The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Autoimmune and Inflammatory Mechanisms in Atherosclerosis
Abstract
The present review focuses on the concept that cellular and humoral immunity to the phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating mechanism in the earliest stages of atherosclerosis. Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60. Endothelial cells can also bind microbial or autologous HSP60 via Toll-like receptors, providing another possibility for targetting adaptive or innate immunological effector mechanisms.
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Citations
Cites
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Toll-like receptors and innate immunity
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Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
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Book ReviewAmbulatory Pediatric Care
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Cited by
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,317
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
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Macrophage Diversity and Polarization in Atherosclerosis: A Question of Balance
Mantovani, A., Garlanda, C., & Locati, M. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180497 · Cited by 426
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‘Ride on the ferrous wheel’ – The cycle of iron in macrophages in health and disease
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Metadata
- Authors
- Wick, G., Knoflach, M., & Xu, Q.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2004-04-01
- Volume
- 22
- Issue
- 1
- Pages
- 361-403
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2136347732
- Cited by
- 431
- References
- 190
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wick, G., Knoflach, M., & Xu, Q. (2004). Autoimmune and Inflammatory Mechanisms in Atherosclerosis. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.22.012703.104644
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
