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Cited by 223

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Role of Sunlight in the Cutaneous Production of Vitamin D3

Webb, A R, Holick, M F·1988·Annual Review of Nutrition
DOI 10.1146/annurev.nu.08.070188.002111
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Abstract

INTRODUCTION .. .... . . . . . ...... . . . .... . . . . . . ..... . . . . . . ........ . . . . . 375 HISTORICAL REVIEW........ . . . . . . .... . . . . . . . ....... . . .... . . . . . . . . ... . . . ......... . . . . . . 376 PHOTOCHEMISTRY OF PROVITAMIN D AND ITS PHOTOISOMERS ..... . ........ 377 FORMA nON OF VITAMIN D3 IN SKIN. . . .... . . . . . . . . . ..... . ....... . . . . . . . . . . . . .. 378 Photobiology of Vitamin D3 . .. .. . . . . . . ... .... . ........ . ...... . . . . . . . . . . . . 378 Action Spectra for the Formation of Previtamin D3 and Its Photoisomers . . .. . . . . . .. 380 Factors that Regulate the Cutaneous Production of Vitamin D3. . . . . ........ . . . . . . . . . . . 382 Photodegradation of Vitamin D3.... . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....... . . . . . . . . . . ... 387 Artificial Light Sources and Vitamin D . . ....... . . . . . .. . . . . . . . . ..... . . . .. . . . . . . . . . .. . ....... . 387 EPIDEMIOLOGY OF VITAMIN D . . . . . ......... . . . . . . . . . . . . . . . . . ... . . ......... . . . . . . . 388 Vitamin D Deficiency in Children and Adults ...... . . . . . . . . . . . . . . . .. . .... . . . . . . . . . . . . . . . . . . 388 Environmental Factors . . . . . . . .... . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 391 CONCLUSION . . . ....... . . . ........ . . ..... . . . . . . . . . . . . . .. . . . ...... . . . . . 393

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Crossref · 10.1146/annurev.nu.08.070188.002111

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  • Vitamin D3 is metabolized in the liver by CYP2R1 to calcidiol, and calcidiol is converted to calcitriol in the kidney via CYP27B1.

    “This vitamer is then metabolized in the liver by calciol 25‐hydroxylase (CYP2R1 gene) to form the main plasma and storage form of the vitamin—calcidiol [25(OH)D3]. Calcidiol is subsequently converted into the biologically active form of the vitamin, calcitriol [1,25(OH2)D3] in the kidney via the action of calcidiol 1‐hydroxylase (CYP27B1 gene)”

    From The evolution of human skin pigmentation: A changing medley of vitamins, genetic variability, and UV radiation during human expansion (2023) · cites this paper as Webb & Holick, 1988

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Metadata

Authors
Webb, A. R., & Holick, M. F.
Venue
Annual Review of Nutrition
Publisher
Annual Reviews
Published
1988-07
Volume
8
Issue
1
Pages
375-399
ISSN
  • 0199-9885
  • 1545-4312
DOI
10.1146/annurev.nu.08.070188.002111
Cited by
223
References
1
Language
en

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