The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Immunity to Citrullinated Proteins in Rheumatoid Arthritis
Abstract
Antibodies to citrullinated proteins (ACPA), i.e., to peptides posttranslationally modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA). Studies on anticitrulline immunity, summarized in this review, demonstrate that the criterion-based syndrome RA should be subdivided into at least two distinct subsets (ACPA-positive and ACPA-negative disease). A new etiological model is proposed for ACPA-positive RA, built on MHC class II–dependent activation of adaptive immunity. Fundamentals of this model include the following: (a) ACPA antedate onset of arthritis; (b) ACPA may aggravate arthritis in rodents; (c) ACPA are triggered in the context of genes that confer susceptibility to RA (HLA-DRB1 SE) and by environmental agents triggering RA (smoking or bacterial stimuli); (d) ACPA may complex with citrullinated proteins present in target tissue as part of a multistep process for arthritis development. The model provides a new basis for molecular studies on the pathogenesis of ACPA-positive arthritis.
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Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Plenge, R. M., Seielstad, M., Padyukov, L., Lee, A. T., Remmers, E. F., Ding, B., Liew, A., Khalili, H., Chandrasekaran, A., Davies, L. R. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073491 · Cited by 823
Self-citation
Cited by
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Sugiyama, D., Nishimura, K., Tamaki, K., Tsuji, G., Nakazawa, T., Morinobu, A., & Kumagai, S. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.096487 · Cited by 667
Autophagy and cellular immune responses
Ma, Y., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.017 · Cited by 447
Scally, S. W., Petersen, J., Law, S. C., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20131241 · Cited by 429
Recent Advances in the Genetics of Autoimmune Disease
Gregersen, P. K., & Olsson, L. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 339
Metadata
- Authors
- Klareskog, L., Rönnelid, J., Lundberg, K., Padyukov, L., & Alfredsson, L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 651-675
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2131872753
- Cited by
- 463
- References
- 2
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Klareskog, L., Rönnelid, J., Lundberg, K., Padyukov, L., & Alfredsson, L. (2008). Immunity to Citrullinated Proteins in Rheumatoid Arthritis. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090244
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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