The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE
Abstract
▪ Abstract Risk factor intervention is a useful strategy for prevention of poorly understood diseases. Fifteen studies have examined the relation of glucocorticoid and nonsteroid antiinflammatory treatments and onset or progression of Alzheimer's disease (AD). Fourteen of these studies suggest that such treatments (especially nonsteroidal agents) prevent or ameliorate symptoms of AD. Abundant circumstantial evidence implicates inflammation in the pathogenesis of AD. Inhibition of cyclooxygenases, the central action of nonsteroidal antiinflammatory drugs (but not a prominent effect of steroids), limits inflammation, but it may also alter neural metabolic pathways, resulting in cell death from excitotoxicity or oxidative stress. Randomized controlled trials are needed to determine whether steroids, nonsteroidal antiinflammatory drugs, or both can prevent or treat the symptoms of AD.
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Cites
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
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Cited by
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Innate immune activation in neurodegenerative disease
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MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
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Innate immunity in Alzheimer's disease
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Metadata
- Authors
- Breitner, M. D.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1996-02
- Volume
- 47
- Issue
- 1
- Pages
- 401-411
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2148152028
- Cited by
- 263
- References
- 8
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE. https://app.cochat.ai/papers/10.1146/annurev.med.47.1.401
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- Breitner, M. D. (1996). THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.47.1.401
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
