The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation
Abstract
Long-term resistance to many infections depends on the innate ability of the immune system to coordinate the development of antigen-specific adaptive responses. Deficiencies in these events can result in increased susceptibility to pathogens, whereas an inability to regulate an appropriate response can lead to devastating pathological conditions. For over a decade, interleukin (IL)-12 has been recognized as the canonical cytokine that links innate and adaptive immunity, and with the discovery of IL-23 and IL-27 as cytokines related to IL-12, there has been a concerted effort to understand the relationship between these factors. The results emerging from these studies have provided fundamental new insights into the developmental pathways that promote the differentiation and function of CD4 + T helper cells and offer a dramatically altered perspective on the cause and prevention of autoimmune disease. In this review, we aim to highlight the discoveries that have led to our current understanding of the biology of IL-23 and IL-27 in the context of their role in resistance to infection, immune-mediated inflammation, and cancer.
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Cites
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Cited by
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Unravelling the pathogenesis of inflammatory bowel disease
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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
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IL-17 family cytokines and the expanding diversity of effector T cell lineages
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Reciprocal interactions of the intestinal microbiota and immune system
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Metadata
- Authors
- Kastelein, R. A., Hunter, C. A., & Cua, D. J.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2007-04-01
- Volume
- 25
- Issue
- 1
- Pages
- 221-242
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2128728003
- Cited by
- 763
- References
- 15
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation. https://app.cochat.ai/papers/10.1146/annurev.immunol.22.012703.104758
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- Kastelein, R. A., Hunter, C. A., & Cua, D. J. (2007). Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.22.012703.104758
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