The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Role and Regulation of Adenosine in the Central Nervous System
Abstract
▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally present in the extracellular space in brain tissue leads to inhibitory effects that appear to be mediated by both adenosine A 1 and A 2A receptors. Relief from this tonic inhibition by receptor antagonists such as caffeine accounts for the excitatory actions of these agents. Characterization of the effects of adenosine receptor agonists and antagonists has led to numerous hypotheses concerning the role of this nucleoside. Previous work has established a role for adenosine in a diverse array of neural phenomena, which include regulation of sleep and the level of arousal, neuroprotection, regulation of seizure susceptibility, locomotor effects, analgesia, mediation of the effects of ethanol, and chronic drug use.
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Cites
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 1×
“The pharmacological actions of caffeine, which is the most widely used psychoactive drug in the world, are largely attributable to its activity as an adenosine receptor antagonist ( Fredholm et al 1999 ).”
BackgroundA 2A -Adenosine Receptor Reserve for Coronary Vasodilation
Shryock, J. C., Snowdy, S., Baraldi, P. G., Cacciari, B., Spalluto, G., Monopoli, A., Ongini, E., Baker, S. P., & Belardinelli, L. (1998) · Circulation · doi:10.1161/01.cir.98.7.711 · Cited by 199
Recent advances in the molecular biology of nucleoside transporters of mammalian cells
Cass, C. E., Young, J. D., & Baldwin, S. A. (1998) · Biochemistry and Cell Biology · doi:10.1139/o98-095 · Cited by 185
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Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Astrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
Negative feedback control of neuronal activity by microglia
Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. T., Graves, S. M., Uweru, J. O., et al. (2020) · Nature · doi:10.1038/s41586-020-2777-8 · Cited by 979
Metadata
- Authors
- Dunwiddie, T. V., & Masino, S. A.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2001-03
- Volume
- 24
- Issue
- 1
- Pages
- 31-55
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2145758516
- Cited by
- 1,632
- References
- 3
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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