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UNDERSTANDING PRESENTATION OF VIRAL ANTIGENS TO CD8+T CELLS IN VIVO: The Key to Rational Vaccine Design
Abstract
▪ Abstract CD8+T cells play a critical role in antiviral immunity by exerting direct antiviral activity against infected cells. Because of their ability to recognize all types of viral proteins, they offer the promise of providing broad immunity to viruses that evade humoral immunity by varying their surface proteins. Consequently, there is considerable interest in developing vaccines that elicit effective antiviral T CD8+responses. Generating optimal vaccines ultimately requires rational design based on detailed knowledge of how T CD8+are activated in vivo under natural circumstances. Here we review recent progress obtained largely by in vivo studies in mice to understand the mechanistic basis for activation of naive T CD8+in virus infections. These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design.
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Cited by
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Rudolph, M. G., Stanfield, R. L., & Wilson, I. A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115658 · Cited by 1,310
Yager, E. J., Ahmed, M., Lanzer, K., Randall, T. D., Woodland, D. L., & Blackman, M. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071140 · Cited by 490
Cross‐presentation: underlying mechanisms and role in immune surveillance
Rock, K. L., & Shen, L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00301.x · Cited by 451
The Alarmin Interleukin-33 Drives Protective Antiviral CD8 + T Cell Responses
Bonilla, W. V., Fröhlich, A., Senn, K., Kallert, S., Fernandez, M., Johnson, S., Kreutzfeldt, M., Hegazy, A. N., Schrick, C., Fallon, P. G., et al. (2012) · Science · doi:10.1126/science.1215418 · Cited by 417
Confronting Complexity: Real-World Immunodominance in Antiviral CD8+ T Cell Responses
Yewdell, J. W. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.005 · Cited by 364
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Metadata
- Authors
- Yewdell, J. W., & Haeryfar, S. M. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 651-682
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2149217412
- Cited by
- 215
- References
- 0
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yewdell, J. W., & Haeryfar, S. M. M. (2005). UNDERSTANDING PRESENTATION OF VIRAL ANTIGENS TO CD8+T CELLS IN VIVO: The Key to Rational Vaccine Design. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.23.021704.115702
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