Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,750

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Noise in Gene Expression: Origins, Consequences, and Control

Open access
Raser, Jonathan M., O'Shea, Erin K.·2005·Science

Abstract

Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation, in the process of gene expression may contribute to this phenotypic variability. Recent studies suggest that this noise has multiple sources, including the stochastic or inherently random nature of the biochemical reactions of gene expression. In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1105891

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 32

  1. 10.1126/science.1109090 · DOI · Paper page
  2. 10.1038/ng869 · DOI · Paper page
  3. 10.1073/pnas.94.3.814 · DOI · Paper page
  4. A. M. Kierzek, J. Zaim, P. Zielenkiewicz, J. Biol. Chem.276, 8165 (2001). · DOI · Paper page
  5. 10.1016/S0006-3495(01)75949-8 · DOI · Paper page
  6. 10.1038/nature01546 · DOI · Paper page
  7. 10.1126/science.1106914 · DOI · Paper page
  8. 10.1016/S0092-8674(01)00281-1 · DOI
  9. 10.1126/science.281.5381.1352 · DOI
  10. 10.1016/S1074-7613(00)80604-4 · DOI · Paper page
  11. 10.1152/physiolgenomics.00163.2003 · DOI · Paper page
  12. R. Kemkemer, S. Schrank, W. Vogel, H. Gruler, D. Kaufmann, Proc. Natl. Acad. Sci. U.S.A.99, 13783 (2002). · DOI
  13. 10.1016/S1535-6108(03)00047-3 · DOI
  14. 10.1016/S0092-8674(94)90562-2 · DOI · Paper page
  15. S. Serizawa, K. Miyamichi, H. Sakano, Trends Genet.20, 648 (2004). · DOI · Paper page
  16. 10.1093/genetics/149.4.1633 · DOI · Paper page
  17. 10.1073/pnas.1332628100 · DOI · Paper page
  18. 10.1073/pnas.040411297 · DOI · Paper page
  19. S. Hooshangi, S. Thiberge, R. Weiss, Proc. Natl. Acad. Sci. U.S.A.102, 3581 (2005). · DOI · Paper page
  20. 10.1016/S0022-5193(05)80421-7 · DOI
  21. 10.1371/journal.pbio.0020137 · DOI · Paper page
  22. 10.1038/nature02424 · DOI · Paper page
  23. 10.1038/35014651 · DOI · Paper page
  24. H. H. Ng, F. Robert, R. A. Young, K. Struhl, Mol. Cell11, 709 (2003). · DOI · Paper page
  25. 10.1038/35002125 · DOI · Paper page
  26. 10.1038/nature02533 · DOI
  27. 10.1126/science.1102540 · DOI · Paper page
  28. 10.1038/nature749 · DOI · Paper page
  29. C. H. Waddington, Nature183, 1654 (1959). · DOI · Paper page
  30. M. Pigliucci, C. J. Murren, Evolution Int. J. Org. Evolution57, 1455 (2003).
  31. A. K. Jain et al., Pattern Recognition35, 2653 (2002). · DOI · Paper page
  32. T. Shin et al., Nature415, 859 (2002). · doi:10.1038/nature723

Cited by

See all 1,750

Metadata

Authors
Raser, J. M., & O'Shea, E. K.
Venue
Science
Published
2005-09-23
Volume
309
Issue
5743
Pages
2010-2013
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2044692345
Cited by
1,750
References
5
FWCI
29.39
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Noise in Gene Expression: Origins, Consequences, and Control. https://app.cochat.ai/papers/10.1126/science.1105891
The paper
Raser, J. M., & O'Shea, E. K. (2005). Noise in Gene Expression: Origins, Consequences, and Control. Science. https://doi.org/10.1126/science.1105891

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.