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Cited by 586

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The Small RNA Regulators of Escherichia coli : Roles and Mechanisms

Gottesman, Susan·2004·Annual Review of Microbiology

Abstract

▪ Abstract Small noncoding RNAs have been found in all organisms, primarily as regulators of translation and message stability. The most exhaustive searches have taken place in E. coli, resulting in identification of more than 50 small RNAs, or 1%–2% of the number of protein-coding genes. One large class of these small RNAs uses the RNA chaperone Hfq; members of this class act by pairing to target messenger RNAs. Among the members of this class are DsrA and RprA, which positively regulate rpoS translation, OxyS, which negatively regulates rpoS translation and fhlA translation, RyhB, which reapportions iron use in the cell by downregulating translation of many genes that encode Fe-containing proteins, and Spot 42, which changes the polarity of translation in the gal operon. The promoters of these small RNAs are tightly regulated, frequently as part of well-understood regulons. Lessons learned from the study of small RNAs in E. coli can be applied to finding these important regulators in other organisms.

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Metadata

Authors
Gottesman, S.
Venue
Annual Review of Microbiology
Published
2004-10-01
Volume
58
Issue
1
Pages
303-328
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
OpenAlex
W2130168792
Cited by
586
References
2
FWCI
3.99
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Small RNA Regulators of Escherichia coli : Roles and Mechanisms. https://app.cochat.ai/papers/10.1146/annurev.micro.58.030603.123841
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Gottesman, S. (2004). The Small RNA Regulators of Escherichia coli : Roles and Mechanisms. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.58.030603.123841

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