CoChat
Sign Up
Cited by 311Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

The Role of NMDA Receptors in Information Processing

Daw, N W, Stein, P S G, Fox, K·1993·Annual Review of Neuroscience
DOI 10.1146/annurev.ne.16.030193.001231
Open this paper in CoChat — free account

Abstract

In this review, we have concentrated on the parallels between the cellular properties of the NMDA receptor and a variety of functional properties within sensory and motor systems. Of course, the NMDA channel exists within the cell in conjunction with a variety of other channels, including non-NMDA channels. Although the NMDA receptor is unique in a cellular sense--it is the only ligand-gated channel that is also voltage dependent and calcium permeable--it is not unique in a functional sense. A cell that has non-NMDA receptors and voltage-sensitive channels will also exhibit nonlinear behavior. Moreover, Buhrle & Sonnhof (1983) demonstrated some time ago that calcium flows into frog motor neurons through more than one type of calcium channel. The contribution to the inflow of calcium from NMDA channels may vary from cell to cell and could easily be a minor proportion of the total. Many authors have pointed out that the NMDA channel has a low conductance at a resting potential of -70 mV. However, many cells in the nervous system are depolarized from -70 mV by excitatory input. Thus, as pointed out above. NMDA receptors make a contribution to the tonic or spontaneous activity of cells in both visual cortex and spinal cord. In practice, many cells are probably working in a range of membrane potentials where the NMDA channels are always open to some extent. Even in the hippocampal slice where a substantial amount of afferent input is removed, NMDA receptors contribute to spontaneous activity (Sah et al 1989). Does the NMDA receptor act as a switch? Does it act as an AND gate? The suggestion that it may act as a switch comes from work on LTP in the hippocampus, which is readily produced by high-frequency stimulation and is abolished by APV. However, activation of the NMDA receptor is only the first in a sequence of reactions leading to LTP: In theory, switch-like behavior could also be produced by calcium-buffering systems within dendritic spines, or by enzymatic processes (Lisman 1985; Zador et al 1990). Fox & Daw (1992) have modeled the action of NMDA and non-NMDA receptors that are activated in parallel with each other, and shown that the occurrence of switch-like behavior depends on the relative density of NMDA versus non-NMDA receptors. Switch-like behavior is not seen in the visual cortex, but might be seen in the hippocampus if the relative density of NMDA receptors there was higher than in the visual cortex.(ABSTRACT TRUNCATED AT 400 WORDS)

Overview

Integrity signals

Registry

Crossref · 10.1146/annurev.ne.16.030193.001231

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 64 references

Cited by

Sorted by citations

Items 201–300 of 311

Related

See all

Metadata

Authors
Daw, N. W., Stein, P. S. G., & Fox, K.
Affiliations
Yale University (US)
ORCID
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
1993-03
Volume
16
Issue
1
Pages
207-222
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev.ne.16.030193.001231
OpenAlex
W2179166911
Cited by
311
References
64
Citations by year
2026: 1 · 2025: 2 · 2024: 7 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 11 · 2012: 17
FWCI
8.30
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ns029343-02)
  • National Eye Institute (R01EY000053, EY-00053)
  • National Institute of Neurological Disorders and Stroke (NS27759, NS29343)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
NMDA receptor, synaptic plasticity, long-term potentiation, switch-like behavior, non-NMDA receptors, calcium influx, spontaneous neuronal activity, hippocampus, visual cortex, motor neurons, dendritic spines, calcium buffering, APV, glutamate receptors, dendritic integration
MeSH terms
Animals, Brain, Mental Processes, Neurons, Nociceptors, Spinal Cord, Synapses, Visual Cortex, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review