The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
I mmunity to T uberculosis
Abstract
▪ Abstract Only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and over 85% of them develop the disease exclusively in the lungs. Human immunodeficiency virus (HIV)-infected humans, in contrast, can develop systemic disease that is more quickly lethal. This is in keeping with other evidence showing that susceptible humans generate some level of Th1 immunity to Mycobacterium tuberculosis (Mtb) infection. Tuberculosis in mice is also exclusively a lung disease that is progressive and lethal, in spite of the generation of Th1-mediated immunity. Thus mouse tuberculosis is a model of tuberculosis in susceptible humans, as is tuberculosis in guinea pigs and rabbits. Inability to resolve infection and prevent disease may not be a consequence of the generation of an inadequate number of Th1 cells but of an intrinsic deficiency in macrophage function that prevents these cells from expressing immunity. If this proves to be true, vaccinating susceptible humans against tuberculosis will be a difficult task.
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Cites
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An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
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Disseminated tuberculosis in interferon gamma gene-disrupted mice.
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Self-citationGenetic Dissection of Immunity to Mycobacteria: The Human Model
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THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO
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Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
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Mycobacterium tuberculosis: here today, and here tomorrow
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How can immunology contribute to the control of tuberculosis?
Kaufmann, S. H. E. (2001) · Nature Reviews Immunology · doi:10.1038/35095558 · Cited by 729
Cited by
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571
Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis
Vandal, O. H., Pierini, L. M., Schnappinger, D., Nathan, C. F., & Ehrt, S. (2008) · Nature Medicine · doi:10.1038/nm.1795 · Cited by 368
The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
Cooper, A. M., & Khader, S. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00702.x · Cited by 353
Metadata
- Authors
- North, R. J., & Jung, Y.-J.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2004-04-01
- Volume
- 22
- Issue
- 1
- Pages
- 599-623
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2100531445
- Cited by
- 677
- References
- 72
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
