Cited by 984Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsMultiple Sclerosis Research Studies

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., Baltuch, Gordon·1999·Annual Review of Neuroscience

Abstract

▪ Abstract Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

Integrity signals

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Crossref · 10.1146/annurev.neuro.22.1.219

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128 of 128 references verified0 citation errors · 0 not checkable

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Authors
González-Scarano, F., & Baltuch, G.
Affiliations
  • Departments of 1Neurology and Microbiology; and 2Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6146;
  • University of Pennsylvania (US)
Venue
Annual Review of Neuroscience
Published
1999-03
Volume
22
Issue
1
Pages
219-240
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2146901670
Cited by
984
References
129
Citations by year
2026: 2 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 18 · 2021: 25 · 2020: 15 · 2019: 25 · 2018: 37 · 2017: 37 · 2016: 23 · 2015: 40 · 2014: 32 · 2013: 38 · 2012: 51
FWCI
4.95
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS35743, NS 27405, R01NS035743)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
microglia, neuroinflammation, neurodegeneration, multiple sclerosis, Alzheimer's disease, central nervous system immunity, viral persistence, neuroprotection
MeSH terms
Alzheimer Disease, Animals, Central Nervous System Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, HIV Infections, Microglia

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