The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Nutritional and Hormonal Regulation of Thyroid Hormone Deiodinases
Abstract
Selenocysteine has been identified in the active center of types 1 and 3 iodothyronine deiodinases, two important enzymes regulating the formation and degradation of the active thyroid hormone, 3,5,3′-triiodothyronine (T3). Selenium is thus required for such complex processes as normal growth, brain development, and metamorphosis, all of which are thyroid hormone dependent. Structural and functional analyses of the type 1 deiodinase mRNA allowed identification of the selenocysteine insertion sequence (SECIS) element, a stem-loop structure in the 3′ untranslated region of the mRNA. SECIS elements with conserved sequence and structural features are also present in the 3′ untranslated regions of the mRNAs encoding selenoprotein P and the glutathione peroxidase family of selenoproteins. These elements are necessary and sufficient for directing selenocysteine incorporation into the deiodinases and the other mammalian selenoproteins.
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Citations
Cites
Maternal and Fetal Thyroid Function
Epstein, F. H., Burrow, G. N., Fisher, D. A., & Larsen, P. R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311608 · Cited by 720
Self-citationSILVA, J. E., DICK, T. E., & LARSEN, P. R. (1978) · Endocrinology · doi:10.1210/endo-103-4-1196 · Cited by 189
Self-citationPhenolic and Tyrosyl Ring Deiodination of Iodothyronines in Rat Brain Homogenates
Kaplan, M. M., & Yaskoski, K. A. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109887 · Cited by 179
Houstĕk, J., Vízek, K., Pavelka, S., Kopecký, J., Krejcová, E., Hermanská, J., & Cermáková, M. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.2.8393883 · Cited by 87
van Doom, J., Roelfsema, F., & van der Heide, D. (1982) · Acta Endocrinologica · doi:10.1530/acta.0.1010386 · Cited by 50
Cited by
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Combs, G. F., & Gray, W. P. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00014-x · Cited by 668
Gärtner, R., Gasnier, B. C. H., Dietrich, J. W., Krebs, B., & Angstwurm, M. W. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8421 · Cited by 389
Action of thyroid hormone in brain
Bernal, J. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344003 · Cited by 358
Metadata
- Authors
- Larsen, P. R., & Berry, M. J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1995-07
- Volume
- 15
- Issue
- 1
- Pages
- 323-352
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2142125747
- Cited by
- 175
- References
- 5
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Nutritional and Hormonal Regulation of Thyroid Hormone Deiodinases. https://app.cochat.ai/papers/10.1146/annurev.nu.15.070195.001543
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- Larsen, P. R., & Berry, M. J. (1995). Nutritional and Hormonal Regulation of Thyroid Hormone Deiodinases. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nu.15.070195.001543
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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