Cited by 163DNA Repair MechanismsCancer-related Molecular PathwaysGenetic factors in colorectal cancer

DNA replication fidelity and cancer

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Preston, Bradley D., Albertson, Tina M., Herr, Alan J.·2010·Seminars in Cancer Biology

Abstract

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

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Crossref · 10.1016/j.semcancer.2010.10.009

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  • Tumor genomes can become highly unstable as a result of impaired DNA damage repair or DNA proofreading functions, giving rise to spontaneous mutations throughout a cancer's lifespan.

    “Additionally, tumor genomes can become highly unstable as a result of impaired DNA damage repair or DNA proofreading functions, giving rise to spontaneous mutations throughout a cancer’s lifespan [98].”

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10 of the 251 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. [5]Nowell PC The clonal evolution of tumor cell populations Science 1976 194 23 8 959840
  2. [39]Arzimanoglou II Gilbert F Barber HR Microsatellite instability in human solid tumors Cancer 1998 82 1808 20 9587112
  3. [84]Treuting PM Albertson TM Preston BD Case series: acute tumor lysis syndrome in mutator mice with disseminated lymphoblastic lymphoma Toxicol Pathol 2010 38 476 85 20190201
  4. [127]Karthikeyan R Vonarx EJ Straffon AF Simon M Faye G Kunz BA Evidence from mutational specificity studies that yeast DNA polymerases δ and ε replicate different DNA strands at an intracellular replication fork J Mol Biol 2000 299 405 19 10860748
  5. [215]Flohr T Dai JC Buttner J Popanda O Hagmuller E Thielmann HW Detection of mutations in the DNA polymerase δ gene of human sporadic colorectal cancers and colon cancer cell lines Int J Cancer 1999 80 919 29 10074927

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Authors
Preston, B. D., Albertson, T. M., & Herr, A. J.
Affiliations
University of Washington (US)
Corresponding author
Preston, Bradley D.
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2010-10
Volume
20
Issue
5
Pages
281-293
ISSN
1044-579X (ISSN-L)
OpenAlex
W2056156376
Cited by
160
References
251
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 17 · 2012: 16
FWCI
1.16
Type
journal article
Language
en
Open access
Locations
  • Seminars in Cancer Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P01AG001751)
  • National Cancer Institute (P20CA103728, R01CA111582, P01CA077852, R01CA098243)
  • National Institute of Environmental Health Sciences (R01ES009927, P30ES007033)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
DNA replication fidelity, carcinogenesis, replication errors, mutation avoidance, positive selection, genome stability
MeSH terms
Animals, Chromosome Aberrations, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Mutation, Neoplasms, Gene Rearrangement, Point Mutation, Microsatellite Instability, DNA Mismatch Repair

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