Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection
Open accessAbstract
Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two multifunctional inflammatory monocyte-macrophage and DC populations that coexpressed both IL-1 species at the single-cell level in lungs of Mtb-infected mice. Moreover, we demonstrated that interferons (IFNs) played important roles in regulating IL-1 production by these cells in vivo. Type I interferons inhibited IL-1 production by both subsets whereas CD4(+) T cell-derived IFN-γ selectively suppressed monocyte-macrophages. These data provide a cellular basis for both the anti-inflammatory effects of IFNs and probacterial functions of type I IFNs during Mtb infection and reveal differential regulation of IL-1 production by distinct cell populations as an additional layer of complexity in the activity of IL-1 in vivo.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-1β is massively induced upon infection of macrophages with M. tuberculosis and plays important roles in anti-mycobacterial immune defenses because knockout mice are more susceptible to this infection.
“IL-1β is massively induced upon infection of macrophages with M. tuberculosis, and it appears to play important roles in anti-mycobacterial immune defenses because knockout mice are more susceptible to this infection (98)”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898 · see citing works
TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection
Serbina, N. V., Salazar‐Mather, T. P., Biron, C. A., Kuziel, W. A., & Pamer, E. G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,174 · see citing works
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144 · see citing works
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924 · see citing works
Type I interferon: friend or foe?
Trinchieri, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101664 · Cited by 838 · see citing works
North, R. J., & Jung, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104635 · Cited by 677 · see citing works
Cheong, C., Matos, I., Choi, J.-H., Dandamudi, D., Shrestha, E., Longhi, M. P., Jeffrey, K., Anthony, R. M., Kluger, C., Nchinda, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.039 · Cited by 647 · see citing works
Manca, C., Tsenova, L., Bergtold, A., Freeman, S. L., Tovey, M. G., Musser, J. M., Barry, C. E., Freedman, V. H., & Kaplan, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091096998 · Cited by 590 · see citing works
Wolf, A. J., Linas, B. S., Trevejo-Nuñez, G., Kincaid, E., Tamura, T., Takatsu, K., & Ernst, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2509 · Cited by 558 · see citing works
Unravelling mononuclear phagocyte heterogeneity
Geissmann, F., Gordon, S., Hume, D. A., Mowat, A. M., & Randolph, G. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2784 · Cited by 529 · see citing works
Self-citationThe role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O’Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472 · see citing works
Mayer-Barber, K. D., Barber, D. L., Shenderov, K., White, S., Wilson, M. S., Cheever, A. W., Kugler, D. G., Hieny, S. E., Caspar, P., Núñez, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904189 · Cited by 472 · see citing works
Self-citationLowes, M. A., Chamian, F. N., Abello, M. V., Fuentes‐Duculan, J., Lin, S., Nussbaum, R., Novitskaya, I., Carbonaro, H., Cardinale, I. R., Kikuchi, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509736102 · Cited by 458 · see citing works
Lin, K. L., Suzuki, Y. A., Nakano, H., Ramsburg, E. A., & Gunn, M. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2562 · Cited by 441 · see citing works
Stanley, S. A., Johndrow, J. E., Manzanillo, P. S., & Cox, J. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3143 · Cited by 439 · see citing works
Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii
Dunay, I. R., DaMatta, R. A., Fux, B., Presti, R. M., Greco, S., Colonna, M., & Sibley, L. D. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.019 · Cited by 433 · see citing works
IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins
Hu, X., Paik, P. K., Chen, J., Yarilina, A., Kockeritz, L. K., Lu, T. T., Woodgett, J. R., & Ivashkiv, L. B. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.014 · Cited by 407 · see citing works
Fremond, C., Togbe, D., Doz, E., Rose, S., Vasseur, V., Maillet, I., Jacobs, M., Ryffel, B., & Quesniaux, V. F. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1178 · Cited by 339 · see citing works
Caspase 1–independent activation of interleukin‐1β in neutrophil‐predominant inflammation
Gumá, M., Ronacher, L., Liu‐Bryan, R., Takai, S., Karin, M., & Corr, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24959 · Cited by 305 · see citing works
Role of innate cytokines in mycobacterial infection
Cooper, A. M., Mayer-Barber, K. D., & Sher, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.13 · Cited by 301 · see citing works
Self-citationJoosten, L. A. B., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M. A., Sparrer, H., Pham, C. T. N., van der Meer, J. W. M., Dinarello, C. A., & van den Berg, W. B. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25006 · Cited by 296 · see citing works
Manca, C., Tsenova, L., Freeman, S. L., Barczak, A. K., Tovey, M. G., Murray, P. J., Barry, C. E., & Kaplan, G. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.694 · Cited by 295 · see citing works
Antonelli, L. R. D. V., Rothfuchs, A. G., Gonçalves, R., Roffê, E., Cheever, A. W., Báfica, A. L. B., Salazar, A. Μ., Feng, C. G., & Sher, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40817 · Cited by 292 · see citing works
Self-citationIn Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice
Turner, J., Juarrero, M. G., Ellis, D. L., Basaraba, R. J., Kipnis, A., Orme, I. M., & Cooper, A. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6343 · Cited by 277 · see citing works
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., & Tschopp, J. (2009) · Nature · doi:10.1038/nature08100 · Cited by 250 · see citing works
Novikov, A., Cardone, M., Thompson, R. W., Shenderov, K., Kirschman, K. D., Mayer-Barber, K. D., Myers, T. G., Rabin, R. L., Trinchieri, G., Sher, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100926 · Cited by 238 · see citing works
Self-citationRedford, P. S., Boonstra, A., Read, S., Pitt, J. M., Graham, C. M., Stavropoulos, E., Bancroft, G. J., & O’Garra, A. (2010) · European Journal of Immunology · doi:10.1002/eji.201040433 · Cited by 233 · see citing works
Chang, E. Y., Guo, B., Doyle, S. E., & Cheng, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6705 · Cited by 228 · see citing works
Induction of IFN-αβ enables Listeria monocytogenes to suppress macrophage activation by IFN-γ
Rayamajhi, M., Humann, J., Penheiter, K. L., Andreasen, K., & Lenz, L. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091746 · Cited by 209 · see citing works
Tim3 binding to galectin-9 stimulates antimicrobial immunity
Jayaraman, P., Sada‐Ovalle, I., Beladi, S., Anderson, A. C., Dardalhon, V., Hotta, C., Kuchroo, V. K., & Behar, S. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100687 · Cited by 198 · see citing works
Trez, C. D., Magez, S., Akira, S., Ryffel, B., Carlier, Y., & Muraille, É. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000494 · Cited by 194 · see citing works
Division of labor between dendritic cell subsets of the lung
GeurtsvanKessel, C. H., & Lambrecht, B. N. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.39 · Cited by 188 · see citing works
McElvania, E., Allen, I. C., Hulseberg, P. D., Sullivan, J. T., McCann, J. R., Sándor, M., Braunstein, M., & Ting, J. P. ‐. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012320 · Cited by 155 · see citing works
Induction of circulating IL-1 receptor antagonist by IFN treatment
Tilg, H., Mier, J. W., Vogel, W., Aulitzky, W. E., Wiedermann, C. J., Vannier, E. G., Huber, C. H., & Dinarello, C. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.10.4687 · Cited by 136 · see citing works
Thacker, S. G., Berthier, C. C., Mattinzoli, D., Rastaldi, M. P., Kretzler, M., & Kaplan, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001782 · Cited by 134 · see citing works
Origins and tissue‐context‐dependent fates of blood monocytes
Varol, C., Yona, S., & Jung, S. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.90 · Cited by 132 · see citing works
Garlanda, C., Liberto, D. D., Vecchi, A., Manna, M. P. L., Buracchi, C., Caccamo, N., Salerno, A., Dieli, F., & Mantovani, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3119 · Cited by 119 · see citing works
Sköld, M., & Behar, S. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6349 · Cited by 102 · see citing works
Masters, S. L., Mielke, L. A., Cornish, A. L., Sutton, C. E., O’Donnell, J. A., Cengia, L. H., Roberts, A. W., Wicks, I. P., Mills, K. H. G., & Croker, B. A. (2010) · EMBO Reports · doi:10.1038/embor.2010.93 · Cited by 76 · see citing works
Guler, R., Parihar, S. P., Spohn, G., Johansen, P., Brombacher, F., & Bachmann, M. F. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.10.045 · Cited by 68 · see citing works
Rayamajhi, M., Humann, J., Kearney, S. J., Hill, K. K., & Lenz, L. L. (2010) · Virulence · doi:10.4161/viru.1.5.12787 · Cited by 66 · see citing works
Saunders, B. M., Briscoe, H., & Britton, W. J. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02518.x · Cited by 62 · see citing works
How interleukin‐1β induces gouty arthritis
Dinarello, C. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27663 · Cited by 59 · see citing works
Hu, X., Ho, H. H., Lou, O., Hidaka, C., & Ivashkiv, L. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.131 · Cited by 52 · see citing works
NALP3 is not necessary for early protection against experimental tuberculosis
Walter, K., Hölscher, C., Tschopp, J., & Ehlers, S. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.015 · Cited by 47 · see citing works
Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.
Schindler, R., Ghezzi, P., & Dinarello, C. (1989) · PubMed · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500 · see citing works
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,311 · see citing works
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780 · see citing works
Self-citationThe Immune Response in Tuberculosis
O’Garra, A., Redford, P. S., McNab, F. W., Bloom, C. I., Wilkinson, R. J., & Berry, M. P. R. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095939 · Cited by 1,351 · see citing works
IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,084 · see citing works
Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
Regulation of inflammasome signaling
Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 927 · see citing works
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812 · see citing works
Self-citationHost-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Mayer-Barber, K. D., Andrade, B. B., Oland, S. D., Amaral, E. P., Barber, D. L., Gonzales, J., Derrick, S. C., Shi, R., Kumar, N. P., Wei, W., et al. (2014) · Nature · doi:10.1038/nature13489 · Cited by 757 · see citing works
Self-citationTBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Pilli, M., Arko-Mensah, J., Ponpuak, M., Roberts, E., Master, S., Mandell, M. A., Dupont, N., Ornatowski, W., Jiang, S., Bradfute, S. B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.015 · Cited by 655 · see citing works
Watson, R. O., Bell, S. L., MacDuff, D. A., Kimmey, J. M., Diner, E. J., Olivas, J., Vance, R. E., Stallings, C. L., Virgin, H. W., & Cox, J. S. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.004 · Cited by 645 · see citing works
The immunological life cycle of tuberculosis
Ernst, J. (2012) · Nature reviews. Immunology · doi:10.1038/nri3259 · Cited by 570 · see citing works
Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571 · see citing works
Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L., Mayer-Barber, K. D., Andrade, B. B., & Sher, A. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181776 · Cited by 464 · see citing works
Self-citationAutophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
Castillo, E. F., Dekonenko, A., Arko‐Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., Delgado-Vargas, M., Timmins, G. S., Bhattacharya, D., Yang, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210500109 · Cited by 451 · see citing works
Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.003 · Cited by 401 · see citing works
Cytokines and Chemokines inMycobacterium tuberculosisInfection
Domingo-Gonzalez, R., Prince, O. A., Cooper, A. M., & Khader, S. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0018-2016 · Cited by 413 · see citing works
T cells and adaptive immunity to Mycobacterium tuberculosis in humans
Jasenosky, L. D., Scriba, T. J., Hanekom, W. A., & Goldfeld, A. E. (2015) · Immunological Reviews · doi:10.1111/imr.12274 · Cited by 363 · see citing works
Sakai, S., Kauffman, K. D., Sallin, M. A., Sharpe, A. H., Young, H. A., Ganusov, V. V., & Barber, D. L. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005667 · Cited by 349 · see citing works
Self-citationSTING pathway agonism as a cancer therapeutic
Flood, B. A., Higgs, E. F., Li, S., Luke, J. J., & Gajewski, T. F. (2019) · Immunological Reviews · doi:10.1111/imr.12765 · Cited by 338 · see citing works
Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis
Cavalcanti, Y. V. N., de Castro, M. C. A. B., Neves, J. K. D. A. L., Ferraz, J. C., & Pereira, V. R. A. (2012) · Pulmonary Medicine · doi:10.1155/2012/745483 · Cited by 323 · see citing works
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 321 · see citing works
Inflammatory dendritic cells in mice and humans
Segura, É., & Amigorena, S. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.06.001 · Cited by 301 · see citing works
Type I interferons in tuberculosis: Foe and occasionally friend
Moreira-Teixeira, L., Mayer-Barber, K. D., Sher, A., & O’Garra, A. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180325 · Cited by 273 · see citing works
Self-citationWang, Y., Ning, X., Gao, P., Wu, S., Sha, M., Lv, M., Zhou, X., Gao, J., Fang, R., Meng, G., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.011 · Cited by 275 · see citing works
Guilliams, M., Lambrecht, B. N., & Hammad, H. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.14 · Cited by 261 · see citing works
The balance between protective and pathogenic immune responses in the TB-infected lung
Orme, I. M., Robinson, R., & Cooper, A. M. (2014) · Nature Immunology · doi:10.1038/ni.3048 · Cited by 286 · see citing works
Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease
Bottini, N., & Peterson, E. J. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120249 · Cited by 234 · see citing works
Moreira-Teixeira, L., Stimpson, P., Stavropoulos, E., Hadebe, S., Chakravarty, P., Ιωάννου, Μ., Aramburu, I. V., Herbert, E., Priestnall, S. L., Suárez‐Bonnet, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19412-6 · Cited by 232 · see citing works
Dorhoi, A., Yeremeev, V., Nouailles, G., Weiner, J. M., Jörg, S., Heinemann, E., Oberbeck‐Müller, D., Knaul, J. K., Vogelzang, A., Reece, S. T., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344219 · Cited by 228 · see citing works
Jayaraman, P., Sada‐Ovalle, I., Nishimura, T., Anderson, A. C., Kuchroo, V. K., Remold, H. G., & Behar, S. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202688 · Cited by 217 · see citing works
Mayer-Barber, K. D., & Yan, B. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.25 · Cited by 206 · see citing works
Self-citationThe Innate Immune Response to Mycobacterium tuberculosis Infection
Ravesloot-Chávez, M. M., Dis, E. S. V., & Stanley, S. A. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-010426 · Cited by 208 · see citing works
Post-translational regulation of inflammasomes
Yang, J., Liu, Z., & Xiao, T. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.29 · Cited by 201 · see citing works
Critical role of AIM2 in Mycobacterium tuberculosis infection
Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M., & Takeda, K. (2012) · International Immunology · doi:10.1093/intimm/dxs062 · Cited by 202 · see citing works
McNab, F. W., Ewbank, J., Howes, A., Moreira-Teixeira, L., Մարտիրոսյան, Ա., Ghilardi, N., Saraiva, M., & O’Garra, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401088 · Cited by 198 · see citing works
Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections
Davidson, S., Maini, M. K., & Wack, A. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0227 · Cited by 197 · see citing works
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
Ji, D. X., Yamashiro, L. H., Chen, K. J., Mukaida, N., Kramnik, I., Darwin, K. H., & Vance, R. E. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0578-3 · Cited by 180 · see citing works
Singh, T. P., Zhang, H. H., Borek, I., Wolf, P., Hedrick, M. N., SINGH, S. P., Kelsall, B. L., Clausen, B. E., & Farber, J. M. (2016) · Nature Communications · doi:10.1038/ncomms13581 · Cited by 181 · see citing works
Tuberculosis and the art of macrophage manipulation
Upadhyay, S., Mittal, E., & Philips, J. A. (2018) · Pathogens and Disease · doi:10.1093/femspd/fty037 · Cited by 178 · see citing works
The Regulation of IL-10 Expression
Gabryšová, L., Howes, A., Saraiva, M., & O’Garra, A. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-43492-5_8 · Cited by 181 · see citing works
Ali, S., Mann‐Nüttel, R., Schulze, A., Richter, L., Alferink, J., & Scheu, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00778 · Cited by 176 · see citing works
Innate and Adaptive Cellular Immune Responses to Mycobacterium tuberculosis InfectionPreprint
Mayer-Barber, K. D., & Barber, D. L. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018424 · Cited by 175 · see citing works
Self-citationCaspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
Casson, C. N., Copenhaver, A. M., Zwack, E. E., Nguyen, H. T., Strowig, T., Javdan, B., Bradley, W. P., Fung, T. C., Flavell, R. A., Brodsky, I. E., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003400 · Cited by 178 · see citing works
Dynamic Roles of Type I and Type II IFNs in Early Infection with Mycobacterium tuberculosis
Desvignes, L., Wolf, A. J., & Ernst, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200255 · Cited by 172 · see citing works
Gong, W., & Wu, X. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.745592 · Cited by 176 · see citing works
Beyond macrophages: the diversity of mononuclear cells in tuberculosis
Srivastava, S., Ernst, J., & Desvignes, L. (2014) · Immunological Reviews · doi:10.1111/imr.12217 · Cited by 167 · see citing works
Pitt, J. M., Stavropoulos, E., Redford, P. S., Beebe, A. M., Bancroft, G. J., Young, D. B., & O’Garra, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201061 · Cited by 165 · see citing works
Regulation of Interleukin-10 Expression
Rutz, S., & Ouyang, W. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_5 · Cited by 166 · see citing works
Tumor necrosis factor alpha in mycobacterial infection
Dorhoi, A., & Kaufmann, S. H. E. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.003 · Cited by 164 · see citing works
The human immune response to tuberculosis and its treatment: a view from the blood
Cliff, J. M., Kaufmann, S. H. E., McShane, H., van Helden, P. D., & O’Garra, A. (2015) · Immunological Reviews · doi:10.1111/imr.12269 · Cited by 158 · see citing works
Immune cell interactions in tuberculosis
Flynn, J. L., & Chan, J. (2022) · Cell · doi:10.1016/j.cell.2022.10.025 · Cited by 157 · see citing works
Cytokine and lipid mediator networks in tuberculosis
Mayer-Barber, K. D., & Sher, A. (2015) · Immunological Reviews · doi:10.1111/imr.12249 · Cited by 155 · see citing works
Self-citationHow Inflammasomes Inform Adaptive Immunity
Evavold, C. L., & Kagan, J. C. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.09.019 · Cited by 148 · see citing works
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
Kotov, D. I., Lee, O. V., Fattinger, S. A., Langner, C. A., Guillen, J. V., Peters, J. M., Moon, A., Burd, E. M., Witt, K. C., Stetson, D. B., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.002 · Cited by 146 · see citing works
Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis
Dorhoi, A., & Kaufmann, S. H. E. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0531-3 · Cited by 150 · see citing works
Redford, P. S., Mayer-Barber, K. D., McNab, F. W., Stavropoulos, E., Wack, A., Sher, A., & O’Garra, A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit424 · Cited by 134 · see citing works
Self-citationCharmoy, M., Hurrell, B. P., Romano, A., Lee, S. H., Ribeiro-Gomes, F. L., Riteau, N., Mayer-Barber, K. D., Tacchini‐Cottier, F., & Sacks, D. L. (2015) · European Journal of Immunology · doi:10.1002/eji.201546015 · Cited by 135 · see citing works
Self-citationPlumlee, C. R., Duffy, F. J., Gern, B. H., Delahaye, J. L., Cohen, S. B., Stoltzfus, C. R., Rustad, T. R., Hansen, S. G., Axthelm, M. K., Picker, L. J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.10.003 · Cited by 135 · see citing works
Type I interferon decreases macrophage energy metabolism during mycobacterial infection
Olson, G. S., Murray, T. A., Jahn, A. N., Mai, D., Diercks, A. H., Gold, E. S., & Aderem, A. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109195 · Cited by 130 · see citing works
Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design
Ernst, J. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.004 · Cited by 131 · see citing works
Caffrey, A. K., Lehmann, M. M., Zickovich, J. M., Espinosa, V., Shepardson, K. M., Watschke, C. P., Hilmer, K. M., Thammahong, A., Barker, B. M., Rivera, A., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004625 · Cited by 132 · see citing works
Inflammation in tuberculosis: interactions, imbalances and interventions
Kaufmann, S. H. E., & Dorhoi, A. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.005 · Cited by 135 · see citing works
Hossain, M. M., & Norazmi, M. N. (2013) · BioMed Research International · doi:10.1155/2013/179174 · Cited by 135 · see citing works
IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo
Barry, K. C., Fontana, M. F., Portman, J. L., Dugan, A. S., & Vance, R. E. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300100 · Cited by 125 · see citing works
Macrophage immunoregulatory pathways in tuberculosis
Rajaram, M. V. S., Ni, B., Dodd, C. E., & Schlesinger, L. S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.010 · Cited by 125 · see citing works
Shah, S., Bohsali, A., Ahlbrand, S. E., Srinivasan, L., Rathinam, V. A. K., Vogel, S. N., Fitzgerald, K. A., Sutterwala, F. S., & Briken, V. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301331 · Cited by 123 · see citing works
Host-Directed Therapies for Tuberculosis: Figure 1.Preprint
Tobin, D. M. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a021196 · Cited by 119 · see citing works
Type I interferon signaling mediates Mycobacterium tuberculosis –induced macrophage death
Zhang, L., Jiang, X., Pfau, D. J., Ling, Y., & Nathan, C. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200887 · Cited by 113 · see citing works
Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo
Repasy, T., Lee, J., Marino, S., Martínez, N., Kirschner, D. E., Hendricks, G. M., Baker, S. P., Wilson, A. A., Kotton, D. N., & Kornfeld, H. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003190 · Cited by 117 · see citing works
Kumar, N. P., Sridhar, R., Banurekha, V. V., Jawahar, M. S., Fay, M. P., Nutman, T. B., & Babu, S. (2013) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201305-112oc · Cited by 120 · see citing works
T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
Moreira-Teixeira, L., Redford, P. S., Stavropoulos, E., Ghilardi, N., Maynard, C. L., Weaver, C. T., do Rosário, A. P. F., Wu, X., Langhorne, J., & O’Garra, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601340 · Cited by 120 · see citing works
Amaral, E. P., Riteau, N., Moayeri, M., Maier, N. K., Mayer-Barber, K. D., Pereira, R. M., Lage, S. L., Kübler, A., Bishai, W. R., Lima, M. R. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01427 · Cited by 119 · see citing works
Self-citationAmaral, E. P., Conceição, E. L., Costa, D. L., Rocha, M. S., Marinho, J. M., Cordeiro‐Santos, M., Lima, M. R. D., Barbosa, T., Sher, A., & Andrade, B. B. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0872-7 · Cited by 118 · see citing works
Self-citationType I interferons in bacterial infections: A balancing act
Kovarik, P., Castiglia, V., Ivin, M., & Ebner, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00652 · Cited by 117 · see citing works
Donovan, M. L., Schultz, T. E., Duke, T. J., & Blumenthal, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01633 · Cited by 114 · see citing works
Fejér, G., Wegner, M., Győry, I., Cohen, I., Engelhard, P., Voronov, E., Manke, T., Ruzsics, Z., Dölken, L., da Costa, O. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302877110 · Cited by 112 · see citing works
Host defense mechanisms against Mycobacterium tuberculosis
Chai, Q., Lü, Z., & Liu, C. H. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03353-5 · Cited by 118 · see citing works
Towards efficient immunotherapy for bacterial infection
McCulloch, T. R., Wells, T. J., & Souza-Fonseca-Guimarães, F. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.05.005 · Cited by 116 · see citing works
Oh, J. Y., Ko, J. H., Lee, H. J., Yu, J. M., Choi, H., Kim, M. K., Wee, W. R., & Prockop, D. J. (2014) · Stem Cells · doi:10.1002/stem.1608 · Cited by 125 · see citing works
Investigating the Causes for Decreased Levels of Glutathione in Individuals with Type II Diabetes
Lagman, M., Ly, J., Saing, T., Singh, M., Tudela, E. V., Morris, D., Chi, P.-T., Ochoa, C., Sathananthan, A., & Venketaraman, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118436 · Cited by 108 · see citing works
Autophagy as an immune effector against tuberculosis
Bradfute, S. B., Castillo, E. F., Arko‐Mensah, J., Chauhan, S., Jiang, S., Mandell, M. A., & Deretic, V. P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.05.003 · Cited by 103 · see citing works
de, M. M., Kumar, R., Rivera, F. D. L., Amante, F. H., Sheel, M., Faleiro, R. J., Bunn, P. T., Best, S. E., Beattie, L., Ng, S. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.015 · Cited by 101 · see citing works
GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection
Amaral, E. P., Foreman, T. W., Namasivayam, S., Hilligan, K. L., Kauffman, K. D., Bomfim, C. C. B., Costa, D. L., Barreto‐Duarte, B., Rocha, C. A. G., Santana, M. F., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220504 · Cited by 105 · see citing works
Self-citationChronic Bystander Infections and Immunity to Unrelated Antigens
Stelekati, E., & Wherry, E. J. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.001 · Cited by 103 · see citing works
Autophagy in TuberculosisPreprint
Deretic, V. P. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018481 · Cited by 100 · see citing works
Malireddi, R. K. S., & Kanneganti, T. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00077 · Cited by 99 · see citing works
Paolo, N. C. D., Shafiani, S., Day, T., Papayannopoulou, T., Russell, D. W., Iwakura, Y., Sherman, D. R., Urdahl, K. B., & Shayakhmetov, D. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.016 · Cited by 94 · see citing works
Moreira-Teixeira, L., Sousa, J., McNab, F. W., Torrado, E., Cardoso, F., Machado, H., Castro, F., Cardoso, V., Gaifem, J., Wu, X., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600584 · Cited by 99 · see citing works
Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Damböck, U., Kröger, A., Weiss, S., Knapp, S., Jamieson, A. M., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.02.003 · Cited by 96 · see citing works
Innate immunity and tolerance toward mitochondria
Rongvaux, A. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.10.007 · Cited by 110 · see citing works
Amaral, E. P., Ribeiro, S. C. M., Lanes, V. R., Almeida, F. M., de Andrade, M. R. M., Bomfim, C. C. B., de Salles, É. M., Bortoluci, K. R., Coutinho‐Silva, R., Hirata, M. H., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004188 · Cited by 97 · see citing works
McNab, F. W., Ewbank, J., Rajsbaum, R., Stavropoulos, E., Մարտիրոսյան, Ա., Redford, P. S., Wu, X., Graham, C. M., Saraiva, M., Tsichlis, P. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300146 · Cited by 94 · see citing works
The Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis
Amaral, E. P., Vinhaes, C. L., Oliveira-de-Souza, D., Nogueira, B. M. F., Akrami, K., & Andrade, B. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8124 · Cited by 97 · see citing works
Self-citationSusceptibility to chronic inflammation: an update
Nasef, N. A., Mehta, S. Y., & Ferguson, L. R. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1914-5 · Cited by 95 · see citing works
The role of type I interferons in intestinal infection, homeostasis, and inflammation
Cho, H., & Kelsall, B. L. (2014) · Immunological Reviews · doi:10.1111/imr.12195 · Cited by 91 · see citing works
Inflammasome activation and Th17 responses
Deng, J. P., Yu, X., & Wang, P. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2018.12.024 · Cited by 94 · see citing works
Shi, H., Zhang, J., Han, X., Li, H., Xie, M., Sun, Y., Liu, W., Ba, X., & Zeng, X. (2016) · International Journal of Cancer · doi:10.1002/ijc.30538 · Cited by 93 · see citing works
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship
Briken, V., Ahlbrand, S. E., & Shah, S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00062 · Cited by 92 · see citing works
Ivin, M., Dumigan, A., Vasconcelos, F., Ebner, F., Borroni, M., Kavirayani, A. M., Przybyszewska, K., Ingram, R. J., Lienenklaus, S., Kalinke, U., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006696 · Cited by 85 · see citing works
- Authors
- Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A.
- Affiliations
- National Institutes of Health (US)
- University of Oxford (GB)
- Corresponding author
- Mayer-Barber, Katrin D.
- Sher, Alan
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 35
- Issue
- 6
- Pages
- 1023-1034
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3246221
- OpenAlex
- W2023478821
- Cited by
- 418
- References
- 48
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 25 · 2023: 31 · 2022: 33 · 2021: 18 · 2020: 27 · 2019: 31 · 2018: 23 · 2017: 31 · 2016: 38 · 2015: 37 · 2014: 31 · 2013: 37 · 2012: 14
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AI999999)
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases (Y99 AI999999)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- Mycobacterium tuberculosis infection, interleukin-1 alpha, IL-1β, type I interferon, innate immunity, adaptive immunity, monocytes/macrophages, dendritic cells, host resistance, IL-1 signaling, single-cell analysis
- MeSH terms
- Animals, Antigens, Ly, Dendritic Cells, Humans, Interferons, Lung, Mice, Inbred C57BL, Mycobacterium tuberculosis, Phagocytes, Tuberculosis, Pulmonary, Signal Transduction, CD4-Positive T-Lymphocytes, Mice, Knockout, Myeloid Cells, CD11b Antigen, Mice, Interleukin-1alpha, Interleukin-1beta, Interleukin-12 Subunit p40
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
