The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM
Abstract
▪ Abstract Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic pathway have been defined. Studies of protease biosynthesis have revealed unusual targeting and activation mechanisms. Oxygen radicals and heme are released during proteolysis and must be detoxified by dismutation and polymerization, respectively. The quinoline antimalarials appear to act by preventing sequestration of this toxic heme. Understanding the disposition of hemoglobin has allowed identification of essential processes and metabolic weakpoints that can be exploited to combat this scourge of mankind.
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Citations
Cites
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
Meshnick, S. R., Taylor, T. E., & Kamchonwongpaisan, S. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.301-315.1996 · Cited by 710 · cited 1×
“Instead, artemesinin toxicity appears to be the product of membrane damage that results from protein alkylation (86).”
BackgroundA malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., & Leech, J. H. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113766 · Cited by 331
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)
Meshnick, S. R., Yang, Y. Z., Lima, V, Kuypers, F., Kamchonwongpaisan, S., & Yuthavong, Y. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.5.1108 · Cited by 327
Cited by
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1586 · Cited by 560
A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides
O'Neill, P. M., & Posner, G. H. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030571c · Cited by 538
The struggle for iron - a metal at the host-pathogen interface: Iron at the host-pathogen interface
Nairz, M., Schroll, A., Sonnweber, T., & Weiss, G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01529.x · Cited by 398
Iron metabolism and the innate immune response to infection
Johnson, E. E., & Wessling-Resnick, M. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.001 · Cited by 253
“Both of these complexes can be taken up and cleared by macrophages, but they may also serve as iron sources for infectious agents such as Staphylococcus [19], Leishmania [30], Trypanosomes [31], and Plasmodium falciparum [32], the causative agent of malaria.”
BackgroundA central role for free heme in the pathogenesis of severe malaria: the missing link?
Ferreira, A., Balla, J., Jeney, V., Balla, G., & Soares, M. P. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0368-5 · Cited by 205
Metadata
- Authors
- Francis, S. E., Sullivan, D. J., & Goldberg, A. D. E.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 1997-10
- Volume
- 51
- Issue
- 1
- Pages
- 97-123
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2128378359
- Cited by
- 782
- References
- 3
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM. https://app.cochat.ai/papers/10.1146/annurev.micro.51.1.97
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- Francis, S. E., Sullivan, D. J., & Goldberg, A. D. E. (1997). HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.51.1.97
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
