Cited by 669Enzyme Production and CharacterizationPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

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Alginate Lyase: Review of Major Sources and Enzyme Characteristics, Structure-Function Analysis, Biological Roles, and Applications

Wong, Thiang Yian, Preston, Lori A., Schiller, Neal L.·2000·Annual Review of Microbiology

DOI 10.1146/annurev.micro.54.1.289

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Abstract

Alginate lyases, characterized as either mannuronate (EC 4.2.2.3) or guluronate lyases (EC 4.2.2.11), catalyze the degradation of alginate, a complex copolymer of alpha-L-guluronate and its C5 epimer beta-D-mannuronate. Lyases have been isolated from a wide range of organisms, including algae, marine invertebrates, and marine and terrestrial microorganisms. This review catalogs the major characteristics of these lyases, the methods for analyzing these enzymes, as well as their biological roles. Analysis of primary sequence data identifies some markedly conserved motifs that should help elucidate functional domains. Information about the three-dimensional structure of a mannuronate lyase from Sphingomonas sp., combined with various mutagenesis studies, has identified residues that are important for catalytic activity in several lyases. Characterization of alginate lyases will enhance and expand the use of these enzymes to engineer novel alginate polymers for applications in various industrial, agricultural, and medical fields. In this review, we explore both past and present applications of this important enzyme and discuss its future prospects.

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Atomic interactions in protein-carbohydrate complexes
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Alginate Lyases in the Hepatopancreas of a Marine Mollusc, Dolabella auricula Solander*
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Addition of a Bacterial Alginate Lyase to Purulent CF Sputum In Vitro Can Result in the Disruption of Alginate and Modification of Sputum Viscoelasticity
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Isolation and certain properties of alginate lyase VI from the mollusk Littorina sp
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Enzymatic degradation of alginate by marine fungi
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EXTRACELLULAR POLYSACCHARIDES OF AZOTOBACTER VINELANDII
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Isolation of protoplasts from edible seaweeds
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Sequence of a gene encoding a (poly ManA) alginate lyase active onPseudomonas aeruginosaalginate
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In Vitro Elution of Antibiotic from Antibiotic-Impregnated Biodegradable Calcium Alginate Wound Dressing
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HPLC analysis of saturated or unsaturated oligoguluronates and oligomannuronates. Application to the determination of the action pattern of Haliotis tuberculata alginate lyase
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Distribution of DNA and Alginate in Purulent Cystic Fibrosis Sputum: Implications to Pulmonary Targeting Strategies
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An effective method for isolating alginate lyase-producing Bacillus sp. ATB-1015 strain and purification and characterization of the lyase
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Alginate Lyase in the Brown Alga Laminaria digitata (Huds.) Lamour.
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Applications of some algal polysaccharides in biotechnology
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Purification and structural properties of an extracellular (1-4)-.beta.-D-mannuronan-specific alginate lyase from a marine bacterium
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Method Designed To Detect Alginate-Degrading Bacteria
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An Edible-to-insects Calcium Alginate Gel as a Carrier for Entomopathogenic Nematodes
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Isolation of protoplasts from zygotes of Fucus distichus (L.) powell (Phaeophyta)
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Sphingomonas sp. A1 lyase active on both poly-β-d-mannuronate and heteropolymeric regions in alginate
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Cloning, sequencing and overexpression in Escherichia coli of the alginatelyase-encoding aly gene of Pseudomonas alginovora: identification of three classes of alginate lyases
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Alginate Lyases of Pseudomonads*
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Isolation and Properties of Alginate Lyase from the Mid-Gut Gland of Wreath ShellTurbo cornutus
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Determination by a Kinetic Method of the Nearest-Neighbour Frequencies in a Fragment of Alginic Acid.
Larsen, B. A., Smidsrød, O., Haug, A., Painter, T. J., Rydberg, J. R., & Craig, J. C. (1969) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.23-2375 · Cited by 31
Primary structure of mannuronate lyases SP1 and SP2 fromTurbo cornutus and involvement of the hydrophobic C-terminal residues in the protein stability
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Purification and characteristics of an alginase from Alginovibrio aquatilis
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Role of lysine, tryptophan and calcium in the β-elimination activity of a low-molecular-mass pectate lyase from Fusarium moniliformae
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A better understanding of the properties of alginate solutions and gels by quantitative magnetic resonance imaging (MRI)
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A study of the reaction catalysed by alginate lyase VI from the sea mollusc, Littorina sp.
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Digestion of algin by Pseudomonas maltophilia and Pseudomonas putida
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Alginate Lyase Activities in the Extracts from Several Brown Algae.
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An enzymatic method for preparation of homopolymannuronate blocks and strictly alternating sequences of mannuronic and guluronic units
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Authors: Wong, T. Y., Preston, L. A., & Schiller, N. L.
Affiliations: University of California, Riverside (US)
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2000-10
Volume: 54
Issue: 1
Pages: 289-340
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev.micro.54.1.289
OpenAlex: W2136250029
Cited by: 669
References: 267
Citations by year: 2026: 25 · 2025: 26 · 2024: 45 · 2023: 34 · 2022: 36 · 2021: 30 · 2020: 45 · 2019: 38 · 2018: 44 · 2017: 30 · 2016: 42 · 2015: 47 · 2014: 32 · 2013: 32 · 2012: 29
FWCI: 0.80
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai036325-05)
National Institute of Allergy and Infectious Diseases (AI 36325)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: alginate lyase, alginate degradation, alginate depolymerization, enzyme structure-function, conserved motifs, Sphingomonas, catalytic residues, marine microorganisms, enzyme applications
MeSH terms: Alginates, Amino Acid Sequence, Animals, Gram-Negative Bacteria, Gram-Positive Bacteria, Invertebrates, Marine Biology, Molecular Sequence Data, Polysaccharide-Lyases, Eukaryota

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Alginate Lyase: Review of Major Sources and Enzyme Characteristics, Structure-Function Analysis, Biological Roles, and Applications

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