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DNA Mismatch Repair: Molecular Mechanisms and Biological Function
Abstract
▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired bases that arise through replication errors, during homologous recombination, and as a result of DNA damage. Cells deficient in MMR have a mutator phenotype in which the rate of spontaneous mutation is greatly elevated, and they frequently exhibit microsatellite instability at mono- and dinucleotide repeats. The importance of MMR in mutation avoidance is highlighted by the finding that defects in MMR predispose individuals to hereditary nonpolyposis colorectal cancer. In addition to its role in postreplication repair, the MMR machinery serves to police homologous recombination events and acts as a barrier to genetic exchange between species.
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Evolution of mutation rates in bacteria
Denamur, E., & Matic, I. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05150.x · Cited by 401
Epigenetic Changes in Prostate Cancer: Implication for Diagnosis and Treatment
Li, L.-C., Carroll, P. R., & Dahiya, R. (2005) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dji010 · Cited by 299
ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts
Yoshioka, K.-I., Yoshioka, Y., & Hsieh, P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.023 · Cited by 288
Self-citation
Metadata
- Authors
- Schofield, M. J., & Hsieh, P.
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2003-10
- Volume
- 57
- Issue
- 1
- Pages
- 579-608
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2165068523
- Cited by
- 492
- References
- 0
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schofield, M. J., & Hsieh, P. (2003). DNA Mismatch Repair: Molecular Mechanisms and Biological Function. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.57.030502.090847
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