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Regulation of the Pyruvate Dehydrogenase Multienzyme Complex
Abstract
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
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“The PDHC is allosterically inhibited by NADH, acetyl-CoA, and ATP, making it a potent sensor of TCA cycle activity and thus a critical node of TCA cycle regulation (discussed further) (52).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [52]
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Dey, R., Naik, S., & Patel, M. S. (1996) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(95)00216-2 · Cited by 3
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Curtis, M. K., McGing, J., Stubbs, B. J., Ball, V., Cochlin, L. E., O'Neill, D., Laustsen, C., Cole, M. A., Robbins, P. A., Tyler, D. J., et al. (2025) · NMR in Biomedicine · doi:10.1002/nbm.70020 · Cited by 2
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Le complexe pyruvate déshydrogénase : de l'organisation moléculaire à la pathologie.
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Wollheim, C. B., & Maechler, P. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0204 · Cited by 1
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Wahl, D. R. (2012) · Deep Blue (University of Michigan)
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Smith, C. M. (2002) · Encyclopedia of Molecular Biology · doi:10.1002/047120918x.emb0008
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Montague-Cardoso, K. (2012) · UCL Discovery (University College London)
PDH REGULATION IN SKELETAL MUSCLE
Kiilerich, K. (2010)
Version, E. (2001)
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Harris, S. R. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
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Alpha-Keto Acid Dehydrogenase Complexes and Glycine Cleavage System
Harris, R. A., Jeoung, N. H., Hwang, B., & Joshi, M. (2008) · Oxidative stress and disease · doi:10.1201/9781420045390.sec2
The Role of the Retinoblastoma Protein Family in Skeletal Myogenesis
Ciavarra, G. (2011) · Library and Archives Canada (Government of Canada)
Fatty Acids and Growth Regulation
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Utilization of Oxidizable Substrates in Brain
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Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_7
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Nelson, D. L., & Cox, M. M. (2001) · Springer-Lehrbuch · doi:10.1007/978-3-662-08289-8_16
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The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology
Träger, T. K., Kyrilis, F. L., Kafetzopoulos, G., Tüting, C., & Kastritis, P. L. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-26629-3_9
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Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency
Keshavan, N., Neugebauer, J., Bellusci, M., Bertini, E., Brown, G., Darín, N., DeBrosse, S. D., Drexler, L., Drexler, S., Enns, G. M., et al. (2026) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.70226 · Cited by 1
A 450K arsenite-binding protein of the rabbit liver cytosol.
Bogdan, G. M. (1994) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- Behal, R. H., Buxton, D. B., Robertson, J. G., & Olson, M. S.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1993-07
- Volume
- 13
- Issue
- 1
- Pages
- 497-520
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2173424827
- Cited by
- 132
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 3 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl024654-10)
- National Heart, Lung, and Blood Institute (HL-24654)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- pyruvate dehydrogenase complex, enzyme regulation, intermittent fasting, health benefits of fasting, physiological mechanisms, metabolic regulation
- MeSH terms
- Animals, Catalysis, Homeostasis, Hormones, Humans, Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase Complex Deficiency Disease
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