The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Population Biology of Lymphocytes: The Flight for Survival
Open accessAbstract
In this essay we suggest that the primary goal of the cells of the immune system is to ensure their own growth and survival. In adults, in steady-state conditions, the number and distribution of lymphocyte populations is under homeostatic control. New lymphocytes that are continuously produced in primary and secondary lymphoid organs must compete with resident cells for survival. We discuss recent findings supporting lymphocyte survival as a continuous active process and implicating cognate receptor engagement as fundamental survival signals for both T and B lymphocytes. The conflict of survival interests between different cell types gives rise to a pattern of interactions that mimics the behavior of complex ecological systems. In their flight for survival and in response to competition, lymphocytes use different survival signals within different ecological niches during cell differentiation. This is the case for T and B lymphocytes and also for naive and memory/activated T and B cells. We discuss how niche differentiation allows the co-existence of different cell types and guarantees both repertoire diversity and efficient immune responses.
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(1976) · Cited by 10,423
Evolution and the Theory of Games
Smith, J. M. (1988) · Did Darwin Get It Right? · doi:10.1007/978-1-4684-7862-4_22 · Cited by 7,906
Evolution and the Theory of Games
Smith, J. M. (1982) · Cambridge University Press eBooks · doi:10.1017/cbo9780511806292 · Cited by 6,922
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,332
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,820
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,274
Resource Competition and Community Structure
Hassell, M. P., & Tilman, D. (1984) · The Journal of Animal Ecology · doi:10.2307/4549 · Cited by 4,176
Hanski, L. (1999) · doi:10.1093/oso/9780198540663.001.0001 · Cited by 3,535
Ecology: Individuals, Populations and Communities.
Pickett, S. T. A., Carson, W. P., Begon, M., Harper, J. L., & Townsend, C. R. (1987) · Brittonia · doi:10.2307/2807146 · Cited by 3,157
‘Actively Acquired Tolerance’ of Foreign Cells
BILLINGHAM, R. E., BRENT, L., & MEDAWAR, P. B. (1953) · Nature · doi:10.1038/172603a0 · Cited by 3,136
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The Influence of Age on T Cell Generation and TCR Diversity
Naylor, K., Li, G., Vallejo, A. N., Lee, W.-W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C. M., & Goronzy, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7446 · Cited by 802
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572
Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells
Goldrath, A. W., Sivakumar, P. V., Glaccum, M., Kennedy, M. K., Bevan, M. J., Benoist, C., Mathis, D., & Butz, E. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020033 · Cited by 587
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Metadata
- Authors
- Freitas, A. A., & Rocha, B.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 83-111
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2163955606
- Cited by
- 426
- References
- 139
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
