The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Carnitine Metabolism and Function in Humans
Abstract
It is apparent from the foregoing discussion that carnitine plays an essential role in human intermediary metabolism. The question of a dietary requirement for carnitine, particularly for the human infant, is of significant theoretical and practical interest. Aberrant carnitine metabolism resulting from abnormal genetic or acquired conditions may have serious consequences for the affected individual. At present many of the treatment modalities for carnitine deficiency are empirical. Further clarification of the mechanisms by which carnitine depletion is manifest in these conditions is essential for designing treatment programs. Moreover, therapeutic use of carnitine in several human diseases not involving carnitine deficiency per se has been indicated. Before such treatment becomes generally accepted, we must determine precisely the role of this amino acid in the biochemical and physiological events that participate in the pathogenesis of each disease.
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Citations
Cites
Carnitine Deficiency of Human Skeletal Muscle with Associated Lipid Storage Myopathy: A New Syndrome
Engel, A. G., & Angelini, C. (1973) · Science · doi:10.1126/science.179.4076.899 · Cited by 512
Metabolism of the heart in health and disease. Part I
Opie, L. H. (1968) · American Heart Journal · doi:10.1016/0002-8703(68)90168-3 · Cited by 418
Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia
Shug, A. L., Thomsen, J. H., Folts, J. D., Bittar, N., Klein, M. I., Koke, J. R., & Huth, P. J. (1978) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(78)90003-6 · Cited by 247
Tissue distribution of carnitine biosynthetic enzymes in man
Rebouche, C. J., & Engel, A. G. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90133-6 · Cited by 232
Self-citationCARNITINE DEFICIENCY INDUCED DURING INTERMITTENT HÆMODIALYSIS FOR RENAL FAILURE
Bohmer, T., Bergrem, H., & Eiklid, K. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90422-1 · Cited by 227
Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency: An Inherited Cause of Nonketotic Hypoglycemia
Hale, D. E., Batshaw, M. L., Coates, P. M., Frerman, F. E., Goodman, S. I., Singh, I., & Stanley, C. A. (1985) · Pediatric Research · doi:10.1203/00006450-198507000-00006 · Cited by 202
Stanley, C. A., Hale, D. E., Coates, P. M., Hall, C. L., Corkey, B. E., Yang, W., Kelley, R. I., Gonzales, E. L., Williamson, J. R., & Baker, L. (1983) · Pediatric Research · doi:10.1203/00006450-198311000-00008 · Cited by 192
Carnitine levels in human serum in health and disease
Böhmer, T., Rydning, A., & Solberg, H. E. (1974) · Clinica Chimica Acta · doi:10.1016/0009-8981(74)90177-6 · Cited by 188
Adams, R. J., Cohen, D. W., Gupte, S., Johnson, J. D., Wallick, E. T., Wang, T., & Schwartz, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86329-9 · Cited by 169
Carnitine Metabolism and Deficiency Syndromes
Rebouche, C. J., & Engel, A. G. (1983) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)18819-8 · Cited by 157
Self-citation
Cited by
Structure and function of claudins
Krause, G., Winkler, L., Mueller, S. L., Haseloff, R. F., Piontek, J., & Blasig, I. E. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.10.018 · Cited by 829
Carnitine and Acylcarnitines: Pharmacokinetic, Pharmacological and Clinical Aspects
Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.1007/bf03261931 · Cited by 493
Treatment of carnitine deficiency
Winter, S. C. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1024433100257 · Cited by 60
Is sudden death with vitamin C deficiency caused by lack of carnitine?
Okamoto, M., & Ueno, Y. (2006) · Journal of Clinical Forensic Medicine · doi:10.1016/j.jcfm.2005.05.004 · Cited by 4
Metadata
- Authors
- Rebouche, C. J., & Paulson, D. J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1986-07
- Volume
- 6
- Issue
- 1
- Pages
- 41-66
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2108809704
- Cited by
- 255
- References
- 32
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Carnitine Metabolism and Function in Humans. https://app.cochat.ai/papers/10.1146/annurev.nu.06.070186.000353
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- Rebouche, C. J., & Paulson, D. J. (1986). Carnitine Metabolism and Function in Humans. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nu.06.070186.000353
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
