The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tolerance, Danger, and the Extended Family
Abstract
For many years immunologists have been well served by the viewpoint that the immune system's primary goal is to discriminate between self and non-self. I believe that it is time to change viewpoints and, in this essay, I discuss the possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues.
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Citations
Cites
The Protection: The Unit of Humoral Immunity Selected by Evolution
Cohn, M., & Langman, R. E. (1990) · Immunological Reviews · doi:10.1111/j.1600-065x.1990.tb00783.x · Cited by 238
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Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475
Cancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
The Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205
Self-citationCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Metadata
- Authors
- Matzinger, P.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1994-04
- Volume
- 12
- Issue
- 1
- Pages
- 991-1045
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2158500407
- Cited by
- 4,820
- References
- 1
- FWCI
- 30.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Matzinger, P. (1994). Tolerance, Danger, and the Extended Family. Annual Review of Immunology. https://doi.org/10.1146/annurev.iy.12.040194.005015
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
