Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Liu, Jun; Yang, Shaoqing; Li, Xiuting; Yan, Qiaojuan; Reaney, Martin J. T.; Jiang, Zhengqiang

doi:10.1111/1541-4337.12494

Cited by 311Polysaccharides Composition and ApplicationsSeaweed-derived Bioactive CompoundsPolysaccharides and Plant Cell Walls

Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

Liu, Jun, Yang, Shaoqing, Li, Xiuting, Yan, Qiaojuan, Reaney, Martin J. T., Jiang, Zhengqiang·2019·Comprehensive Reviews in Food Science and Food Safety

DOI 10.1111/1541-4337.12494

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Abstract

Alginate, a group of polyuronic saccharides, has been widely used in both pharmaceutical and food industries due to its unique physicochemical properties as well as beneficial health effects. However, the potential applications of alginate are restricted because of its low water solubility and high solution viscosity when significant concentrations are needed, particularly in food products. Alginate oligosaccharides (AOS), oligomers containing 2 to 25 monomers, can be obtained via hydrolysis of glycosidic bonds, organic synthesis, or through biosynthesis. Generally, AOS have shorter chain lengths and thus improved water solubility when compared with higher molecular weight alginates of the same monomers. These oligosaccharides have attracted interest from both basic and applied researchers. AOS have unique bioactivity and can impart health benefits. They have shown immunomodulatory, antimicrobial, antioxidant, prebiotic, antihypertensive, antidiabetic, antitumor, anticoagulant, and other activities. As examples, they have been utilized as prebiotics, feed supplements for aquaculture, poultry, and swine, elicitors for plants and microorganisms, cryoprotectors for frozen foods, and postharvest treatments. This review comprehensively covers methods for AOS production from alginate, such as physical/chemical methods, enzymatic methods, fermentation, organic synthesis, and biosynthesis. Moreover, current progress in structural characterization, potential health benefits, and AOS metabolism after ingestion are summarized in this review. This review will discuss methods for producing and modified AOS with desirable structures that are suited for novel applications.

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Alginates and fucoidan are extracted from brown seaweeds, while carrageenan and agar are extracted from red seaweeds.
“Alginates and fucoidan are extracted from brown seaweeds, while carrageenan and agar are extracted from red seaweeds [72].”
From Key Targets for Improving Algal Biofuel Production (2021) · cites this paper as [72]

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Authors: Liu, J., Yang, S., Li, X., Yan, Q., Reaney, M. J. T., & Jiang, Z.
Affiliations: Beijing Technology and Business University (CN)
Beijing Advanced Innovation Center for Food Nutrition and Human Health (CN)
China Agricultural University (CN)
Jinan University (CN)
Corresponding author: Jiang, Zhengqiang
ORCID: Liu, Jun
Yang, Shaoqing
Li, Xiuting
Yan, Qiaojuan
Reaney, Martin J. T.
Jiang, Zhengqiang
Venue: Comprehensive Reviews in Food Science and Food Safety
Publisher: Wiley
Published: 2019-09-19
Volume: 18
Issue: 6
Pages: 1859-1881
ISSN: 1541-4337 (ISSN-L)
DOI: 10.1111/1541-4337.12494
OpenAlex: W2973529428
Cited by: 311
References: 233
Citations by year: 2026: 31 · 2025: 39 · 2024: 58 · 2023: 54 · 2022: 49 · 2021: 59 · 2020: 20 · 2019: 1
FWCI: 24.89
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Comprehensive Reviews in Food Science and Food Safety (publishedVersion)
PubMed (publishedVersion)
Funders: National Basic Research Program of China (2016YFD0400800, 2017YFD0400200)
National Natural Science Foundation of China (31272475)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords: alginate oligosaccharides, oligosaccharide production, enzymatic hydrolysis, fermentation, organic synthesis, biosynthesis, prebiotics, immunomodulation, antioxidant activity, antimicrobial activity, antihypertensive effect, antidiabetic activity, anticancer activity, anticoagulant activity, aquaculture feed supplement, plant defense elicitors, cryoprotectants, postharvest treatment, oligosaccharide metabolism, water solubility, alginate

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Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications

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