Cited by 2,149Multiple Sclerosis Research StudiesT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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IMMUNOLOGY OF MULTIPLE SCLEROSIS

Sospedra, Mireia, Martin, Roland·2005·Annual Review of Immunology

DOI 10.1146/annurev.immunol.23.021704.115707

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Abstract

Multiple sclerosis (MS) develops in young adults with a complex predisposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these cells are probably also important players in the long-term evolution of the disease. Damage of the target tissue, the central nervous system, is, however, most likely mediated by other components of the immune system, such as antibodies, complement, CD8+ T cells, and factors produced by innate immune cells. Perturbations in immunomodulatory networks that include Th2 cells, regulatory CD4+ T cells, NK cells, and others may in part be responsible for the relapsing-remitting or chronic progressive nature of the disease. However, an important paradigmatic shift in the study of MS has occurred in the past decade. It is now clear that MS is not just a disease of the immune system, but that factors contributed by the central nervous system are equally important and must be considered in the future.

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Authors: Sospedra, M., & Martin, R.
Affiliations: National Institutes of Health (US)
Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1400;
ORCID: Sospedra, Mireia
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2005-04-01
Volume: 23
Issue: 1
Pages: 683-747
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.23.021704.115707
OpenAlex: W2113291839
Cited by: 2,149
References: 362
Citations by year: 2026: 27 · 2025: 43 · 2024: 62 · 2023: 64 · 2022: 69 · 2021: 72 · 2020: 78 · 2019: 84 · 2018: 71 · 2017: 110 · 2016: 107 · 2015: 149 · 2014: 133 · 2013: 144 · 2012: 120
FWCI: 19.06
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: multiple sclerosis, autoimmunity, CD4+ T cells, Th1 cells, Th2 cells, regulatory T cells, natural killer cells, CD8+ T cells, complement system, autoantibodies, innate immunity, viral triggers, genetic susceptibility, relapsing-remitting disease, chronic progressive disease, central nervous system, neuroimmune interactions
MeSH terms: Autoantibodies, Autoantigens, Central Nervous System, HLA Antigens, Humans, Immunity, Innate, Immunogenetics, Infections, Multiple Sclerosis, Myelin Proteins, T-Lymphocyte Subsets, Cytokines, Models, Immunological, Molecular Mimicry, Chemokines, Genomics

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