DNA replication fidelity and cancer
Open accessAbstract
Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.
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Tumor genomes can become highly unstable as a result of impaired DNA damage repair or DNA proofreading functions, giving rise to spontaneous mutations throughout a cancer's lifespan.
“Additionally, tumor genomes can become highly unstable as a result of impaired DNA damage repair or DNA proofreading functions, giving rise to spontaneous mutations throughout a cancer’s lifespan [98].”
From KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance (2024) · cites this paper as [98]
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Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471 · see citing works
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 3× · see citing works
“[14].”
BackgroundGenome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,857 · see citing works
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456 · see citing works
Genomic instability — an evolving hallmark of cancer
Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397 · see citing works
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345 · see citing works
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271 · see citing works
Lynch, H. T., & de la Chapelle, A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra012242 · Cited by 2,201 · see citing works
Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050 · see citing works
Estimates of the worldwide incidence of 25 major cancers in 1990
Parkin, D. M., Pisani, P., & Ferlay, J. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990315)80:6 · Cited by 2,013 · see citing works
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995 · see citing works
Landon, M., Saam, J. R., Brown, K. L., Moyes, K., Evans, B. A., & WENSTRUP, R. J. (2015) · Oncology · doi:10.1159/000430097 · Cited by 1,943 · see citing works
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932 · see citing works
Mutation of a mutL Homolog in Hereditary Colon Cancer
Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822 · see citing works
Weinberg, R. A., & Weinberg, R. A. (2006) · W.W. Norton eBooks · doi:10.1201/9780203852569 · Cited by 1,806 · see citing works
A comprehensive catalogue of somatic mutations from a human cancer genome
Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696 · see citing works
Mechanisms and functions of DNA mismatch repair
Li, G. (2007) · Cell Research · doi:10.1038/cr.2007.115 · Cited by 1,479 · see citing works
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400 · see citing works
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,375 · see citing works
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,372 · see citing works
Hereditary and Familial Colon Cancer
Jasperson, K. W., Tuohy, T. M. F., Neklason, D. W., & Burt, R. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.054 · Cited by 1,314 · see citing works
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,134 · see citing works
Strand, M. K., Prolla, T. A., Liskay, R. M., & Petes, T. D. (1993) · Nature · doi:10.1038/365274a0 · Cited by 1,077 · see citing works
A small-cell lung cancer genome with complex signatures of tobacco exposure
Pleasance, E., Stephens, P. J., O’Meara, S., McBride, D. J., Meynert, A. M., Jones, D., Lin, M., Beare, D. M., Lau, K. W., Greenman, C., et al. (2009) · Nature · doi:10.1038/nature08629 · Cited by 1,067 · see citing works
Endogenous DNA damage in humans: a review of quantitative data
Bont, R. D. (2004) · Mutagenesis · doi:10.1093/mutage/geh025 · Cited by 1,065 · see citing works
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Parsons, R. E., Li, G., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. L. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,054 · see citing works
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,038 · see citing works
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003 · see citing works
Rules for Making Human Tumor Cells
Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951 · see citing works
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2005) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 906 · see citing works
Eukaryotic DNA mismatch repair
Kolodner, R. D., & Marsischky, G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80013-6 · Cited by 861 · see citing works
Lynch, H. T., Lynch, P. M., Lanspa, S. J., Snyder, C., Lynch, J. F., & Boland, C. R. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01230.x · Cited by 842 · see citing works
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807 · see citing works
de Wind, N., Dekker, M., Berns, A. J. M., Radman, M., & Riele, H. T. (1995) · Cell · doi:10.1016/0092-8674(95)90319-4 · Cited by 780 · see citing works
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753 · see citing works
Genetic instability and darwinian selection in tumours
Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Christoph Lengauer, C. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01661-x · Cited by 747 · see citing works
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
Miyaki, M., Konishi, M., Tanaka, K., Kikuchi‐Yanoshita, R., Muraoka, M., Yasuno, M., Igari, T., Koike, M., Chiba, M., & Mori, T. (1997) · Nature Genetics · doi:10.1038/ng1197-271 · Cited by 720 · see citing works
Repair of Endogenous DNA Damage
LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714 · see citing works
Michaels, M. L., & Miller, J. H. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.20.6321-6325.1992 · Cited by 693 · see citing works
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691 · see citing works
Genetic predisposition to colorectal cancer
de la Chapelle, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1453 · Cited by 660 · see citing works
Endonucleolytic Function of MutLα in Human Mismatch Repair
Kadyrov, F. A., Dzantiev, L., Constantin, N., & Modrich, P. L. (2006) · Cell · doi:10.1016/j.cell.2006.05.039 · Cited by 626 · see citing works
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581 · see citing works
Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis
Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A., Liskay, R. M., & Kunkel, T. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81323-9 · Cited by 577 · see citing works
Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication
Pursell, Z. F., Isoz, I., Lundström, E.-B., Johansson, E., & Kunkel, T. A. (2007) · Science · doi:10.1126/science.1144067 · Cited by 565 · see citing works
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 538 · see citing works
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
Acharya, S., Wilson, T., Gradia, S., Kane, M., Guerrette, S., Marsischky, G., Kolodner, R. D., & Fishel, R. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13629 · Cited by 534 · see citing works
Errors in DNA replication as a basis of malignant changes.
Loeb, L. A., Springgate, C. F., & Battula, N. (1974) · PubMed · Cited by 521 · see citing works
Division of labor at the eukaryotic replication fork.
McElhinny, S. A. N., Gordenin, D., Stith, C. M. W., Burgers, P., & Kunkel, T. (2008) · Molecules and Cells · doi:10.1016/j.molcel.2008.02.022 · Cited by 510 · see citing works
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
Lee, W., Jiang, Z., Liu, J., Haverty, P. M., Guan, Y., Stinson, J., Yue, P., Zhang, Y., Pant, K. P., Bhatt, D., et al. (2010) · Nature · doi:10.1038/nature09004 · Cited by 486 · see citing works
Maintenance of Genome Stability in Saccharomyces cerevisiae
Kolodner, R. D., Putnam, C. D., & Myung, K. (2002) · Science · doi:10.1126/science.1075277 · Cited by 464 · see citing works
DNA mismatch repair: Molecular mechanism, cancer, and ageing
Hsieh, P., & Yamane, K. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.012 · Cited by 463 · see citing works
Akiyama, Y., Sato, H., Yamada, T., Nagasaki, H., Tsuchiya, A., Abe, R., & Yuasa, Y. (1997) · PubMed · Cited by 463 · see citing works
The Biochemistry of Somatic Hypermutation
Peled, J. U., Kuang, F. L., Iglesias-Ussel, M. D., Roa, S., Kalis, S. L., Goodman, M. F., & Scharff, M. D. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090236 · Cited by 460 · see citing works
Biochemical Basis of DNA Replication Fidelity
Goodman, M. F., Creighton, S., Bloom, L. B., Petruska, J., & Kunkel, T. A. (1993) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239309086792 · Cited by 446 · cited 2× · see citing works
“1; reviewed in [53–71]).”
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
Kat, A. G., Thilly, W. G., Fang, W.-H., Longley, M. J., Li, G., & Modrich, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6424 · Cited by 443 · see citing works
Mutations Associated with HNPCC Predisposition — Update of ICG‐HNPCC/INSiGHT Mutation Database
Peltomäki, P., & Vasen, H. F. A. (2004) · Disease Markers · doi:10.1155/2004/305058 · Cited by 442 · see citing works
Repeat instability as the basis for human diseases and as a potential target for therapy
López Castel, A., Cleary, J. D., & Pearson, C. E. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2854 · Cited by 429 · see citing works
Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
Cleaver, J. E., Lam, E. T., & Revet, I. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2663 · Cited by 428 · cited 2× · see citing works
“[PubMed: 11927276] [24].”
BackgroundMutator phenotypes in human colorectal carcinoma cell lines.
Bhattacharyya, N. P., Skandalis, A., Ganesh, A. N., Groden, J. L., & Meuth, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6319 · Cited by 424 · see citing works
Imai, K., & Yamamoto, H. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm228 · Cited by 424 · see citing works
Mitelman Database (Chromosome Aberrations and Gene Fusions in Cancer)
Griffith, M., & Griffith, O. L. (2004) · Dictionary of Bioinformatics and Computational Biology · doi:10.1002/9780471650126.dob0996 · Cited by 420 · see citing works
Genschel, J., Littman, S. J., Drummond, J. T., & Modrich, P. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19895 · Cited by 419 · see citing works
Familial endometrial cancer in female carriers of MSH6 germline mutations
Wijnen, J., de Leeuw, W. J. F., Vasen, H. F. A., van der Klift, H. M., Møller, P., Stormorken, A. T., Meijers-Heijboer, H. E. J., Lindhout, D., Menko, F. H., Vossen, S., et al. (1999) · Nature Genetics · doi:10.1038/13773 · Cited by 415 · see citing works
Genetic Progression and the Waiting Time to Cancer
Beerenwinkel, N., Tibor Antal, A., Dingli, D., Traulsen, A., Kinzler, K. W., Velculescu, V. E., Vogelstein, B., & Nowak, M. A. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030225 · Cited by 409 · see citing works
DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint
Navas, T. A., Zhou, Z. Y., & Elledge, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90448-4 · Cited by 403 · see citing works
Duval, A., & Hamelin, R. (2002) · PubMed · Cited by 398 · see citing works
Mismatch repair and DNA damage signalling
Stojic, L., Brun, R., & Jiricny, J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.006 · Cited by 396 · see citing works
Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers
Baglietto, L., Lindor, N. M., Dowty, J. G., White, D. M., Wagner, A., Gómez-García, E. B., Vriends, A. H. J. T., Dutch Lynch Syndrome Study Group, Cartwright, N., Barnetson, R. A., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp473 · Cited by 375 · see citing works
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastPreprint
Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., & Araki, H. (2003) · Genes & Development · doi:10.1101/gad.1065903 · Cited by 372 · see citing works
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
Branch, P., Aquilina, G., Bignami, M., & Karran, P. (1993) · Nature · doi:10.1038/362652a0 · Cited by 361 · see citing works
Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J., Yao, X., Bronner, C. E., Zheng, B., Gordon, M. D., Reneker, J., Arnheim, N., et al. (1998) · Nature Genetics · doi:10.1038/ng0398-276 · Cited by 360 · see citing works
Human cancers express a mutator phenotype
Bielas, J. H., Loeb, K. R., Rubin, B. P., True, L. D., & Loeb, L. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607057103 · Cited by 354 · see citing works
Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
Minowa, O., Arai, T., Hirano, M., Monden, Y., Nakai, S., Fukuda, M., Itoh, M., Takano, H., Hippou, Y., Aburatani, H., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050404497 · Cited by 348 · see citing works
Tajiri, T., Maki, H., & Sekiguchi, M. (1995) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(94)00062-b · Cited by 340 · see citing works
BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATION
Cox, E. C. (1976) · Annual Review of Genetics · doi:10.1146/annurev.ge.10.120176.001031 · Cited by 340 · see citing works
Polymerase Dynamics at the Eukaryotic DNA Replication Fork
Burgers, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800062200 · Cited by 338 · see citing works
Germ-line msh6 mutations in colorectal cancer families.
Kolodner, R. D., Tytell, J. D., Schmeits, J. L., Kane, M., Gupta, R. D., Weger, J., Wahlberg, S., Fox, E. A., Peel, D. A., Ziogas, A., et al. (1999) · PubMed · Cited by 324 · see citing works
DNA polymerases and human disease
Loeb, L. A., & Monnat, R. J. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2345 · Cited by 316 · see citing works
DNA precursor metabolism and genomic stability
Mathews, C. K. (2006) · The FASEB Journal · doi:10.1096/fj.06-5730rev · Cited by 311 · see citing works
Chromosomal Translocations in Yeast Induced by Low Levels of DNA Polymerase
Lemoine, F. J., Degtyareva, N. P., Lobachev, K. S., & Petes, T. D. (2005) · Cell · doi:10.1016/j.cell.2004.12.039 · Cited by 306 · see citing works
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
Parsons, R. E., Li, G., Longley, M. J., Modrich, P. L., Liu, B., Berk, T., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1995) · Science · doi:10.1126/science.7632227 · Cited by 305 · see citing works
Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.
Schaaper, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80446-3 · Cited by 305 · see citing works
Tran, H. T., Keen, J. D., Kricker, M., Resnick, M. A., & Gordenin, D. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2859 · Cited by 302 · see citing works
Dividing the workload at a eukaryotic replication fork
Kunkel, T., & Burgers, P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.005 · Cited by 294 · see citing works
Xie, Y., Yang, H., Cunanan, C., Okamoto, K., Shibata, D., Pan, J., Barnes, D. E., Lindahl, T., McIlhatton, M., Fishel, R., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3834 · Cited by 291 · see citing works
ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts
Yoshioka, K.-I., Yoshioka, Y., & Hsieh, P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.023 · Cited by 288 · see citing works
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase
Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K. D., Ide, F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191086798 · Cited by 287 · see citing works
Shevelev, I. V., & Hübscher, U. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm804 · Cited by 284 · see citing works
Kesti, T., Flick, K. M., Keränen, S., Syväoja, J. E., & Wittenberg, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80361-5 · Cited by 276 · see citing works
Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.
Morrison, A., Bell, J. B., Kunkel, T. A., & Sugino, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9473 · Cited by 276 · see citing works
Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle–Control Genes
Wu, X., Gu, J. H., Grossman, H. B., Amos, C. I., Etzel, C. J., Huang, M., Zhang, Q. H., Millikan, R. E., Lerner, S., Dinney, C. P., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/500848 · Cited by 273 · see citing works
Pathway correcting DNA replication errors in Saccharomyces cerevisiae.
Morrison, A., Johnson, A. L., Johnston, L. H., & Sugino, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05790.x · Cited by 264 · see citing works
SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair
Miller, J. H. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.625 · Cited by 255 · see citing works
Taketo, M. M., & Edelmann, W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.049 · Cited by 252 · see citing works
Mutational Heterogeneity in Human Cancers: Origin and Consequences
Salk, J. J., Fox, E., & Loeb, L. A. (2009) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102113 · Cited by 249 · see citing works
Tlsty, T. D., Margolin, B. H., & Lum, K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9441 · Cited by 246 · see citing works
Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
Aparicio, O. M., Stout, A. M., & Bell, S. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9130 · Cited by 246 · see citing works
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Eshleman, J. R., Lang, E. Z., Bowerfind, G. K., Parsons, R. E., Vogelstein, B., Willson, J. K. V., Veigl, M. L., Sedwick, W. D., & Markowitz, S. D. (1995) · PubMed · Cited by 242 · see citing works
DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice
Albertson, T., Ogawa, M., Bugni, J. M., Hays, L. E., Chen, Y., Wang, Y., Treuting, P. M., Heddle, J. A., Goldsby, R. E., & Preston, B. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907147106 · Cited by 237 · see citing works
Self-citationOgg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Sakumi, K., Tominaga, Y., Furuichi, M., Xu, P., Tsuzuki, T., Sekiguchi, M., & Nakabeppu, Y. (2003) · PubMed · Cited by 237 · see citing works
Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion
Hicks, W. M., Kim, M., & Haber, J. E. (2010) · Science · doi:10.1126/science.1191125 · Cited by 233 · see citing works
Oxidative nucleotide damage: consequences and prevention
Sekiguchi, M., & Tsuzuki, T. (2002) · Oncogene · doi:10.1038/sj.onc.1206023 · Cited by 229 · see citing works
The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool
Colussi, C., Parlanti, E., Degan, P., Aquilina, G., Barnes, D., Macpherson, P., Karran, P., Crescenzi, M., Eugenia Dogliotti, Y., & Bignami, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00863-1 · Cited by 228 · see citing works
Simon, M., Giot, L., & Faye, G. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07751.x · Cited by 228 · see citing works
Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes
Clark, A., Valle, F., Drotschmann, K., Gary, R. K., & Kunkel, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000513200 · Cited by 227 · see citing works
Mechanisms of tolerance to DNA damaging therapeutic drugs
Karran, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.12.1931 · Cited by 226 · see citing works
Boulet, A., Simon, M., Faye, G., Bauer, G. A., & Burgers, P. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03580.x · Cited by 226 · see citing works
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
Kunz, B. A., Kohalmi, S. E., Kunkel, T. A., Mathews, C. K., McIntosh, E. M., & Reidy, J. A. (1994) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(94)90006-x · Cited by 225 · see citing works
Ni, T. T., Marsischky, G., & Kolodner, R. D. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80346-9 · Cited by 222 · see citing works
Cancers Exhibit a Mutator Phenotype: Clinical Implications
Loeb, L. A., Bielas, J. H., & Beckman, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5835 · Cited by 220 · see citing works
Meuth, M. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90090-6 · Cited by 219 · see citing works
de Wind, N., Dekker, M., Claij, N., Jansen, L. A. M., van Klink, Y., Radman, M., Riggins, G., van der Valk, M., Wout, K. V. '., & Riele, H. T. (1999) · Nature Genetics · doi:10.1038/15544 · Cited by 215 · see citing works
Evolving Views of DNA Replication (In)FidelityPreprint
Kunkel, T. A. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.027 · Cited by 206 · see citing works
Morrison, A., & Sugino, A. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00280418 · Cited by 205 · see citing works
Human DNA polymerase α: predicted functional domains and relationships with viral DNA polymerases
Wang, T. S., Wong, S. W., & Korn, D. A. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.1.2642867 · Cited by 203 · see citing works
Tran, H. T., Gordenin, D. A., & Resnick, M. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2000 · Cited by 201 · see citing works
Dua, R., Levy, D. L., & Campbell, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22283 · Cited by 200 · see citing works
Signalling cell cycle arrest and cell death through the MMR System
O’Brien, V., & Brown, R. E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi298 · Cited by 200 · see citing works
Amin, N. S., Nguyen, M.-N., Oh, S., & Kolodner, R. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5142-5155.2001 · Cited by 197 · see citing works
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
Lin, D. P., Wang, Y., Scherer, S. J., Clark, A. B., Yang, K., Avdievich, E., Jin, B., Werling, U., Parris, T., Kurihara, N., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2957 · Cited by 195 · see citing works
Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability
Johnson, R. E., Kovvali, G. K., Prakash, L., & Prakash, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7285 · Cited by 188 · see citing works
Masumoto, H., Sugino, A., & Araki, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2809-2817.2000 · Cited by 184 · see citing works
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
Duckett, D. R., Bronstein, S. M., Taya, Y., & Modrich, P. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12384 · Cited by 177 · see citing works
Evidence that Errors Made by DNA Polymerase α are Corrected by DNA Polymerase δ
Pavlov, Y. I., Frahm, C., McElhinny, S. A. N., Niimi, A., Suzuki, M., & Kunkel, T. A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.002 · Cited by 177 · see citing works
Apoptosis induced by overexpression of hMSH2 or hMLH1.
Zhang, H., Richards, B. T., Wilson, T., Lloyd, M., Cranston, A. N., Thorburn, A. M., Fishel, R. A., & Meuth, M. (1999) · PubMed · Cited by 176 · see citing works
Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice
Goldsby, R. E., Lawrence, N. A., Hays, L. E., Olmsted, E. A., Chen, X., Singh, M., & Preston, B. D. (2001) · Nature Medicine · doi:10.1038/88963 · Cited by 171 · see citing works
Self-citationAlani, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5604 · Cited by 167 · see citing works
High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading
Goldsby, R. E., Hays, L. E., Chen, X., Olmsted, E. A., Slayton, W. B., Spangrude, G. J., & Preston, B. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232340999 · Cited by 166 · see citing works
Self-citationSpontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
Reitmair, A. H., Redston, M. S., Cai, J. C., Chuang, T. C.-Y., Bjerknes, M., Cheng, H., Hay, K., Gallinger, S., Bapat, B. V., & Mak, T. W. (1996) · PubMed · Cited by 166 · see citing works
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
Yang, G., Scherer, S. J., Shell, S. S., Yang, K., Kim, M., Lipkin, M., Kucherlapati, R., Kolodner, R. D., & Edelmann, W. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.024 · Cited by 165 · see citing works
Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk
Smith, T. R., Levine, E. A., Freimanis, R. I., Akman, S. A., Allen, G. O., Hoang, K. N., Liu‐Mares, W., & Hu, J. J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn193 · Cited by 163 · see citing works
DNA polymerase proofreading: Multiple roles maintain genome stability
Reha-Krantz, L. J. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.06.012 · Cited by 162 · see citing works
Jin, Y. H., Obert, R., Burgers, P., Kunkel, T. A., Resnick, M. A., & Gordenin, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091095198 · Cited by 158 · see citing works
The kinetic and chemical mechanism of high-fidelity DNA polymerases
Johnson, K. A. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.01.006 · Cited by 156 · see citing works
Friedberg, E. C., & Meira, L. B. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.09.009 · Cited by 155 · see citing works
DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 gene
Sitney, K. C., Budd, M. E., & Campbell, J. L. (1989) · Cell · doi:10.1016/0092-8674(89)90582-5 · Cited by 154 · see citing works
Fishel, R. A. (2001) · PubMed · Cited by 154 · see citing works
Functional Overlap in Mismatch Repair by Human MSH3 and MSH6
Umar, A., Risinger, J. I., Glaab, W. E., Tindall, K. R., Barrett, J. C., & Kunkel, T. A. (1998) · Genetics · doi:10.1093/genetics/148.4.1637 · Cited by 151 · see citing works
Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast
Pavlov, Y. I., Mian, I. M., & Kunkel, T. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00284-7 · Cited by 149 · see citing works
MUTYH-Null Mice Are Susceptible to Spontaneous and Oxidative Stress–Induced Intestinal Tumorigenesis
Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4802 · Cited by 141 · see citing works
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
Kadyrov, F. A., Genschel, J., Fang, Y., Penland, E., Edelmann, W., & Modrich, P. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903654106 · Cited by 138 · see citing works
Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg, E. C., Linnoila, R. I., & Fornace, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503133102 · Cited by 135 · see citing works
Common Genetic Variants and Risk for HPV Persistence and Progression to Cervical Cancer
WANG, S. S., González, P., Yu, K. F., Porras, C., Li, Q., Safaeian, M., Rodríguez, A. C., Sherman, M. E., Bratti, C., SCHIFFMAN, M. H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008667 · Cited by 134 · see citing works
Cancers beget mutations versus mutations beget cancers.
Prehn, R. T. (1994) · PubMed · Cited by 133 · see citing works
Shcherbakova, P. V., & Pavlov, Y. I. (1996) · Genetics · doi:10.1093/genetics/142.3.717 · Cited by 130 · see citing works
Caretaker tumour suppressor genes that defend genome integrity
Levitt, N. C., & Hickson, I. D. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02298-0 · Cited by 130 · see citing works
Iida, T., & Araki, H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.217-227.2004 · Cited by 130 · see citing works
Problems of somatic mutation and cancer
Frank, S. A., & Nowak, M. A. (2004) · BioEssays · doi:10.1002/bies.20000 · Cited by 126 · see citing works
Marsischky, G., & Kolodner, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26668 · Cited by 126 · see citing works
Feng, W., & D’Urso, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4495-4504.2001 · Cited by 125 · see citing works
Mouse models for human DNA mismatch-repair gene defects
Wei, K., Kucherlapati, R., & Edelmann, W. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02359-6 · Cited by 124 · see citing works
Polymerase δ variants in RER colorectal tumours
da Costa, L. T., Liu, B., El‐Deiry, W. S., Hamilton, S. R., Kinzler, K. W., Vogelstein, B., Markowitz, S. D., Willson, J. K. V., de la Chapelle, A., Downey, K. M., et al. (1995) · Nature Genetics · doi:10.1038/ng0195-10 · Cited by 124 · see citing works
Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes
Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123 · see citing works
Cancer genetics: from Boveri and Mendel to microarrays
Balmain, A. (2001) · Nature reviews. Cancer · doi:10.1038/35094086 · Cited by 122 · see citing works
In Vivo Consequences of Putative Active Site Mutations in Yeast DNA Polymerases α, ε, δ, and ζ
Pavlov, Y. I., Shcherbakova, P. V., & Kunkel, T. A. (2001) · Genetics · doi:10.1093/genetics/159.1.47 · Cited by 122 · see citing works
Yeast Origins Establish a Strand Bias for Replicational Mutagenesis
Pavlov, Y. I., Newlon, C. S., & Kunkel, T. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00567-1 · Cited by 119 · see citing works
Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells
Papouli, E., Ćejka, P., & Jiricny, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0513 · Cited by 116 · see citing works
DNA polymerase epsilon may be dispensable for SV40‐ but not cellular‐DNA replication.
Zlotkin, T., Kaufmann, G., Jiang, Y. Q., Lee, M. Y., Uitto, L., Syväoja, J. E., Dornreiter, I., Fanning, E., & Nethanel, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00583.x · Cited by 115 · see citing works
Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01076-06 · Cited by 111 · see citing works
Transfer of the MSH2·MSH6 Complex from Proliferating Cell Nuclear Antigen to Mispaired Bases in DNA
Lau, P. J., & Kolodner, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200627200 · Cited by 110 · see citing works
Tahirov, T. H., Makarova, K. S., Rogozin, I. B., Pavlov, Y. I., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-11 · Cited by 110 · see citing works
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis
Chao, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj489 · Cited by 105 · see citing works
Venkatesan, R. N., Treuting, P. M., Fuller, E. D., Goldsby, R. E., Norwood, T. H., Gooley, T. A., Ladiges, W., Preston, B. D., & Loeb, L. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00002-07 · Cited by 102 · see citing works
Self-citationThe Protein Components and Mechanism of Eukaryotic Okazaki Fragment Maturation
Kao, H.-I., & Bambara, R. A. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230390259382 · Cited by 100 · see citing works
Mutator phenotypes of yeast strains heterozygous for mutations in the MSH 2 gene
Drotschmann, K., Clark, A., Tran, H. T., Resnick, M. A., Gordenin, D. A., & Kunkel, T. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2970 · Cited by 99 · see citing works
York, S. J., & Modrich, P. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603667200 · Cited by 98 · see citing works
Significance of error‐avoiding mechanisms for oxidative DNA damage in carcinogenesis
Tsuzuki, T., Nakatsu, Y., & Nakabeppu, Y. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00409.x · Cited by 98 · see citing works
Different DNA repair strategies to combat the threat from 8-oxoguanine
Russo, M. T., Luca, G. D., Degan, P., & Bignami, M. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.03.007 · Cited by 95 · see citing works
Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice
Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95 · see citing works
Saccharomyces cerevisiae Msh2-Msh3 Acts in Repair of Base-Base Mispairs
Harrington, J. M., & Kolodner, R. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00855-07 · Cited by 93 · see citing works
DNA polymerases and human diseases
Sweasy, J. B., Lauper, J. M., & Eckert, K. A. (2006) · Radiation Research · doi:10.1667/rr0706.1 · Cited by 93 · see citing works
Ohya, T., Kawasaki, Y., Hiraga, S., Kanbara, S., Nakajo, K., Nakashima, N., Suzuki, A., & Sugino, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111573200 · Cited by 92 · see citing works
Sigurdson, A. J., Hauptmann, M., Chatterjee, N., Alexander, B. H., Doody, M. M., Rutter, J. L., & Struewing, J. P. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-9 · Cited by 92 · see citing works
Hegan, D. C., Narayanan, L., Jirik, F. R., Edelmann, W., Liskay, R. M., & Glazer, P. M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl079 · Cited by 90 · see citing works
Edwards, S., Li, C. M., Levy, D. L., Brown, J. A., Snow, P. M., & Campbell, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2733-2748.2003 · Cited by 88 · see citing works
Fuss, J. O., & Linn, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110615200 · Cited by 87 · see citing works
Kokoska, R. J., Stefanovic, L., DeMai, J., & Petes, T. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7490-7504.2000 · Cited by 86 · see citing works
Mismatch repair proteins as sensors of alkylation DNA damage
Wang, J. Y. J., & Edelmann, W. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.013 · Cited by 86 · see citing works
Mismatch repair and response to DNA-damaging antitumour therapies
Bignami, M., Casorelli, I., & Karran, P. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00569-0 · Cited by 81 · see citing works
Distinct roles of DNA polymerases delta and epsilon at the replication fork inXenopusegg extracts
Fukui, T., Yamauchi, K., Muroya, T., Akiyama, M., Maki, H., Sugino, A., & Waga, S. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00716.x · Cited by 80 · see citing works
Jin, Y. H., Garg, P., Stith, C. M. W., Al-Refai, H., Sterling, J. F., Murray, L. J. W., Kunkel, T. A., Resnick, M. A., Burgers, P., & Gordenin, D. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.461-471.2005 · Cited by 80 · see citing works
Cheo, D. L., Meira, L. B., Hammer, R. E., Burns, D. K., Doughty, A. T. B., & Friedberg, E. C. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70794-x · Cited by 78 · see citing works
Karthikeyan, R., Vonarx, E. J., Straffon, A. F. L., Simon, M., Faye, G., & Kunz, B. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3744 · Cited by 76 · see citing works
Venkatesan, R. N., Hsu, J. J., Lawrence, N. A., Preston, B. D., & Loeb, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510245200 · Cited by 75 · see citing works
Self-citationGenetic variation in the DNA repair genes is predictive of outcome in lung cancer
Matakidou, A., Galta, R. E., Webb, E. L., Rudd, M. F., Bridle, H. L., Eisen, T. G., & Houlston, R. S. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm190 · Cited by 74 · see citing works
Cheo, D. L., Meira, L. B., Burns, D. K., Reis, A., Issac, T., & Friedberg, E. C. (2000) · PubMed · Cited by 73 · see citing works
Daee, D. L., Mertz, T. M., & Shcherbakova, P. V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907526106 · Cited by 72 · see citing works
Cancer Genome Sequencing—An Interim Analysis
Fox, E., Salk, J. J., & Loeb, L. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1231 · Cited by 70 · see citing works
Genetic Instability Is Not a Requirement for Tumor Development
Bodmer, W. F. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6544 · Cited by 69 · see citing works
Buermeyer, A. B., Patten, C. W.-V., Baker, S. M., & Liskay, R. M. (1999) · PubMed · Cited by 68 · see citing works
Cancer: the evolved consequence of a destabilized genome
Anderson, G. R., Stoler, D. L., & Brenner, B. M. (2001) · BioEssays · doi:10.1002/bies.1149 · Cited by 66 · see citing works
Sokolsky, T. D., & Alani, E. (2000) · Genetics · doi:10.1093/genetics/155.2.589 · Cited by 65 · see citing works
Andrew, S. E., Reitmair, A. H., Fox, J. A., Hsiao, L., Francis, A., McKinnon, M. L., Mak, T. W., & Jirik, F. R. (1997) · Oncogene · doi:10.1038/sj.onc.1201180 · Cited by 65 · see citing works
Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.
Reitmair, A. H., Risley, R., Bristow, R. G., Wilson, T., Ganesh, A. N., Jang, A., Peacock, J., Benchimol, S., Hill, R. P., Mak, T. W., et al. (1997) · PubMed · Cited by 64 · see citing works
Flagged first, then by citations
10 of the 251 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- [5]Nowell PC The clonal evolution of tumor cell populations Science 1976 194 23 8 959840
- [39]Arzimanoglou II Gilbert F Barber HR Microsatellite instability in human solid tumors Cancer 1998 82 1808 20 9587112
- [84]Treuting PM Albertson TM Preston BD Case series: acute tumor lysis syndrome in mutator mice with disseminated lymphoblastic lymphoma Toxicol Pathol 2010 38 476 85 20190201
- [127]Karthikeyan R Vonarx EJ Straffon AF Simon M Faye G Kunz BA Evidence from mutational specificity studies that yeast DNA polymerases δ and ε replicate different DNA strands at an intracellular replication fork J Mol Biol 2000 299 405 19 10860748
- [215]Flohr T Dai JC Buttner J Popanda O Hagmuller E Thielmann HW Detection of mutations in the DNA polymerase δ gene of human sporadic colorectal cancers and colon cancer cell lines Int J Cancer 1999 80 919 29 10074927
Cited by
Sorted by citations
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Wang, Y., Waters, J., Leung, M. L., Unruh, A., Roh, W., Shi, X., Chen, K., Scheet, P., Vattathil, S., Liang, H., et al. (2014) · Nature · doi:10.1038/nature13600 · Cited by 1,029 · see citing works
Palles, C., Cazier, J., Howarth, K. M., Domingo, E., Jones, A. M., Broderick, P., Kemp, Z., Spain, S. L., Guarino, E., Salguero, I., et al. (2012) · Nature Genetics · doi:10.1038/ng.2503 · Cited by 995 · see citing works
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
Smith, M. T., Guyton, K., Gibbons, C., Fritz, J. M., Portier, C., Rusyn, I., DeMarini, D., Caldwell, J., Kavlock, R., Lambert, P., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509912 · Cited by 599 · see citing works
Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W. M., Chen, Y., Harrison, D. G., & Bhatnagar, A. (2016) · Circulation Research · doi:10.1161/res.0000000000000110 · Cited by 452 · see citing works
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes
Kim, T., Laird, P. W., & Park, P. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.015 · Cited by 379 · see citing works
Shlien, A., Campbell, B. B., de Borja, R., Alexandrov, L. B., Merico, D., Wedge, D. C., Loo, P. V., Tarpey, P. S., Coupland, P. G., Behjati, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3202 · Cited by 374 · see citing works
Cancer genomics: one cell at a time
Navin, N. E. (2014) · Genome biology · doi:10.1186/s13059-014-0452-9 · Cited by 311 · see citing works
Accuracy of Next Generation Sequencing Platforms
Fox, E., & Reid-Bayliss, K. S. (2014) · Journal of Next Generation Sequencing & Applications · doi:10.4172/2469-9853.1000106 · Cited by 247 · see citing works
Genetic causes of microcephaly and lessons for neuronal development
Gilmore, E. C., & Walsh, C. A. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.89 · Cited by 244 · see citing works
Current Perspectives in Cancer Immunotherapy
Christofi, T., Baritaki, S., Falzone, L., Libra, M., & Zaravinos, A. (2019) · Cancers · doi:10.3390/cancers11101472 · Cited by 208 · see citing works
Genomic Instability in CancerPreprint
Abbas, T., Keaton, M., & Dutta, A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012914 · Cited by 200 · see citing works
DNA replication fidelity in Escherichia coli : a multi-DNA polymerase affair
Fijałkowska, I. J., Schaaper, R. M., & Jonczyk, P. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00338.x · Cited by 162 · see citing works
Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities
Zhang, C., & Zhang, F. (2014) · Protein & Cell · doi:10.1007/s13238-014-0119-z · Cited by 146 · see citing works
DNA Replication—A Matter of Fidelity
Ganai, R. A., & Johansson, E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.003 · Cited by 148 · see citing works
POLE/POLD1 mutation and tumor immunotherapy
Ma, X., Lin, D., Liu, X., Ou, K., & Yang, L. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02422-1 · Cited by 143 · see citing works
Nicolas, É., Golemis, E. A., & Arora, S. (2016) · Gene · doi:10.1016/j.gene.2016.06.031 · Cited by 134 · see citing works
DNA polymerase delta in dna replication and genome maintenance
Prindle, M. J., & Loeb, L. A. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21745 · Cited by 133 · see citing works
Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies
Lee, J. J.-K., Choi, Y., Kwon, M., & Park, P. J. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044446 · Cited by 132 · see citing works
Going beyond five bases in DNA sequencing
Korlach, J., & Turner, S. W. (2012) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2012.04.002 · Cited by 125 · see citing works
Elsayed, F. A., Kets, C. M., Ruano, D., van den Akker, B., Mensenkamp, A. R., Schrumpf, M., Nielsen, M., Wijnen, J., Tops, C. M. J., Ligtenberg, M. J. L., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.242 · Cited by 121 · see citing works
Erson-Omay, Z., Çağlayan, A. O., Schultz, N. D., Weinhold, N., Omay, S. B., Özduman, K., Köksal, Y., Li, J., Harmancı, A. S., Clark, V. E., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov027 · Cited by 116 · see citing works
Singh, N. P., Nambiar, D. K., Kale, R. K., & Singh, R. P. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.785007 · Cited by 111 · see citing works
Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy
Mandal, R., & Chan, T. A.-T. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0146 · Cited by 111 · see citing works
Durno, C. A., Ercan, A. B., Bianchi, V., Edwards, M., Aronson, M. D., Galati, M. A., Atenafu, E. G., Campino, G. A., Al-Battashi, A., Alharbi, M., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02636 · Cited by 108 · see citing works
Do mutator mutations fuel tumorigenesis?
Fox, E. J., Prindle, M. J., & Loeb, L. A. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9426-8 · Cited by 101 · see citing works
Yang, C., Tian, C., Hoffman, T. E., Jacobsen, N. K., & Spencer, S. L. (2021) · Nature Communications · doi:10.1038/s41467-021-21549-x · Cited by 94 · see citing works
Direct Detection and Sequencing of Damaged DNA Bases
Clark, T. A., Spittle, K. E., Turner, S. W., & Korlach, J. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-10 · Cited by 88 · see citing works
DeGregori, J. V. (2012) · Oncogene · doi:10.1038/onc.2012.281 · Cited by 84 · see citing works
Melanoma epigenetics: novel mechanisms, markers, and medicines
Lee, J. J., Murphy, G. F., & Lian, C. G. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.87 · Cited by 84 · see citing works
Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast
Herr, A. J., Ogawa, M., Lawrence, N. A., Williams, L. N., Eggington, J. M., Singh, M., Smith, R. A., & Preston, B. D. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002282 · Cited by 76 · see citing works
Self-citationHodel, K. P., Sun, M. J. S., Ungerleider, N., Park, V. S., Williams, L. G., Bauer, D. L., Immethun, V. E., Wang, J., Suo, Z., Lu, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.012 · Cited by 70 · see citing works
Casey, L., & Singh, N. (2020) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000000710 · Cited by 68 · see citing works
Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management
Dörk, T., Hillemanns, P., Tempfer, C. M., Breu, J., & Fleisch, M. C. (2020) · Cancers · doi:10.3390/cancers12092407 · Cited by 66 · see citing works
Implications of genetic heterogeneity in cancer
Schmitt, M. W., Prindle, M. J., & Loeb, L. A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06590.x · Cited by 65 · see citing works
Differentiation-Related Response to DNA Breaks in Human Mesenchymal Stem Cells
Oliver, L., Hue, E. S., Séry, Q., Lafargue, A. M., Pecqueur, C., Paris, F., & Vallette, F. M. (2013) · Stem Cells · doi:10.1002/stem.1336 · Cited by 65 · see citing works
Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease
Queitsch, C., Carlson, K. D., & Girirajan, S. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003041 · Cited by 61 · see citing works
Suwa, Y., Gu, J., Baranovskiy, A. G., Babayeva, N. D., Pavlov, Y. I., & Tahirov, T. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.649954 · Cited by 61 · see citing works
KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance
Ash, L. J., Busia-Bourdain, O., Okpattah, D., Kamel, A., Liberchuk, A., & Wolfe, A. L. (2024) · Current Oncology · doi:10.3390/curroncol31040150 · Cited by 59 · see citing works
“In mutant KRAS cells, the presence of the wildtype allele can drive resistance to downstream pathway inhibitors including MEK [108].”
BackgroundDNA polymerase beta (pol β) inhibitors: A comprehensive overview
Barakat, K., Gajewski, M. M., & Tuszyński, J. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.04.008 · Cited by 58 · see citing works
Mutational signatures and mutable motifs in cancer genomes
Rogozin, I. B., Pavlov, Y. I., Goncearenco, A., De, S., Lada, A. G., Poliakov, E., Panchenko, A. R., & Cooper, D. N. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbx049 · Cited by 58 · see citing works
Mechanisms of Base Substitution Mutagenesis in Cancer Genomes
Bacolla, A., Cooper, D., & Vasquez, K. M. (2014) · Genes · doi:10.3390/genes5010108 · Cited by 52 · see citing works
Nohara, K., Tateishi, Y., Suzuki, T., Okamura, K., Murai, H., Takumi, S., Maekawa, F., Nishimura, N., Kobori, M., & Ito, T. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs203 · Cited by 52 · see citing works
Age-related somatic mutation burden in human tissues
Ren, P., Dong, X., & Vijg, J. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1018119 · Cited by 51 · see citing works
Das, A., Fernandez, N. R., Levine, A., Bianchi, V., Stengs, L. K., Chung, J., Negm, L., Dimayacyac, J. R., Chang, Y., Nobre, L. F., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0559 · Cited by 50 · see citing works
Regulation of oxidative DNA damage repair: The adenine:8-oxo-guanine problem
Markkanen, E., Hübscher, U., & van Loon, B. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19448 · Cited by 50 · see citing works
POLE somatic mutations in advanced colorectal cancer
Guerra, J., Pinto, C., Pinto, D., Pinheiro, M., Silva, R., Peixoto, A., Rocha, P., Veiga, I., Santos, C., Santos, R. P., et al. (2017) · Cancer Medicine · doi:10.1002/cam4.1245 · Cited by 50 · see citing works
dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants
Williams, L. N., Marjavaara, L., Knowels, G. M., Schultz, E. M., Fox, E. J., Chabes, A., & Herr, A. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422948112 · Cited by 49 · see citing works
Self-citationLynch syndrome, molecular mechanisms and variant classification
Abildgaard, A. B., Nielsen, S. V., Bernstein, I., Stein, A., Lindorff‐Larsen, K., & Hartmann‐Petersen, R. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02059-z · Cited by 48 · see citing works
Hu, F., Zhu, X., Yang, H., Oh, J., Barbour, J. A., & Wong, J. W. H. (2021) · Science Advances · doi:10.1126/sciadv.abg4398 · Cited by 46 · see citing works
Decoding cell lineage from acquired mutations using arbitrary deep sequencing
Carlson, C. A., Kas, A., Kirkwood, R., Hays, L. E., Preston, B. D., Salipante, S. J., & Horwitz, M. S. (2011) · Nature Methods · doi:10.1038/nmeth.1781 · Cited by 46 · see citing works
Self-citationEmergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast
Williams, L. N., Herr, A. J., & Preston, B. D. (2013) · Genetics · doi:10.1534/genetics.112.146910 · Cited by 46 · see citing works
Self-citationWong, A., Kuick, C. H., Wong, W. L., Tham, J. M., Mansor, S., Loh, E., Jain, S., Vikas, N. N., Tan, S. H., Chan, S. H., et al. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.12.031 · Cited by 43 · see citing works
Non-LTR retrotransposons and microsatellites
Grandi, F. C., & An, W. (2013) · Mobile Genetic Elements · doi:10.4161/mge.25674 · Cited by 42 · see citing works
Intracellular Detection of Cytosine Incorporation in Genomic DNA by Using 5‐Ethynyl‐2′‐Deoxycytidine
Guan, L., van der Heijden, G. W., Bortvin, A. L., & Greenberg, M. M. (2011) · ChemBioChem · doi:10.1002/cbic.201100353 · Cited by 42 · see citing works
Use and validation of HT/HC assays to support 21st century toxicity evaluations
Patlewicz, G., Simon, T., Goyak, K., Phillips, R. D., Rowlands, J. C., Seidel, S. D., & Becker, R. A. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2012.12.008 · Cited by 40 · see citing works
Usman, M., Okla, M. K., Asif, H. M., AbdElgayed, G., Muccee, F., Ghazanfar, S., Ahmad, M., Iqbal, M. J., Sahar, A. M., Khaliq, G., et al. (2022) · PubMed Central · Cited by 41 · see citing works
Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexes
Kang, S., Kang, M.-S., Ryu, E., & Myung, K. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.04.002 · Cited by 38 · see citing works
Das, A., MacFarland, S. P., Meade, J. C., Hansford, J. R., Schneider, K. W., Kuiper, R. P., Jongmans, M. C. J., Lesmana, H. L., Schultz, K. A. P., Nichols, K. E., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3994 · Cited by 34 · see citing works
Wong, R. W.-C., Palicelli, A., Hoang, L. N., & Singh, N. (2020) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2020.03.002 · Cited by 35 · see citing works
Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining
Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J. J. F., Biezuner, T., Kaushansky, N., Minden, M. D., Gupta, V. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22803-y · Cited by 33 · see citing works
Advancing Small‐Molecule‐Based Chemical Biology with Next‐Generation Sequencing Technologies
Chandran, A., Kizaki, S., Bando, T., Pandian, G. N., & Sugiyama, H. (2014) · ChemBioChem · doi:10.1002/cbic.201402556 · Cited by 33 · see citing works
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Zhang, M., Yang, H. J., Hua, W., Zhong, L., Xu, Z., & Qian, Q. (2019) · Frontiers of Medicine · doi:10.1007/s11684-018-0678-0 · Cited by 32 · see citing works
Mismatch repair system proteins in oral benign and malignant lesions
do Amaral‐Silva, G. K., Martins, M. D., Pontes, H. A. R., Fregnani, E. R., Lopes, M. A., Fonseca, F. P., & Vargas, P. A. (2016) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12484 · Cited by 31 · see citing works
Ying, J., Yang, L., Yin, J. C., Xia, G., Xing, M., Chen, X., Pang, J., Wu, Y., Bao, H., Wu, X., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002336 · Cited by 31 · see citing works
Mertz, T. M., Baranovskiy, A. G., Wang, J., Tahirov, T. H., & Shcherbakova, P. V. (2017) · Oncogene · doi:10.1038/onc.2017.22 · Cited by 29 · see citing works
DNA damage in cancer development: special implications in viral oncogenesis.
Katerji, M., & Duerksen-Hughes, P. J. (2021) · PubMed Central · Cited by 29 · see citing works
Mitigating age-related somatic mutation burden
Vijg, J., Schumacher, B., Abakir, A., Antonov, M., Bradley, C., Cagan, A., Church, G. M., Gladyshev, V. N., Gorbunova, V. A., Maslov, A. Y., et al. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.04.002 · Cited by 30 · see citing works
Chitwood, D. G., Wang, Q., Elliott, K. S., Bullock, A., Jordana, D., Li, Z., Wu, C. H., Harcum, S. W., & Saski, C. A. (2021) · BMC Biotechnology · doi:10.1186/s12896-020-00667-2 · Cited by 27 · see citing works
A Novel Evolutionary Strategy Revealed in the Phaeoviruses
Stevens, K., Weynberg, K. D., Bellas, C. M., Brown, S., Brownlee, C., Brown, M. T., & Schroeder, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086040 · Cited by 26 · see citing works
The burden of faulty proofreading in colon cancer
Seshagiri, S. (2013) · Nature Genetics · doi:10.1038/ng.2540 · Cited by 26 · see citing works
The significance of genetics for cholangiocarcinoma development.
Maroni, L., Pierantonelli, I., Bañales, J. M., Benedetti, A., & Marzioni, M. (2013) · PubMed Central · doi:10.3978/j.issn.2305-5839.2012.10.04 · Cited by 26 · see citing works
Lebrec, H. N., Brennan, F. R., Haggerty, H. G., Herzyk, D., Kamperschroer, C., Maier, C. C., Ponce, R. A., Preston, B. D., Weinstock, D., & Mellon, R. D. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.12.018 · Cited by 24 · see citing works
Self-citationCancer as a global health crisis with deep evolutionary roots
Klement, R. J. (2024) · Global Transitions · doi:10.1016/j.glt.2024.01.001 · Cited by 25 · see citing works
Antimutator variants of DNA polymerases
Herr, A. J., Williams, L. N., & Preston, B. D. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.620941 · Cited by 24 · see citing works
Self-citationAbdullahi, A., Wong, T. W. L., & Ng, S. S. M. (2023) · Cancer Medicine · doi:10.1002/cam4.6466 · Cited by 22 · see citing works
Human Pol ɛ-dependent replication errors and the influence of mismatch repair on their correction
Agbor, A. A., Goksenin, A. Y., LeCompte, K. G., Hans, S. H., & Pursell, Z. F. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.08.012 · Cited by 22 · see citing works
Wallace, M. D., Southard, T. L., Schimenti, K. J., & Schimenti, J. C. (2013) · Oncogene · doi:10.1038/onc.2013.339 · Cited by 22 · see citing works
Biological and Therapeutic Relevance of Nonreplicative DNA Polymerases to Cancer
Parsons, J. L., Nicolay, N. H., & Sharma, R. A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4203 · Cited by 21 · see citing works
Zahurancik, W. J., Klein, S. J., & Suo, Z. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1184 · Cited by 22 · see citing works
DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer
Pavlov, Y., Zhuk, A., & Stepchenkova, E. (2020) · Cancers · doi:10.3390/cancers12123489 · Cited by 19 · see citing works
Konstantinova, V., Ibrahim, M. Y., Lie, S. A., Birkeland, E. S., Neppelberg, E., Marthinussen, M. C., Costea, D. E., & Cimpan, M. R. (2016) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12469 · Cited by 21 · see citing works
Cell-cell fusion in cancer: The next cancer hallmark?
Shultes, P. V., Weaver, D., Tadele, D., Barker-Clarke, R., & Scott, J. G. (2024) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2024.106649 · Cited by 14 · see citing works
Agents of cancer immunosurveillance: HSPs and dsDNA
Nayak, D. A., & Binder, R. J. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.03.004 · Cited by 21 · see citing works
Replication DNA polymerases, genome instability and cancer therapies
Strauss, J. D., & Pursell, Z. F. (2023) · NAR Cancer · doi:10.1093/narcan/zcad033 · Cited by 19 · see citing works
Tissue evolution: mechanical interplay of adhesion, pressure, and heterogeneity
Büscher, T., Ganai, N., Gompper, G., & Elgeti, J. (2020) · New Journal of Physics · doi:10.1088/1367-2630/ab74a5 · Cited by 19 · see citing works
Quantum Biology: Does quantum physics hold the key to revolutionizing medicine?
Goh, B. H., Tong, E. S., & Pusparajah, P. (2020) · Progress in Drug Discovery & Biomedical Science · doi:10.36877/pddbs.a0000130 · Cited by 19 · see citing works
Identifying genetic errors of immunity due to mosaicism
Schmitz, E. G., Griffith, M., Griffith, O. L., & Cooper, M. A. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241045 · Cited by 17 · see citing works
Gong, X., Cheng, J., Zhang, K., Wang, Y., Li, S., & Luo, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114646 · Cited by 17 · see citing works
Vageli, D. P., Giannopoulos, S., Doukas, S. G., Kalaitzis, C., Giannakopoulos, S., Giatromanolaki, A. N., Koukoulis, G. Κ., & Touloupidis, S. (2012) · Oncology Letters · doi:10.3892/ol.2012.979 · Cited by 16 · see citing works
POLE and POLD1 pathogenic variants in the proofreading domain in papillary thyroid cancer
Siraj, A. K., Bu, R., Arshad, M., Iqbal, K., Parvathareddy, S. K., Masoodi, T., Ghazwani, L. O., Al-Sobhi, S. S., Al‐Dayel, F., & Al-Kuraya, K. S. (2020) · Endocrine Connections · doi:10.1530/ec-20-0258 · Cited by 16 · see citing works
Replicating Damaged DNA in EukaryotesPreprint
Chatterjee, N., & Siede, W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019836 · Cited by 17 · see citing works
Frequent homozygous deletions of the CDKN2A locus in somatic cancer tissues
Hamid, A. B., Petreaca, B., & Petreaca, R. C. (2019) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2019.04.002 · Cited by 14 · see citing works
Correction: Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast
Herr, A. J., Ogawa, M., Lawrence, N. A., Williams, L. N., Eggington, J. M., Singh, M., Smith, R. A., & Preston, B. D. (2011) · PLoS Genetics · doi:10.1371/annotation/db1d9553-4ebd-4015-a1cd-c483dbc0d7e5 · Cited by 14 · see citing works
Self-citationMaking sense of mRNA translational “noise”
Mao, Y., & Qian, S. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.03.004 · Cited by 15 · see citing works
The Yeast PCNA Unloader Elg1 RFC-Like Complex Plays a Role in Eliciting the DNA Damage Checkpoint
Sau, S., Liefshitz, B., & Kupiec, M. (2019) · mBio · doi:10.1128/mbio.01159-19 · Cited by 13 · see citing works
Volatility of Mutator Phenotypes at Single Cell Resolution
Kennedy, S. R., Schultz, E. M., Chappell, T. M., Kohrn, B. F., Knowels, G. M., & Herr, A. J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005151 · Cited by 13 · see citing works
Self-citationDeshmukh, A. L., Kumar, C., Singh, D. K., Maurya, P., & Banerjee, D. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.04.010 · Cited by 12 · see citing works
Weber, C. A. M., Krönke, N., Volk, V., Auber, B., Förster, A., Trost, D., Geffers, R., Esmaeilzadeh, M., Lalk, M., Nabavi, A., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01689-5 · Cited by 10 · see citing works
Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome Sequencing
Zhang, L., Cecco, M. D., Lee, M., Hao, X., Maslov, A. Y., Montagna, C., Campisi, J., Dong, X., Sedivy, J. M., & Vijg, J. (2023) · doi:10.59368/agingbio.20230005 · Cited by 10 · see citing works
Mismatch Repair Proteins in Recurrent Prostate Cancer
Jarzen, J., Diamanduros, A., & Scarpinato, K. D. (2013) · Advances in clinical chemistry · doi:10.1016/b978-0-12-407681-5.00002-7 · Cited by 10 · see citing works
- Authors
- Preston, B. D., Albertson, T. M., & Herr, A. J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Preston, Bradley D.
- ORCID
- Herr, Alan J.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 20
- Issue
- 5
- Pages
- 281-293
- ISSN
- 1044-579X (ISSN-L)
- PMC
- PMC2993855
- OpenAlex
- W2056156376
- Cited by
- 160
- References
- 251
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 17 · 2012: 16
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cancer Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG001751)
- National Cancer Institute (P20CA103728, R01CA111582, P01CA077852, R01CA098243)
- National Institute of Environmental Health Sciences (R01ES009927, P30ES007033)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- DNA replication fidelity, carcinogenesis, replication errors, mutation avoidance, positive selection, genome stability
- MeSH terms
- Animals, Chromosome Aberrations, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Humans, Mutation, Neoplasms, Gene Rearrangement, Point Mutation, Microsatellite Instability, DNA Mismatch Repair
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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