The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6
Abstract
Because ribosome biogenesis plays an essential role in cell proliferation, control mechanisms may have evolved to recognize lesions in this critical anabolic process. To test this possibility, we conditionally deleted the gene encoding 40 S ribosomal protein S6 in the liver of adult mice. Unexpectedly, livers from fasted animals deficient in S6 grew in response to nutrients even though biogenesis of 40 S ribosomes was abolished. However, liver cells failed to proliferate or induce cyclin E expression after partial hepatectomy, despite formation of active cyclin D–CDK4 complexes. These results imply that abrogation of 40 S ribosome biogenesis may induce a checkpoint control that prevents cell cycle progression.
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Cites
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Cited by
Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384
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The tor pathway: a target for cancer therapy
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MYC as a regulator of ribosome biogenesis and protein synthesis
van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956
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Metadata
- Authors
- Volarević, S., Stewart, M. J., Ledermann, B., Zilberman, F., Terracciano, L., Montini, E., Grompe, M., Kozma, S. C., & Thomas, G.
- Venue
- Science
- Published
- 2000-06-16
- Volume
- 288
- Issue
- 5473
- Pages
- 2045-2047
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073367697
- Cited by
- 373
- References
- 23
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Volarević, S., Stewart, M. J., Ledermann, B., Zilberman, F., Terracciano, L., Montini, E., Grompe, M., Kozma, S. C., & Thomas, G. (2000). Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6. Science. https://doi.org/10.1126/science.288.5473.2045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
