction of Breast Tumors in Immunocompetent Mice
Ling, X., & Arlinghaus, R. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2425 · Cited by 202 · see citing works
Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line
Laud, K., Gourdou, I., Pessemesse, L., et al. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00678-5 · Cited by 191 · see citing works
A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways
Morton, S. W., Lee, M. J., Deng, Z. J., Dreaden, E. C., Siouve, E., Shopsowitz, K. E., Shah, N. J., Yaffe, M. B., & Hammond, P. T. (2014) · Science Signaling · doi:10.1126/scisignal.2005261 · Cited by 190 · see citing works
Leptin expression in colorectal and breast cancer patients.
Tessitore, L., Vizio, B., Jenkins, O., Stefano, I. S. D., Ritossa, C., Argilés, J. M. A., Benedetto, C., & Mussa, A. M. A. (2000) · International Journal of Molecular Medicine · doi:10.3892/ijmm.5.4.421 · Cited by 186 · see citing works
An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells
Jiang, P., Enomoto, A., Jijiwa, M., Kato, T., Hasegawa, T., Ishida, M., Sato, T., Asai, N., Murakumo, Y., & Takahashi, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5111 · Cited by 176 · see citing works
STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits
CHUNG, S. S., Giehl, N. M., Wu, Y., & Vadgama, J. V. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2195 · Cited by 161 · see citing works
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways
Miller, T. W., & Hosford, S. R. (2014) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s52762 · Cited by 145 · see citing works
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways
(2014) · Pharmacogenomics and Personalized Medicine · Cited by 145 · see citing works
The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer
Bishop, J. L., Thaper, D., & Zoubeidi, A. (2014) · Cancers · doi:10.3390/cancers6020829 · Cited by 141 · see citing works
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
Jin, S., Mutvei, A. P., Chivukula, I. V., Andersson, E. R., Ramsköld, D., Sandberg, R., Lee, K. L., Kronqvist, P., Mamaeva, V., Östling, P., et al. (2012) · Oncogene · doi:10.1038/onc.2012.517 · Cited by 141 · see citing works
HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis
Hartman, Z. C., Yang, X.-Y., Glass, O., Lei, G., Osada, T., Dave, S. S., Morse, M. A., Clay, T. M., & Lyerly, H. K. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0308 · Cited by 137 · see citing works
EGFR dependent expression of STAT3 (but not STAT1) in breast cancer.
Berclaz, G., Altermatt, H., Rohrbach, V., Siragusa, A., Dreher, E., & Smith, P. D. (2001) · International Journal of Oncology · doi:10.3892/ijo.19.6.1155 · Cited by 131 · see citing works
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer.
Wu, D., Foreman, T. L., Gregory, C. W., et al. (2002) · PubMed · Cited by 121 · see citing works
Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice
Lee, C., Dhillon, J., Wang, M. Y. C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1082 · Cited by 121 · see citing works
Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression
Chang, C.-C., Chang, C.-C., Wu, M.-J., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3076 · Cited by 116 · see citing works
Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer
Walker, S. R., Xiang, M. H., & Frank, D. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.010 · Cited by 115 · see citing works
Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3
Béguelin, W., Flaqué, M. C. D., Proietti, C. J., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00012-10 · Cited by 110 · see citing works
Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2)
Aziz, M. H., Hafeez, B. B., Sand, J. M., et al. (2010) · Oncogene · doi:10.1038/onc.2010.63 · Cited by 103 · see citing works
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Ren, Z. J., & Schaefer, T. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112438200 · Cited by 102 · see citing works
TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers
Shields, B. J., Wiede, F., Gurzov, E. N., Wee, K., Hauser, C., Zhu, H., Molloy, T. J., O'Toole, S. A., Daly, R. J., Sutherland, R. L., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01016-12 · Cited by 95 · see citing works
STAT3 can be activated through paracrine signaling in breast epithelial cells
Lieblein, J., Ball, S., Hutzen, B. J., Sasser, A., Lin, H.-J., Huang, T. H., Hall, B. M., & Lin, J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-302 · Cited by 93 · see citing works
Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene
Song, Y., Lu, Q., Song, S., Chen, L., Zhang, Y., Yuan, G., Zhang, H., Xia, Q., Hu, M., Yu, M., et al. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.031 · Cited by 80 · see citing works
Leptin’s Pro-Angiogenic Signature in Breast Cancer
Gonzalez-Perez, R. R., Lanier, V., & Newman, G. W. (2013) · Cancers · doi:10.3390/cancers5031140 · Cited by 79 · see citing works
Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer
Rao (2009) · International Journal of Oncology · doi:10.3892/ijo_00000249 · Cited by 75 · see citing works
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer
Su, F., Ren, F., Rong, Y., Wang, Y., Geng, Y., Wang, Y., Feng, M., Ju, Y., Li, Y., Zhao, Z. J., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3134 · Cited by 72 · see citing works
Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
Kim, S., Nagalingam, A., Saxena, N. K., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq267 · Cited by 67 · see citing works
The Scientific Drunk and the Lamppost: Massive Sequencing Efforts in Cancer Discovery and Treatment
Yaffe, M. B. (2013) · Science Signaling · doi:10.1126/scisignal.2003684 · Cited by 67 · see citing works
ErbB2-Mediated Src and Signal Transducer and Activator of Transcription 3 Activation Leads to Transcriptional Up-Regulation of p21Cip1 and Chemoresistance in Breast Cancer Cells
Hawthorne, V. S., Huang, W.-C., Neal, C. L., Tseng, L.-M., Hung, M., & Yu, D. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0316 · Cited by 65 · see citing works
Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells
Gu, J., Li, G., Sun, T., Su, Y., Zhang, X., Shen, J., Tian, Z., & Zhang, J. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9590-9 · Cited by 61 · see citing works
Relationship between IL-10 and tumor markers in breast cancer patients
Fernández, L. L., Goyanes, R. I. Á., Arango-Prado, M. D. C., Alcocer-González, J. M., Mojarrieta, J. C., Pérez, X. E., López, M. O., Odio, S. F., Rodríguez, R. C., Guerra-Yi, M. E., et al. (2006) · The Breast · doi:10.1016/j.breast.2005.09.012 · Cited by 58 · see citing works
A Signal Transducer and Activator of Transcription 3·Nuclear Factor κB (Stat3·NFκB) Complex Is Necessary for the Expression of Fascin in Metastatic Breast Cancer Cells in Response to Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α*
Snyder, M., Huang, J., Huang, X.-Y., & Zhang, J. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591719 · Cited by 57 · see citing works
Interleukin-32β stimulates migration of MDA-MB-231 and MCF-7cells via the VEGF-STAT3 signaling pathway
Park, J. S., Choi, S. Y., Lee, J.-H., Lee, M., Nam, E. S., Jeong, A. L., Lee, S., Han, S., Lee, M. S., Lim, J., et al. (2013) · Cellular Oncology · doi:10.1007/s13402-013-0154-4 · Cited by 57 · see citing works
Protein Kinase C ε Is an Endogenous Photosensitizer That Enhances Ultraviolet Radiation-Induced Cutaneous Damage and Development of Squamous Cell Carcinomas1
Wheeler, D. L., Martin, K. E., Ness, K. J., Li, Y., Dreckschmidt, N. E., Wartman, M. A., Ananthaswamy, H. N., Mitchell, D. L., & Verma, A. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1881 · Cited by 53 · see citing works
Inhibitory receptor immunoglobulin-like transcript 4 was highly expressed in primary ductal and lobular breast cancer and significantly correlated with IL-10
Liu, J., Wang, L., Gao, W., Li, L., Cui, X., Yang, H., Lin, W., Dang, Q., Zhang, N., & Sun, Y. (2014) · Diagnostic Pathology · doi:10.1186/1746-1596-9-85 · Cited by 51 · see citing works
Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors
Tell, R. W., & Horvath, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404881111 · Cited by 50 · see citing works
miRNA-21 inhibition enhances RANTES and IP-10 release in MCF-7 via PIAS3 and STAT3 signalling and causes increased lymphocyte migration
Wang, Z., Han, J., Cui, Y., Zhou, X., & Fan, K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.072 · Cited by 49 · see citing works
Association of interleukin-10 gene polymorphisms with breast cancer in a Chinese population
Fanjun, K., Liu, J., Liu, Y., et al. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-72 · Cited by 49 · see citing works
Oncostatin M-specific receptor mediates inhibition of breast cancer cell growth and down-regulation of the c-myc proto-oncogene.
Liu, J., Spence, M. J., Wallace, P. M., Forcier, K., Hellström, I., & Vestal, R. E. (1997) · PubMed · Cited by 49 · see citing works
The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition
Wang, X., Zhang, Y., ZHANG, X., Tian, W., Feng, W., & Chen, T. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1298 · Cited by 48 · see citing works
STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis
Dunkel, Y., Ong, A., Notani, D., Mittal, Y., Lam, M. T. Y., Mi, X., & Ghosh, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390781 · Cited by 47 · see citing works
STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes
Zhang, X., Zhang, J., Wei, H., & Tian, Z. (2007) · Oncology Reports · doi:10.3892/or.17.6.1377 · Cited by 41 · see citing works
Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis
Nakagawa, T., Iida, S., Osanai, T., Uetake, H., Aruga, T., Toriya, Y., Takagi, Y., Kawachi, H., & Sugihara, K. (2008) · Oncology Reports · doi:10.3892/or.19.1.33 · Cited by 41 · see citing works
HER2-dependent MMP-7 expression is mediated by activated STAT3
Yuan, G., Lü, Q., Shi, M., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.02.017 · Cited by 38 · see citing works
cmvIL-10 Stimulates the Invasive Potential of MDA-MB-231 Breast Cancer Cells
Oseguera, C. A. V., & Spencer, J. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088708 · Cited by 36 · see citing works
The Intracellular Delivery of a Recombinant Peptide Derived from the Acidic Domain of PIAS3 Inhibits STAT3 Transactivation and Induces Tumor Cell Death
Borghouts, C., Tittmann, H., Delis, N., Kirchenbauer, M., Brill, B., & Groner, B. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0417 · Cited by 34 · see citing works
Girdin protein: a new potential distant metastasis predictor of breast cancer
Liu, C., Zhang, Y., Xu, H., et al. (2011) · Medical Oncology · doi:10.1007/s12032-011-0087-6 · Cited by 33 · see citing works
A Novel Unidirectional Cross-Talk from the Insulin-Like Growth Factor-I Receptor to Leptin Receptor in Human Breast Cancer Cells
Ozbay, T., & Nahta, R. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2126 · Cited by 32 · see citing works
Increased levels of active c-Src distinguish invasive from in situ lobular lesions
Zou, D., Yoon, H., Anjomshoaa, A., et al. (2009) · Breast Cancer Research · doi:10.1186/bcr2332 · Cited by 29 · see citing works
Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk
Liu, L., Su, C.-H., Wang, H.-C., et al. (2014) · Biomedicine · doi:10.7603/s40681-014-0003-4 · Cited by 23 · see citing works
JAK2, STAT3 and SOCS3 gene expression in women with and without breast cancer
Benítez, J. G. S., Zerón, H. M., Gómez‐Oliván, L. M., Quiroz, Á. O., Torres-Juárez, J. J., & González-Bañales, J. M. (2014) · Gene · doi:10.1016/j.gene.2014.06.025 · Cited by 22 · see citing works
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Lim, J.-H. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2014.18.5.391 · Cited by 17 · see citing works
Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells
Gong, C., Zhang, Y., Shankaran, H., & Resat, H. (2014) · Molecular BioSystems · doi:10.1039/c4mb00471j · Cited by 17 · see citing works
Self-citation
The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells
Palianopoulou, M., Papanikolaou, V., Stefanou, N., & Tsezou, A. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010224 · Cited by 17 · see citing works
Telomerase and telomere stability: A new class of tumor suppressor?
Elmore, L. W., & Holt, S. E. (2000) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(200005)28:1 · Cited by 15 · see citing works
Preliminary characterization of IL32 in basal-like/triple negative compared to other types of breast cell lines and tissues
Player, A. N., Oguamanam, T., Okanmelu, J., et al. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-501 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Bai, L., Zhou, H., Xu, R., Zhao, Y., Chinnaswamy, K., McEachern, D., Chen, J., Yang, C.-Y., Liu, Z., Wang, M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.002 · Cited by 652 · see citing works
Cancer-associated adipocytes: key players in breast cancer progression
Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462 · see citing works
The ASD Living Biology: from cell proliferation to clinical phenotype
Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“, 2015b), including growth and proliferation (Banerjee and Resat, 2016), antiapoptosis (Gritsko et al.”
Background
JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies
Rah, B., Rather, R. A., Bhat, G. R., Baba, A. B., Mushtaq, I., Farooq, M., Yousuf, T., Dar, S. B., Parveen, S., Hassan, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.821344 · Cited by 202 · see citing works
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1
Cai, X., Cao, C., Li, J., Chen, F., Zhang, S., Liu, B., Zhang, W., Zhang, X., & Ye, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16873 · Cited by 111 · see citing works
Activation of the IL-6/JAK2/STAT3 pathway induces plasma cell mastitis in mice.
Liu, Y., Zhang, J., Zhou, Y.-H., Zhang, H.-M., Wang, K., Ren, Y., Jiang, Y.-N., Han, S.-P., He, J.-J., & Tang, X.-J. (2018) · Cytokine · doi:10.1016/j.cyto.2018.05.002 · Cited by 46 · see citing works
Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells
Valle Oseguera, C. A., & Spencer, J. V. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0399-5 · Cited by 24 · see citing works

Authors: Banerjee, K., & Resat, H.
Affiliations: Washington State University (US)
Corresponding author: Resat, Haluk
ORCID: Resat, Haluk
Venue: International Journal of Cancer
Publisher: Wiley
Published: 2015-11-28
Volume: 138
Issue: 11
Pages: 2570-2578
ISSN: 0020-7136 (ISSN-L)
1097-0215
DOI: 10.1002/ijc.29923
PMC: PMC4801660
OpenAlex: W2113231588
Cited by: 611
References: 90
Citations by year: 2026: 22 · 2025: 41 · 2024: 39 · 2023: 70 · 2022: 56 · 2021: 79 · 2020: 111 · 2019: 79 · 2018: 59 · 2017: 42 · 2016: 13
FWCI: 4.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5R01GM072821)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT3, breast cancer, constitutive activation, IL-6/JAK/STAT3 signaling, EGFR, VEGFR, oncogenic signaling, tumor progression, angiogenesis, epithelial-mesenchymal transition, downstream target genes
MeSH terms: Breast Neoplasms, Female, Humans, Signal Transduction, Transcriptional Activation, Interleukin-6, Gene Expression Regulation, Neoplastic, Vascular Endothelial Growth Factor Receptor-1, STAT3 Transcription Factor, Janus Kinases, ErbB Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Constitutive activation of STAT 3 in breast cancer cells: A review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks