The DOI matches its Crossref record.
Tissue Engineering: Current State and Prospects
Abstract
▪ Abstract Organ shortage and suboptimal prosthetic or biological materials for repair or replacement of diseased or destroyed human organs and tissues are the main motivation for increasing research in the emerging field of tissue engineering. No organ or tissue is excluded from this multidisciplinary research field, which aims to provide vital tissues with the abilities to function, grow, repair, and remodel. There are several approaches to tissue engineering, including the use of cells, scaffolds, and the combination of the two. The most common approach is biodegradable or resorbable scaffolds configured to the shape of the new tissue (e.g. a heart valve). This scaffold is seeded with cells, potentially derived from either biopsies or stem cells. The seeded cells proliferate, organize, and produce cellular and extracellular matrix. During this matrix formation, the starter matrix is degraded, resorbed, or metabolized. First clinical trials using skin or cartilage substitutes are currently under way. Both the current state of the field and future prospects are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds
Reddy, M. S. B., Ponnamma, D., Choudhary, R., & Sadasivuni, K. K. (2021) · Polymers · doi:10.3390/polym13071105 · Cited by 1,104
Stem cells in tissue engineering
Bianco, P., & Robey, P. G. (2001) · Nature · doi:10.1038/35102181 · Cited by 965
Hierarchically biomimetic bone scaffold materials: nano‐HA/collagen/PLA composite
Liao, S. S., Cui, F. Z., Zhang, W., & Feng, Q. L. (2004) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.20035 · Cited by 487
Shimizu, T., Sekine, H., Yang, J., Isoi, Y., Yamato, M., Kikuchi, A., Kobayashi, E., & Okano, T. (2006) · The FASEB Journal · doi:10.1096/fj.05-4715fje · Cited by 478
Metadata
- Authors
- Stock, U. A., & Vacanti, J. P.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2001-02
- Volume
- 52
- Issue
- 1
- Pages
- 443-451
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2170597721
- Cited by
- 483
- References
- 0
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tissue Engineering: Current State and Prospects. https://app.cochat.ai/papers/10.1146/annurev.med.52.1.443
- The paper
- Stock, U. A., & Vacanti, J. P. (2001). Tissue Engineering: Current State and Prospects. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.52.1.443
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
