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Complement Evasion by Bacteria and Parasites
Abstract
INTRODUCTION ... ........ ... .. ....... .. 201 THE COMPLEMENT SYSTEM: AN OVERVIEW ........ ..... 202 Cl Activation and Control .... .... ...... ........ 203 C3 Chemistry. .... .. ...... .. .... 203 Control of Alternative Pathway Activation. ....... ... .... 205 C3 Receptors ... ... ..... ..... .. 206 C5b-9 and Poly C9 Formation ... .... ........ . 206 Control Proteins .... .... .... .. .... 207 STRATEGIES OF COMPLEMENT EVASION .. .. ...... .... 208 Failure to Activate Complement .... ..... .... 208 Microbial Shedding of Molecules that Activate or Destroy Complement ..... ...... 2 1 1 Synthesis or Acquisition of Regulatory Molecules. .... .... .. 2 1 2 Blockade of Activation Before C5b-9 Formation ...... .... .. ..... 2 1 4 Formation of a Nonlytic C5b-9 Complex .... .... ... .. 2 16 Hypothetical Mechanisms for Complement Resistance a t the C5b-9 Step 2 1 9 Microbial Use of Complement Receptors t o Gain Access to Intracellular Locations .. ....... ..... ...... .. .. .... 219 CONCLUSIONS .... :. 221
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Citations
Cited by
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404
Podschun, R., & Ullmann, U. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.4.589 · Cited by 2,688
Biosynthesis and Export of Bacterial Lipopolysaccharides
Whitfield, C., & Trent, M. S. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035600 · Cited by 709
The human mannose-binding protein functions as an opsonin.
Kuhlman, M., Joiner, K., & Ezekowitz, R. A. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.5.1733 · Cited by 434
Self-citationComplement control protein factor H: The good, the bad, and the inadequate
Ferreira, V. P., Pangburn, M. K., & Cortés, C. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.05.007 · Cited by 420
Metadata
- Authors
- Joiner, K. A.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1988-10
- Volume
- 42
- Issue
- 1
- Pages
- 201-230
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2174380698
- Cited by
- 292
- References
- 0
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Joiner, K. A. (1988). Complement Evasion by Bacteria and Parasites. Annual Review of Microbiology. https://doi.org/10.1146/annurev.mi.42.100188.001221
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.