The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
rRNA TRANSCRIPTION AND GROWTH RATE–DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI
Abstract
The synthesis of ribosomal RNA is the rate-limiting step in ribosome synthesis in bacteria. There are multiple mechanisms that determine the rate of rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional strength and for regulation in response to nutritional conditions and amino acid availibility. Strength derives in part from an extended RNA polymerase (RNAP) recognition region involving at least two RNAP subunits, in part from activation by a transcription factor and in part from modification of the transcript by a system that prevents premature termination. Regulation derives from at least two mechanistically distinct systems, growth rate–dependent control and stringent control. The mechanisms contributing to rRNA transcription work together and compensate for one another when individual systems are rendered inoperative.
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Cites
Control of rRNA transcription in Escherichia coli
Condon, C., Squires, C., & Squires, C. L. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.623-645.1995 · Cited by 349
Cited by
Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6
Volarević, S., Stewart, M. J., Ledermann, B., Zilberman, F., Terracciano, L., Montini, E., Grompe, M., Kozma, S. C., & Thomas, G. (2000) · Science · doi:10.1126/science.288.5473.2045 · Cited by 373
Control of rRNA Expression by Small Molecules Is Dynamic and Nonredundant
Murray, H. D., Schneider, D. A., & Gourse, R. L. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00266-1 · Cited by 191
Self-citationMetal limitation of cyanobacterial N2fixation and implications for the Precambrian nitrogen cycle
ZERKLE, A. L., HOUSE, C. H., COX, R. P., & CANFIELD, D. E. (2006) · Geobiology · doi:10.1111/j.1472-4669.2006.00082.x · Cited by 149
The GTP binding protein Obg homolog ObgE is involved in ribosome maturation.
Sato, A., Kobayashi, G., Hayashi, H., Yoshida, H., Wada, A., Maeda, M., Hiraga, S., Takeyasu, K., & Wada, C. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00851.x · Cited by 135
Strategy of Transcription Regulation in the Budding Yeast
Levy, S., Ihmels, J., Carmi, M., Weinberger, A., Friedlander, G., & Barkai, N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000250 · Cited by 72
“In bacteria, the rate of ribosome synthesis increases approximately with the square of the growth rate [10].”
Metadata
- Authors
- Gourse, R. L., Gaal, T., Bartlett, M. S., Appleman, J. A., & Ross, W.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1996-10
- Volume
- 50
- Issue
- 1
- Pages
- 645-677
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2159394948
- Cited by
- 264
- References
- 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: rRNA TRANSCRIPTION AND GROWTH RATE–DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI. https://app.cochat.ai/papers/10.1146/annurev.micro.50.1.645
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- Gourse, R. L., Gaal, T., Bartlett, M. S., Appleman, J. A., & Ross, W. (1996). rRNA TRANSCRIPTION AND GROWTH RATE–DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.50.1.645
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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