The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Biochemistry of Somatic Hypermutation
Abstract
Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced cytidine deaminase (AID) is the first of a complex series of proteins that introduce these point mutations into variable regions of the Ig genes. AID deaminates deoxycytidine residues in single-stranded DNA to deoxyuridines, which are then processed by DNA replication, base excision repair (BER), or mismatch repair (MMR). In germinal center B cells, MMR, BER, and other factors are diverted from their normal roles in preserving genomic integrity to increase diversity within the Ig locus. Both AID and these components of an emerging error-prone mutasome are regulated on many levels by complex mechanisms that are only beginning to be elucidated.
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Citations
Cites
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
Self-citationDNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
Zeng, X., Winter, D. B., Kasmer, C., Kraemer, K. H., Lehmann, A. R., & Gearhart, P. J. (2001) · Nature Immunology · doi:10.1038/88740 · Cited by 420 · cited 1×
“Studies with genetically defective mice and patients with the variant form of Xeroderma Pigmentosum, in whom Pol η is mutated, clearly demonstrate a critical role for Pol η in the introduction of transversion mutations at A:T bases that are the hallmark of the MMR-dependent second phase of SHM (109, 110) (Figures 2 an…”
BackgroundTranslesion synthesis: Y-family polymerases and the polymerase switch
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Cited by
Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317
“…Harb Perspect Biol 2013;5:a010363 Cite this article as Cold Spring Harb Perspect Biol 2013;5:a010363 13 (Rogozin et al. 2001; Zeng et al. 2001), this occurs during error-prone replication of undamaged DNA and generates various mutations, the ultimate source of genetic diversity (Peled et al. 2008).”
BackgroundInfluentialSelf-citationWalker, B. A., Wardell, C. P., Murison, A., Boyle, E. M., Begum, D. B., Dahir, N. M., Proszek, P. Z., Melchor, L., Pawlyn, C., Kaiser, M. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms7997 · Cited by 313
DNA replication fidelity and cancer
Preston, B. D., Albertson, T. M., & Herr, A. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.009 · Cited by 160
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126
The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity
Wolfe, A. D., Li, S., Goedderz, C., & Chen, X. S. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa027 · Cited by 28
Metadata
- Authors
- Peled, J. U., Kuang, F. L., Iglesias-Ussel, M. D., Roa, S., Kalis, S. L., Goodman, M. F., & Scharff, M. D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 481-511
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2098309323
- Cited by
- 462
- References
- 6
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peled, J. U., Kuang, F. L., Iglesias-Ussel, M. D., Roa, S., Kalis, S. L., Goodman, M. F., & Scharff, M. D. (2008). The Biochemistry of Somatic Hypermutation. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090236
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
