The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
D rosophila : The Genetics of Innate Immune Recognition and Response
Abstract
▪ Abstract Because of the evolutionary conservation of innate mechanisms of host defense, Drosophila has emerged as an ideal animal in which to study the genetic control of immune recognition and responses. The discovery that the Toll pathway is required for defense against fungal infection in Drosophila was pivotal in studies of both mammalian and Drosophila immunity. Subsequent genetic screens in Drosophila to isolate additional mutants unable to induce humoral responses to infection have identified and ordered the function of components of two signaling cascades, the Toll and Imd pathways, that activate responses to infection. Drosophila blood cells also contribute to host defense through phagocytosis and signaling, and may carry out a form of self-nonself recognition that is independent of microbial pattern recognition. Recent work suggests that Drosophila will be a useful model for dissecting virulence mechanisms of several medically important pathogens.
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Citations
Cites
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836
Self-citationBinding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
Weber, A. N. R., Tauszig-Delamasure, S., Hoffmann, J. A., Lelièvre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J.-L., & Gay, N. J. (2003) · Nature Immunology · doi:10.1038/ni955 · Cited by 469
Schneider, D. S., Hudson, K. L., Lin, T. Y., & Anderson, K. V. (1991) · Genes & Development · doi:10.1101/gad.5.5.797 · Cited by 325
Self-citationJNK Signaling Pathway Is Required for Efficient Wound Healing in Drosophila
Rämet, M., Lanot, R., Zachary, D., & Manfruelli, P. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0502 · Cited by 313
Cited by
The Host Defense of Drosophila melanogaster
Lemaitre, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,324
The proPO-system: pros and cons for its role in invertebrate immunity
Cerenius, L., Lee, B. L., & Söderhäll, K. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.02.009 · Cited by 1,246
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
Kocks, C., Cho, J. H., Nehme, N., Ulvila, J., Pearson, A. M., Meister, M., Strom, C., Conto, S. L., Hetru, C., Stuart, L. M., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.034 · Cited by 422
Nimrod, a Putative Phagocytosis Receptor with EGF Repeats in Drosophila Plasmatocytes
Kurucz, É., Márkus, R., Zsámboki, J., Folkl-Medzihradszky, K., Darula, Z., Vilmos, P., Udvardy, A., Krausz, I., Lukacsovich, T., Gateff, E., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.02.041 · Cited by 347
An innate immune response of blood cells to tumors and tissue damage in Drosophila
Pastor-Pareja, J. C., Wu, M., & Xu, T. (2008) · Disease Models & Mechanisms · doi:10.1242/dmm.000950 · Cited by 309
Metadata
- Authors
- Brennan, C. A., & Anderson, K. V.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2004-04-01
- Volume
- 22
- Issue
- 1
- Pages
- 457-483
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2156739718
- Cited by
- 356
- References
- 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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